Ganoderic acid A from <i>Ganoderma lucidum</i> ameliorates lipid metabolism and alters gut microbiota composition in hyperlipidemic mice fed a high-fat diet

Guo, Weiling; Guo, Jianbin; Liu, Binyu; Lu, Jin-Qiang; Chen, Min; Bai, Weidong; Rao, Pingfan; Ni, Li; Lv, Xu-Cong

doi:10.1039/d0fo00436g

Cited by 69 publications

(47 citation statements)

References 75 publications

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“…and Bifidobacterium spp., produce metabolites such as short-chain fatty acids, bacteriocins, and antimicrobial peptides, which can reduce inflammation, protect against pathogenic microbial infections, increase the integrity of the intestinal epithelium, and modulate immunity to promote host health [ 3 , 4 , 5 , 6 ]. The development of next-generation sequencing technology has led to a more comprehensive and in-depth understanding of the role of gut bacteria in human health and disease [ 7 ]. Compared with traditional probiotics, newly identified native intestinal bacteria such as Akkermansia , Bacteroides , Clostridium , and Blautia have rapidly attracted more attention for their health-promoting and therapeutic utility [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Assessment of the Safety of Blautia producta DSM 2950

et al. 2021

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In recent years, Blautia has attracted attention for its role in ameliorating host diseases. In particular, Blautia producta DSM 2950 has been considered a potential probiotic due to its ability to mitigate inflammation in poly(I:C) induced HT-29 cells. Thus, to promote the development of indigenous intestinal microorganisms with potential probiotic function, we conducted a comprehensive experimental analysis of DSM 2950 to determine its safety. This comprised a study of its potential virulence genes, antibiotic resistance genes, genomic islands, antibiotic resistance, and hemolytic activity and a 14-day test of its acute oral toxicity in mice. The results indicated no toxin-related virulence genes in the DSM 2950 genome. Most of the genomic islands in DSM 2950 were related to metabolism, rather than virulence expression. DSM 2950 was sensitive to most of the tested antibiotics but was tolerant of treatment with kanamycin, neomycin, clindamycin, or ciprofloxacin, probably because it possessed the corresponding antibiotic resistance genes. Oral acute toxicity tests indicated that the consumption of DSM 2950 does not cause toxic side effects in mice. Overall, the safety profile of DSM 2950 confirmed that it could be a candidate probiotic for use in food and pharmaceutical preparations.

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Section: Introductionmentioning

confidence: 99%

A Comprehensive Assessment of the Safety of Blautia producta DSM 2950

et al. 2021

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“…GEP used in this study contains myriads of ganoderic acids and glucans (Table 1). Ganoderic acid A has been demonstrated to reduce obesity via SREBP which is a downstream effector of AMPK [51]. Beta 1,3/1,6 glucan serves as immunomodulator in high-cholesterol induced inflammation [52].…”

Section: Discussionmentioning

confidence: 99%

Ganoderma lucidum Extract Reduces Insulin Resistance by Enhancing AMPK Activation in High-Fat Diet-Induced Obese Mice

et al. 2020

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Ganoderma lucidum is used widely in oriental medicine to treat obesity and metabolic diseases. Bioactive substances extracted from G. lucidum have been shown to ameliorate dyslipidemia, insulin resistance, and type 2 diabetes in mice via multiple 5′ AMP-activated protein kinase (AMPK)-mediated mechanisms; however, further studies are required to elucidate the anti-obesity effects of G. lucidum in vivo. In this study, we demonstrated that 3% G. lucidum extract powder (GEP) can be used to prevent obesity and insulin resistance in a mouse model. C57BL/6 mice were provided with a normal diet (ND) or a high-fat diet (HFD) supplemented with 1, 3, or 5% GEP for 12 weeks and the effect of GEP on body weight, liver, adipose tissue, adipokines, insulin and glucose tolerance (ITT and GTT), glucose uptake, glucose-metabolism related proteins, and lipogenesis related genes was examined. GEP administration was found to reduce weight gain in the liver and fat tissues of the mice. In addition, serum parameters were significantly lower in the 3% and 5% GEP mice groups than in those fed a HFD alone, whereas adiponectin levels were significantly higher. We also observed that GEP improved glucose metabolism, reduced lipid accumulation in the liver, and reduced adipocyte size. These effects may have been mediated by enhanced AMPK activation, which attenuated the transcription and translation of lipogenic genes such as fatty acid synthase (FAS), stearoyl-CoA desaturase 1 (SCD1), and sterol regulatory element-binding protein-1c (SREBP1c). Moreover, AMP-activated protein kinase (AMPK) activation increased acetyl-CoA carboxylase (ACC), insulin receptor (IR), IR substrate 1 (IRS1), and Akt protein expression and activation, as well as glucose transporter type 1/4 (GLUT1/4) protein production, thereby improving insulin sensitivity and glucose metabolism. Together, these findings demonstrate that G. lucidum may effectively prevent obesity and suppress obesity-induced insulin resistance via AMPK activation.

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“…In addition to polysaccharides and triterpenoids displaying a variety of medicinal properties, mushrooms contain many antimicrobial factors, which include lentinan, ganaderiol-F, ganoderic acid-β, lucidumol, PSP, coprinol, campestrin, sparassol, armillaric acid, cortinellin, and ustilagic acid [139][140][141]. These active compounds fight viruses in two major ways: (a) they boost the immune system: directly (specific response) and/or through various factors of humoral and cellular immunity [142]; and (b) they attack the virus directly, which prevents the proliferation of viruses and can stop viral infections from developing [143].…”

Section: Hiv/aidsmentioning

confidence: 99%

Mushroom Nutrition as Preventative Healthcare in Sub-Saharan Africa

et al. 2021

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The defining characteristics of the traditional Sub-Saharan Africa (SSA) cuisine have been the richness in indigenous foods and ingredients, herbs and spices, fermented foods and beverages, and healthy and whole ingredients used. It is crucial to safeguard the recognized benefits of mainstream traditional foods and ingredients, which gradually eroded in the last decades. Notwithstanding poverty, chronic hunger, malnutrition, and undernourishment in the region, traditional eating habits have been related to positive health outcomes and sustainability. The research prevailed dealing with food availability and access rather than the health, nutrition, and diet quality dimensions of food security based on what people consume per country and on the missing data related to nutrient composition of indigenous foods. As countries become more economically developed, they shift to “modern” occidental foods rich in saturated fats, salt, sugar, fizzy beverages, and sweeteners. As a result, there are increased incidences of previously unreported ailments due to an unbalanced diet. Protein-rich foods in dietary guidelines enhance only those of animal or plant sources, while rich protein sources such as mushrooms have been absent in these charts, even in developed countries. This article considers the valorization of traditional African foodstuffs and ingredients, enhancing the importance of establishing food-based dietary guidelines per country. The crux of this review highlights the potential of mushrooms, namely some underutilized in the SSA, which is the continent’s little exploited gold mine as one of the greatest untapped resources for feeding and providing income for Africa’s growing population, which could play a role in shielding Sub-Saharan Africans against the side effects of an unhealthy stylish diet.

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Ganoderic acid A from Ganoderma lucidum ameliorates lipid metabolism and alters gut microbiota composition in hyperlipidemic mice fed a high-fat diet

Abstract: Ganoderic acid A from Ganoderma lucidum has the potential to prevent hyperlipidemia, modulates the composition of gut microbiota in hyperlipidemic mice, and significantly attenuates the liver metabolite profile in hyperlipidemic mice.

Cited by 69 publications

References 75 publications

A Comprehensive Assessment of the Safety of Blautia producta DSM 2950

A Comprehensive Assessment of the Safety of Blautia producta DSM 2950

Ganoderma lucidum Extract Reduces Insulin Resistance by Enhancing AMPK Activation in High-Fat Diet-Induced Obese Mice

Mushroom Nutrition as Preventative Healthcare in Sub-Saharan Africa

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