Ganoderma immunomodulatory proteins: mushrooming functional FIPs

Lin, Jingwei; Chen, Huan; Bai, Yudong; Li, Shoukun; Liang, Gengyuan; Fan, Tianning; Gao, Ningyuan; Wu, Xiupeng; Li, Hui; Chen, Gang; Gao, Yanni; Fan, Jie

doi:10.1007/s00253-022-11839-9

Cited by 8 publications

(2 citation statements)

References 82 publications

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“…The bioactivities of FIPs either derived from edible or medicinal mushrooms, their roles have been qualitatively determined to inhibit cancer (Li et al 2017 ; Lin et al 2021 ; Li et al 2022 ), hemagglutinate blood cells, and selectively enhance the expression of mRNA of cytokines (TNF-a, IL-1, IL-6, and IL-12) in spleen cells and in human peripheral blood lymphocytes [other roles have been reviewed by Lin et al ( 2022 )]. Therefore, FIPs are good candidates for developing novel drugs or new types of functional food supplements for treating and preventing different kinds of diseases including cancer, etc.…”

Section: Motif Analysismentioning

confidence: 99%

In Silico functional and phylogenetic analyses of fungal immunomodulatory proteins of some edible mushrooms

Ramlal

Samanta²

2022

AMB Expr

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Mushrooms are a well known source of many bioactive and nutritional compounds with immense applicability in both the pharmaceutical and food industries. They are widely used to cure various kinds of ailments in traditional medicines. They have a low amount of fats and cholesterol and possess a high number of proteins. Immunomodulators have the ability which can improve immunity and act as defensive agents against pathogens. One such class of immunomodulators is fungal immunomodulatory proteins (FIPs). FIPs have potential roles in the treatment of cancer, and immunostimulatory effects and show anti-tumor activities. In the current study, 19 FIPs from edible mushrooms have been used for comparison and analysis of the conserved motifs. Phylogenetic analysis was also carried out using the FIPs. The conserved motif analysis revealed that some of the motifs strongly supported their identity as FIPs while some are novel. The fungal immunomodulatory proteins are important and have many properties which can be used for treating ailments and diseases and this preliminary study can be used for the identification and functional characterization of the proposed novel motifs and in unraveling the potential roles of FIPs for developing newer drugs.

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Section: Motif Analysismentioning

confidence: 99%

In Silico functional and phylogenetic analyses of fungal immunomodulatory proteins of some edible mushrooms

Ramlal

Samanta²

2022

AMB Expr

View full text Add to dashboard Cite

show abstract

“…All proteins in the FIP family have a molecular weight of approximately 13 kDa with 110–114 amino acids and have an immunoglobulin-like tertiary structure [14] . GMI belongs to the FIP protein family and GMI shares high sequence, structural and functional similarities to other proteins in the FIP group [15] , [16] .…”

Section: Introductionmentioning

confidence: 99%