Ganoderma lucidum ethanol extract abrogates metabolic syndrome in rats: In vivo evaluation of hypoglycemic, hypolipidemic, hypotensive and antioxidant properties

Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake

“…It has been previously revealed that oral administration of GLE ameliorated hyperlipidemia in rats fed with a high-fat diet by regulating the mRNA expression of key genes related to lipid and cholesterol metabolism ( Guo et al, 2018 ; Zhu et al, 2018 ). Moreover, it was also reported that GLE protected against oxidative stress and liver pathological process, and thus may be useful in the management of metabolic syndrome and its complications ( Li et al, 2021 ; Chang et al, 2015 ; Guo et al, 2018 ; Adeyi et al, 2021 ). It is well known that GLE possesses excellent hypolipidemic and hepatoprotective effects, providing a potential viable regimen in the prevention or alleviation of alcoholic liver injury.…”

Antioxidant, antibacterial, antitumor, antifungal, antiviral, anti-inflammatory, and nevro-protective activity of Ganoderma lucidum: An overview

“…From this point of view, GLP can be considered as a new agent for the treatment of hyperlipidemia . Adeyi et al (2021) also reported incredible biological effects, characterized by the in vitro and in vivo antioxidant activities of GLP extracts.…”

Health-Promoting of Polysaccharides Extracted from Ganoderma lucidum

“…GLPs induce the synthesis of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione S-transferase (GST), mitochondrial succinate dehydrogenase (SDH) and reduce glutathione, which protects the endothelium of blood vessels [ 17 ]. They however reduce the activity of nitric oxide synthase (NOS), cytochrome P450, xanthine oxidase and myeloperoxidase, which significantly affect the dysfunction of the vascular endothelium and induce atherosclerosis [ 18 , 50 ]. Undoubtedly, oxidative stress plays a significant role in the etiology of many metabolic diseases that disrupt the proper functioning of many organs.…”

“…Undoubtedly, oxidative stress plays a significant role in the etiology of many metabolic diseases that disrupt the proper functioning of many organs. Prolonged oxidative stress leads to the aging of the body and the occurrence of many age-related diseases [ 50 , 51 ]. In vivo studies have shown that GLP have a beneficial antioxidant effect as a result of a decrease in lipid peroxidation levels and an increase in the activity of antioxidant enzymes [ 19 , 50 ].…”

“…Prolonged oxidative stress leads to the aging of the body and the occurrence of many age-related diseases [ 50 , 51 ]. In vivo studies have shown that GLP have a beneficial antioxidant effect as a result of a decrease in lipid peroxidation levels and an increase in the activity of antioxidant enzymes [ 19 , 50 ]. Depending on the GLP dose used, the above antioxidant properties were checked in mice exposed to ɣ irradiation and cervical carcinoma in rats [ 52 , 53 ].…”