Ganoderma lucidum Modulates Glucose, Lipid Peroxidation and Hepatic Metabolism in Streptozotocin-Induced Diabetic Pregnant Rats

Abstract

The consumption of functional foods, such as mushrooms, apparently influences Gestational Diabetes Mellitus (GDM), and brings benefits to maternal-fetal health. Ganoderma lucidum contains a variety of bioactive compounds, such as polysaccharides, proteins and polyphenols that are able to control blood glucose and be used in anti-cancer therapy. We aimed to evaluate the effects of the consumption of Ganoderma lucidum (Gl) on maternal-fetal outcomes in streptozotocin-induced GDM (GDM-STZ). Pregnant rats were exposed to Gl (100 mg/kg/day) before and after the induction of GDM-STZ (single dose 40 mg/kg) on the eighth pregnancy day. Biochemical and oxidative stress parameters, reproductive performance and morphometry of fetuses were assessed. Gl reduced the glycemic response in the oral glucose tolerance test. Moreover, Gl decreased AST and ALT activities. GDM increased lipid peroxidation, which was reverted by Gl. Catalase and glutathione peroxidase activities were decreased in GDM and the administered Gl after the fetus implantation increased catalase activity. Measurements of the fetal head, thorax, craniocaudal and tail showed greater values in fetuses from rats exposed to Gl compared to GDM. Ganoderma lucidum has an encouraging nutritional and medicinal potential against GDM, since it modifies glucose metabolism, reduces lipid peroxidation, and has protective effects in fetuses born from GDM dams.

Protective effect of Agaricus bisporus mushroom against maternal and fetal damage induced by lead administration during pregnancy in rats

“…Regarding the safety of medicinal mushrooms, Lentinula edodes , which is also an edible mushroom, was evaluated during the gestational period and, like Ab, induced decreases in the morphological measurements of fetuses (Frizo et al, 2014). Our results are still similar to those of Viroel and collaborators (Viroel et al, 2022), who found an increase in some parameters of fetal measurements after using the Ganoderma lucidum mushroom in pregnant rats. Considering the increase in thoracic measurements, all groups exposed to Pb and Ab showed this alteration.…”

Ganoderma lucidumpolysaccharide peptide alleviates hyperuricemia by regulating adenosine deaminase and urate transporters

“…GLPP is a kind of polysaccharide peptide compound isolated from the fruit body of Ganoderma lucidum, which has long been recognized as a precious Chinese herbal medicine with various biological activities, such as antioxidant stress and anti-inflammatory activities. [63][64][65] In addition, GLPP has a protective effect in various metabolic diseases, such as diabetes mellitus and nonalcoholic fatty liver disease, which is dependent on its regulation of AMPK, the core regulation of metabolic homeostasis. 32,66 Interestingly, inhibition of AMPK by UA has been shown in the liver and kidneys.…”

Effects of dietary polyphenols on maternal and fetal outcomes in maternal diabetes

“…Therefore, Gl can potentially act as a nutritional therapeutic agent for diabetic complications, mainly by regulating glucose metabolism and preventing lipid oxidation without adverse reactions. 119…”

“…Therefore, Gl can potentially act as a nutritional therapeutic agent for diabetic complications, mainly by regulating glucose metabolism and preventing lipid oxidation without adverse reactions. 119 Collectively, some polyphenols and Chinese herbal medicines rich in polyphenols exert beneficial effects on insulin and glucose homeostasis in people with GDM. These experiments indicated that polyphenols can alleviate pathological damage to the placenta, liver, pancreas, skeletal muscle, and adipose tissues; reduce inflammation, oxidative stress, and apoptosis; and improve glucose and lipid metabolism and insulin sensitivity, thereby alleviating the symptoms of GDM and improving birth outcomes.…”