Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors

Klupp, Nerida L; Chang, Dennis Hsu-Tung; Hawke, Fiona; Kiat, Hosen; Cao, Huijuan; Grant, Suzanne; Bensoussan, Alan

doi:10.1002/14651858.cd007259.pub2

Cited by 43 publications

(29 citation statements)

References 20 publications

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“…This mushroom is becoming increasingly popular in Western countries as a com plementary medicine for cardiovascular health. 3 In an article published in Nature Communications, Chang et al 2 investigated the antiobesity properties of Ganoderma lucidum in a mouse model of dietinduced obesity. They showed in a very convinc ing manner that daily administration of a WEGL at concentrations from 2-8% to mice fed a highfat diet improved obesity and obesityrelated features such as fat mass, glucose homeostasis and liver and adipose tissue inflammation.…”

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confidence: 99%

Ganoderma lucidum, a new prebiotic agent to treat obesity?

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2015

Nat Rev Gastroenterol Hepatol

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mentioning

confidence: 99%

Ganoderma lucidum, a new prebiotic agent to treat obesity?

Delzenne

Bindels

2015

Nat Rev Gastroenterol Hepatol

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“…Change in immune function correlated with improved microbiota richness, decreased Firmicutes -to- Bacteroidetes ratio and reduced relative abundance of Proteobacteria (cecal content). However, a 2015 Cochrane review of randomized controlled clinical trials (5 trials, N=398) investigating effectiveness of WEGL (as anti-obesity) and G. lucidum for treatment of pharmacologically modifiable risk factors of cardiovascular disease (CVD), did not support use in CVD or type 2 diabetes [121]. In addition, participants who took G. lucidum for four months were 1.67 times (RR=1.67; 95%CI 0.86 to 3.24) more likely to experience an adverse event vs placebo.…”

Section: Nutraceuticalsmentioning

confidence: 99%

Complementary and Alternative Medicine Strategies for Therapeutic Gut Microbiota Modulation in Inflammatory Bowel Disease and their Next-Generation Approaches

Basson

Lam

Cominelli

2017

Gastroenterology Clinics of North America

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SUMMARY The human gastrointestinal tract is resident to a vastly diverse microbial consortium that co-exists through strict rules of invasion, dominance, resilience and succession. While some members possess stronger capabilities for survival than others, each one retains a genome characteristic of their bacterial denomination which subsequently determines survival and ultimately the composition of a human gut microbiome. Collective evidence advocates the concept of gut microbiota modulation via dietary compounds, with or without nutraceutical supplementation. However, consistent reports of strong individuality in responsiveness suggest that initial composition of host microbiota mediates the effect of nutrition modulation. There is also a strong potential for the interaction between mind and microbe to influence responsiveness, although mechanistic understanding of these complex exchanges remains in its infancy at best. Synthetic stool for FMT is a next-generation microbiome-therapy shown effective in treating C.difficile [417] which could provide a feasible alternative to current methods for patients with IBD. Nevertheless, studies investigating optimum timing for FMT administration are essential. Animal and human studies are only starting to highlight the Pandora of interactions that endure between members of gut microbiome, their associated metabolites, dietary compounds, as well as host neurological and immune systems, all of which characteristic to each individual. Advanced research technologies have excelled the scientific evidence in support of CAM and toward generating NG-CAM systems designed for treatment of specific disease states, such as IBD. While the majority of envisioned NG-CAM strategies presently exist in their experimental and discovery phases, many show promise for future clinical application.

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“…In modern Western medicine, Lingzhi is used to provide health benefits such as providing anticancer and antioxidant effects, supporting blood glucose regulation, and modulating the immune system 6 – 8 . However, most studies investigating Lingzhi are animal studies, in vitro studies, or ex vivo studies, with limited human studies to provide significant conclusion to support findings 9 …”

Section: Lingzhimentioning

confidence: 99%