2008
DOI: 10.1529/biophysj.108.140863
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Gap Junction Coupling and Calcium Waves in the Pancreatic Islet

Abstract: The pancreatic islet is a highly coupled, multicellular system that exhibits complex spatiotemporal electrical activity in response to elevated glucose levels. The emergent properties of islets, which differ from those arising in isolated islet cells, are believed to arise in part by gap junctional coupling, but the mechanisms through which this coupling occurs are poorly understood. To uncover these mechanisms, we have used both high-speed imaging and theoretical modeling of the electrical activity in pancrea… Show more

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Cited by 224 publications
(383 citation statements)
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“…This follows the well established role gap junctions play in synchronizing the oscillatory regulation of [Ca 2ϩ ] i (18,20). In mouse islets, the decrease in average gap junction coupling (average recovery rate) was substantially greater than the decrease in the number of cells showing measurable gap junction coupling (% of cells showing recovery).…”
Section: Low Levels Of Pro-inflammatory Cytokines Disrupt [Ca 2ϩ ] Isupporting
confidence: 76%
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“…This follows the well established role gap junctions play in synchronizing the oscillatory regulation of [Ca 2ϩ ] i (18,20). In mouse islets, the decrease in average gap junction coupling (average recovery rate) was substantially greater than the decrease in the number of cells showing measurable gap junction coupling (% of cells showing recovery).…”
Section: Low Levels Of Pro-inflammatory Cytokines Disrupt [Ca 2ϩ ] Isupporting
confidence: 76%
“…Connexin36 (Cx36) gap junctions strongly regulate [Ca 2ϩ ] i dynamics within the islet (18) by coordinating glucose-induced membrane depolarization. Under stimulatory conditions, gap junction coupling coordinates [Ca 2ϩ ] i oscillations across the islet, first phase insulin release, and second phase insulin pulses (19).…”
mentioning
confidence: 99%
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“…This is consistent with previous studies showing a critical role of the cation in the activation of ER stress, the generation of ROS, the control of mitochondrial function 40 and the activation of AMPK. 41 Cx36 overexpression increases the basal Ca 2 þ stores of ER and prevents their depletion after exposure to cytokines (present data), whereas loss of Cx36 impairs the intercellular synchronization of Ca 2 þ transients, [42][43][44][45] whose generation requires proper ER Ca 2 þ stores. 46 The homeostasis of ER Ca 2 þ is controlled by many factors, including inositol 1,4,5-trisphosphate (IP3), which can permeate gap junctions and contribute to mitochondrial apoptosis.…”
Section: Discussionsupporting
confidence: 56%
“…This separation is possible in juvenile MLIs, which have a well-characterized cellular biophysical compartmentalization with time constants below ∼5 ms (18). The present method may likewise be of use in estimating the electrical connectivity of coupled networks formed by relatively compact cells with a small number of neighbors like pancreatic β-cells (35). It remains to be seen whether a similar separation can be obtained in other interneuron networks.…”
Section: (Yellow Cellsmentioning
confidence: 66%