Gaps in using bronchodilators, inhaled corticosteroids and influenza vaccine among 23 high- and low-income sites

Gnatiuc, Louisa; Buist, A. Sonia; Kato, Bernet; Janson, Christer; Aït-Khaled, N; Nielsen, Rune; Koul, Parvaiz A; Niżankowska‐Mogilnicka, Ewa; Obaseki, Daniel O.; Idolor, Luisito F.; Harrabi, Imed; Burney, Peter

doi:10.5588/ijtld.14.0263

Cited by 24 publications

(16 citation statements)

References 20 publications

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“…This trend of poor vaccination uptake is consistent with our previous report of poor uptake of influenza and pneumococcal vaccination in patients with COPD from low-income countries as compared to those from high-income countries. [20]…”

Section: Discussionmentioning

confidence: 99%

Respiratory viruses in acute exacerbations of chronic obstructive pulmonary disease

et al. 2017

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Objective:Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) cause significant morbidity, mortality, and an inexorable decline of lung function. Data from developed countries have shown viruses to be important causes of AECOPD, but data from developing countries like India are scant. We set out to determine the contribution of viruses in the causation of hospitalized patients with AECOPD.Methods:Twin nasopharyngeal/oropharyngeal swabs collected from 233 patients admitted with an acute AECOPD and tested for respiratory viruses including respiratory syncytial virus A and B, parainfluenza were (PIV) 1, 2, 3, and 4, human metapneumovirus (hMPV) A and B, influenza A and B, enterovirus, corona NL65, OC43, and 229E viruses, adenovirus 2 and 4, rhinovirus, and bocavirus, by duplex real time reverse-transcription polymerase chain reaction (qRT-PCR) using CDC approved primers and probes. Samples positive for influenza A were subtyped for A/H1N1pdm09 and A/H3N2 whereas influenza B samples were subtyped into B/Yamagata and B/Victoria subtypes, using primers and probes recommended by CDC, USA.Results:Respiratory viruses were detected in 46 (19.7%) cases, influenza A/H3N2 and rhinoviruses being the most common viruses detected. More than one virus was isolated in four cases consisting of hMPV-B + adeno-2 + Inf-B; rhino + H3N2, PIV-1 + rhino; and PIV-1+ hMPV-B in one case each. Ancillary supportive therapeutic measures included bronchodilators, antibiotics, steroids, and ventilation (noninvasive in 42 and invasive in 4). Antiviral therapy was instituted in influenza-positive patients. Three patients with A/H3N2 infection died during hospitalization.Conclusions:We conclude that respiratory viruses are important contributors to AECOPD in India. Our data calls for prompt investigation during an exacerbation for viruses to obviate inappropriate antibiotic use and institute antiviral therapy in viral disease amenable to antiviral therapy. Appropriate preventive strategies like influenza vaccination also need to be employed routinely.

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Section: Discussionmentioning

confidence: 99%

Respiratory viruses in acute exacerbations of chronic obstructive pulmonary disease

et al. 2017

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“…In some cases, this situation occurred because they had not yet received a diagnosis of COPD; it is also possible that access to bronchodilators was limited in some cases by finance. This problem is also recognized globally, 31 and we speculate that Tai Chi may have potential as a low-cost initial therapy in COPD.…”

Section: Significance Of the Findingsmentioning

confidence: 76%

Tai Chi and Pulmonary Rehabilitation Compared for Treatment-Naive Patients With COPD

Polkey

Qiu

Zhou

et al. 2018

Chest

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“…Therefore, better understanding of factors affecting low compliance with vaccination at the individual level is crucial and should be elucidated in future studies [19].…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting Influenza Vaccination Rates among Patients with Chronic Obstructive Pulmonary Disease in Rize, Turkey

et al. 2018

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OBJECTIVES: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are major components of COPD-related socioeconomic burden. Upper or lower respiratory tract infections, usually caused by respiratory viruses or bacteria, are common causes of AECOPD. Vaccination aganist influenza virus and Streptoccus pneumoniae, the most prevalent agents, is recommended by COPD guidelines. The aims of this study were to determine the factors affecting vaccination among patients with COPD and to assess the effect of vaccination status on AECOPD. MATERIALS AND METHODS:Patients with COPD were recruited from the outpatient clinic of a tertiary hospital between December 2014 and January 2015. Demographic data, vaccination status, and COPD-related hospital admissions triggered by tracheobronchial infections were evaluated. RESULTS:In total, 108 patients were enrolled; 102 (94%) subjects were male, and 6 (6%) subjects were female; the mean age was 65.6 years. The number of patients who had received pneumococcal and influenza vaccinations were 8 (0.07%) and 36 (33.3%), respectively. There was no significant correlation between the level of education and vaccination status. No significant difference was found between two groups in terms of exacerbation frequency, hospitalization rates, mMRC scores, and COPD stages. CONCLUSION:More efforts by both physicians and patients are needed to reach the ideal rates of vaccination for COPD.

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Gaps in using bronchodilators, inhaled corticosteroids and influenza vaccine among 23 high- and low-income sites

Cited by 24 publications

References 20 publications

Respiratory viruses in acute exacerbations of chronic obstructive pulmonary disease

Respiratory viruses in acute exacerbations of chronic obstructive pulmonary disease

Tai Chi and Pulmonary Rehabilitation Compared for Treatment-Naive Patients With COPD

Factors Affecting Influenza Vaccination Rates among Patients with Chronic Obstructive Pulmonary Disease in Rize, Turkey

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