Garcinia atroviridis – A review on phytochemicals and pharmacological properties

Taher, Muhammad; Hamidon, Hanisuhana; Susanti, Deny; Zakaria, Zainul Amiruddin

doi:10.12991/marupj.259879

Cited by 21 publications

(20 citation statements)

References 20 publications

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“…The availability and stability of phenolic and flavonoid may contribute to this antioxidant activity. Among the GA fruit acids, hydroxycitric acid (HCA), citric acid, tartaric acid, and ascorbic acid contribute to the antioxidant activity of GA (Rittirut and Siripatana, 2006;Hamidon et al, 2017). HCA was detected as one of the main compounds in MeGa.…”

Section: Discussionmentioning

confidence: 99%

“…to fat) through the inhibition of ATP-citratelyase production in cells (Chuah et al, 2012;Hamidon et al, 2017). Furthermore, HCA is believed to improve the level of blood cholesterol and dilation of blood vessels, and reduces excessive fat absorption (Yapwattanaphun et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Many herbal products lack scientific evidence on their safety profiles and their respective mechanisms of actions before they are marketed. Despite many studies reporting on the antioxidant and weight reduction properties of the leaves and fruit extracts of GA (Alias et al, 2017;Hamidon et al, 2017;Lumbantobing et al, 2017), no comprehensive study is available on the safety of GA extracts according to standard guidelines such as good laboratory practice and OECD. Therefore, phytochemical composition and safety limits of the methanolic extract of GA (MeGa) fruit were investigated and a metabolomics study was further conducted to study the changes of metabolic pathways in obese rats treated with MeGa.…”

Section: Introductionmentioning

confidence: 99%

“…It is widely distributed in Peninsular Malaysia, Thailand, Myanmar, and India (Mackeen et al, 2000;Hamidon et al, 2017). Almost all parts of the tree such as fruit, leaves, roots, and stem bark can be used either for food seasoning or medicinal purposes, including antioxidant, antiobesity, antiinflammatory, and cytotoxic activities (Pangsuban et al, 2009;Hamidon et al, 2017). GA leaf extract possesses antioxidant properties with protondonating ability serving as a free-radical scavenging agent (Nursakinah et al, 2012).…”

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confidence: 99%

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The methanolic extract of Garcinia atroviridis (MeGa) reduces body weight and food intake, and improves lipid profiles by altering the lipid metabolism: a rat model

Lim¹,

NASIR²,

Teh³

et al. 2020

Turk J Biol

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Garcinia species are widely used for their slimming effects via increased fat burning and suppression of satiety. However, scientific evidence for the biological effects of Garcinia atroviridis (GA) is lacking. We investigated the phytochemical composition, safety profiles, and antioxidant and antiobesity effects of methanolic extracts of Garcinia atroviridis (MeGa) in obese female rats. Repeated dose toxicity studies were conducted according to the OECD guidelines. Upon sacrifice, haematological, biochemical, lipid profile, and serum-based metabolomics analyses were performed to evaluate metabolic expression changes and their related pathways. MeGa contains several phytochemical groups and GA fruit acids. MeGa was found to be nontoxic in both male and female rats with an oral lethal dose (LD50) of 2000 mg/kg. After 9 weeks of treatment, MeGa-treated obese rats had lower weight gain and better lipid profiles (cholesterol and triglyceride), which correlated with the altered metabolic pathways involved in the metabolism of lipid (glycerophospholipid) and biosynthesis of unsaturated fatty acid. In addition, MeGa caused differential metabolism pathways of arachidonic acid and tryptophan that affect the inflammatory response and suppression of appetite. We concluded that MeGa is safe, and its slimming effects are due to the differential metabolism of lipids

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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The methanolic extract of Garcinia atroviridis (MeGa) reduces body weight and food intake, and improves lipid profiles by altering the lipid metabolism: a rat model

Lim¹,

NASIR²,

Teh³

et al. 2020

Turk J Biol

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“…Irrespective of ancient origin, medicinal plants still form the basis of traditional healthcare systems. Phytochemicals are described as chemicals from plant origin which confers health benefits, but are not included in essential nutrients as like carbohydrates, proteins and fats (Taher et al 2017). Chemically, polyphenols are compounds having large number of phenol structural units.…”

Section: Introductionmentioning

confidence: 99%

Anti-oxidative, physico-chemical and sensory attributes of burfi affected by incorporation of different herbs and its comparison with synthetic anti-oxidant (BHA)

et al. 2017

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Six different herbs, viz., turmeric, ginger, clove, curry leaves, basil leaves and small cardamom, were incorporated (@1% of ) into, a heat desiccated-sweetened milk product, for their ability to act as natural anti-oxidant and were compared against butylated hydroxyanisole (BHA). Anti-oxidative potential of significantly increased with herbs incorporation, which was in the order of clove> turmeric > basil leaves > curry leaf > ginger > cardamom. However, it was lower when compared to BHA added samples. Gross compositional attributes of remained unaffected upon herb incorporation, however, significant lowering in water activity was observed upon cardamom and clove addition. Hunter color analysis revealed that cloves decreased lightness and increased redness, turmeric increased yellowness, and basil and curry leaves increased greenness in. Texture attributes viz., hardness, springiness and gumminess were significantly higher for clove and cardamom . Sensory evaluation revealed that among the different herbs, cardamom is highly preferred in followed by ginger, turmeric, clove, curry leaves and basil leaves. However, no significant difference in sensory attributes were observed between control, cardamom and BHA added samples.

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Garcinia

Mini Raj,

Vikram,

Muhammed Nissar

et al. 2023

Handbook of Spices in India: 75 Years of Research and Development

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Garcinia atroviridis – A review on phytochemicals and pharmacological properties

Cited by 21 publications

References 20 publications

The methanolic extract of Garcinia atroviridis (MeGa) reduces body weight and food intake, and improves lipid profiles by altering the lipid metabolism: a rat model

The methanolic extract of Garcinia atroviridis (MeGa) reduces body weight and food intake, and improves lipid profiles by altering the lipid metabolism: a rat model

Anti-oxidative, physico-chemical and sensory attributes of burfi affected by incorporation of different herbs and its comparison with synthetic anti-oxidant (BHA)

Garcinia

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