Garcinia kola aqueous suspension prevents cerebellar neurodegeneration in long-term diabetic rat – a type 1 diabetes mellitus model

Farahna, Mohammed; Etet, Paul Faustin Seke; Osman, Sayed Y; Yurt, Kıymet Kübra; Amir, Naheed; Vecchio, Lorella; Aydin, Işınsu; Aldebasi, Yousef H.; Azimullah, Sheikh; Chijuka, John C.; Kaplan, Süleyman; Adem, Abdu

doi:10.1016/j.jep.2016.11.001

Cited by 13 publications

(18 citation statements)

References 39 publications

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“…Standard procedures were used, as previously described [ 31 ], on randomly selected sections (6 μm-thick) made on paraffin-embedded brain right hemispheres, in the coronal plane. Primary antibodies used were goat anti-NeuN (mature neuron marker, 1:1000 dilution), goat anti-GFAP (astrocyte marker, 1:100 dilution), goat anti-iba1/CD68 (microglial marker, 1:1000 dilution), goat anti-TNF-α (pro-inflammatory cytokine, 1:500 dilution), rabbit anti-Fas (apoptosis mediator, 1:500 dilution), rabbit anti-Fas ligand (death receptor, 1:500 dilution), and rabbit anti-caspase 3 (marker of apoptosis, 1:500 dilution) (Santa Cruz Biotechnology, CA).…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the safety of conventional lighting replacement by artificial daylight

Etet

Farahna

Khayr

et al. 2017

J Microsc Ultrastruct

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Background:Short morning exposure to high illuminance visible electromagnetic radiations termed as artificial daylight is beneficial for the mental health of people living in geographical areas with important seasonal changes in daylight illuminance. However, the commercial success of high illuminance light sources has raised the question of the safety of long hour exposure.Methods:We have investigated the effect of the replacement of natural daylight by artificial daylight in Swiss mice raised under natural lighting conditions. Mice were monitored for neurotoxicity and general health changes. They were submitted to a battery of conventional tests for mood, motor and cognitive functions’ assessment on exposure day (ED) 14 and ED20. Following sacrifice on ED21 due to marked signs of neurotoxicity, the expression of markers of inflammation and apoptosis was assessed in the entorhinal cortex and neurons were estimated in the hippocampal formation.Results:Signs of severe cognitive and motor impairments, mood disorders, and hepatotoxicity were observed in animals exposed to artificial daylight on ED20, unlike on ED14 and unlike groups exposed to natural daylight or conventional lighting. Activated microglia and astrocytes were observed in the entorhinal cortex, as well as dead and dying neurons. Neuronal counts revealed massive neuronal loss in the hippocampal formation.Conclusions:These results suggest that long hour exposure to high illuminance visible electromagnetic radiations induced severe alterations in brain function and general health in mice partly mediated by damages to the neocortex-entorhinal cortex-hippocampus axis. These findings raise caution over long hour use of high illuminance artificial light.

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Section: Methodsmentioning

confidence: 99%

Evaluation of the safety of conventional lighting replacement by artificial daylight

Etet

Farahna

Khayr

et al. 2017

J Microsc Ultrastruct

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“…In a study by Ali et al (2017), streptozotocin-induced diabetic rats showed a significant improvement in hyperglycemia (42 %) and plasma insulin levels, and a decrease in glycated hemoglobin levels when treated with high doses (1000 mg kg -1 ) of G. pedunculata methanolic extract. The aqueous extract of G. kola also administered to diabetic rats promoted an improvement in the glucose levels of these animals in relation to those that received distilled water, as demonstrated by Farahna et al (2017).…”

Section: Garcinia and Glycemic Controlmentioning

confidence: 79%

Garcinia fruit: in the forests and domestic orchards, the prevention of diseases of modernity

Farinazzi-Machado¹,

Silva²

2021

Int. J. Curr. Res. Biosci. Plant Biol.

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The genus Garcinia has many varieties of fruit trees, which are found in rural and urban backyards, tropical forests and domestic orchards of several tropical countries. Fruits have a great diversity of metabolites, among which phenolic compounds stand out for their potential antioxidant, anti-inflammatory and other effects, and which have a preventive action on diseases of modernity. This review aimed to associate studies on the metabolic activities of Garcinia fruits and their numerous effects on health risk factors, such as obesity, hyperglycemia, inflammatory processes and dyslipidemias. Scientific articles published in English, Portuguese and Spanish were selected, which carried out studies involving the administration of Garcinia fruits in vitro and in vivo, mainly in the last five years. Sixty relevant articles were included in the study. Studies have shown that the Garcinia fruit species can be used in body weight control and prevention of cardiovascular disorders, cancer and diabetes mellitus, among other diseases associated with oxidative stress.

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“…In the histopathological studies, increased number of Purkinje cells on left cerebellum (cresyl fast violet staining) and decreased inflammation and neurodegeneration factors on right cerebellum (H&E staining) were observed in treated groups. It has been demonstrated that G. kola can decrease the inflammation by decreasing the expression of TNF‐α and Fas in the brain of treated animals and can improve neuro‐inflammation and neurodegeneration due to diabetes (Farahna et al, 2017).…”

Section: Resultsmentioning

confidence: 99%

“…Medicinal plants and their extracts act by reducing inflammatory factors such as Fas, NFkBP65, TNFα, CD68, lymphocyte and macrophage and by this way could modulate diabetic nervous damages. Some of these herbs are A. paniculata , G. kola , C. sativus , and Grape seed (Etet et al, 2017; Farahna et al, 2017; Radhika et al, 2012; Samarghandian et al, 2014; Xu et al, 2008). Another group of plants does their effect by reducing blood glucose and raising glucose uptake by cells.…”

Section: Discussionmentioning

confidence: 99%

Medicinal plants for diabetes associated neurodegenerative diseases: A systematic review of preclinical studies

Khazaei

Pesce

Patruno

et al. 2020

Phytotherapy Research

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Diabetes mellitus is a metabolic defect with many complications for the patients. Deaths due to diabetes and its complications are increasing, and one of the most serious consequences are the neurological disorders. Chemical treatments have irreversible side effect and therefore the aim of this study is to evaluate the medicinal plants used for treatment of cognitive impairments and neurodegenerative diseases associated with diabetes in 2004–2020 period. Electronic databases used were PubMed, Scopus and Cochrane library. The keywords used were “diabetes,” “plant,” “herb,” “neurodegenerative,” “neurodegeneration,” “cognitive,” “cognition,” “Alzheimer,” “dementia.” The non‐English articles, repetitive articles and review studies were excluded. From total of 3,590 results, 58 articles are included in the study. The results show that many chemical treatments considered for this disease simply control hyperglycemia, but cannot improve the complications of diabetes. Herbal medicine could be more effective due to the high antioxidant activity of some medicinal plants. Biologically active substances of medicinal plants can improve the neurological disorders caused by diabetes via several pathways. The most important pathway is related to antioxidant properties. Other pathways include antiinflammatory, anti‐apoptotic, neurotoxicity inhibition, neuronal death, increasing the uptake of glucose by cells and improve neurotransmitters levels involved in learning and memory.

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Garcinia kola aqueous suspension prevents cerebellar neurodegeneration in long-term diabetic rat – a type 1 diabetes mellitus model

Cited by 13 publications

References 39 publications

Evaluation of the safety of conventional lighting replacement by artificial daylight

Evaluation of the safety of conventional lighting replacement by artificial daylight

Garcinia fruit: in the forests and domestic orchards, the prevention of diseases of modernity

Medicinal plants for diabetes associated neurodegenerative diseases: A systematic review of preclinical studies

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