Garcinia lactone

Mahapatra, Sudarshan; Mallik, Srijita Basu; Rao, G. Venkateswara; Reddy, G. Chandrasekara; Row, T. N. Guru

doi:10.1107/s160053680703838x

Cited by 5 publications

(4 citation statements)

References 1 publication

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“…Figure 1 A shows the LC–UV profile of GC1 kudam puli extract. (-)-HCA, (-)-HCAL, and citric acid were detected in all the samples, as previously reported by other authors [ 14 , 20 , 26 , 27 ]. Despite the low polarity and small size of these acids, an acceptable resolution between them was achieved under the applied chromatographic conditions.…”

Section: Resultssupporting

confidence: 89%

Quality Evaluation of Dietary Supplements for Weight Loss Based on Garcinia cambogia

et al. 2022

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Food supplements of plant origin for weight control are increasingly being demanded by consumers as a way to promote good health. Among them, those based on Garcinia cambogia (GCFS) are widely commercialized considering their bioactive properties, mainly due to (-)-hydroxycitric acid ((-)-HCA). However, recently, controversy has arisen over their safety; thus, further research and continuous monitoring of their composition is required. Hence, in this work, a multi-analytical approach was followed to determine not only (-)-HCA but also other constituents of 18 GCFS, which could be used as quality markers to detect fraudulent practices in these samples. Discrepancies between the declared (-)-HCA content and that experimentally determined were detected by LC–UV in 33% of the samples. Moreover, GC–MS analyses of GCFS allowed the detection of different compounds not present in G. cambogia fruits and not declared on supplement labels, probably related to heat exposure or to the addition of excipients or other extracts. This multi-analytical methodology is shown to be advantageous to address different fraudulent practices affecting the quality of these supplements.

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Section: Resultssupporting

confidence: 89%

Quality Evaluation of Dietary Supplements for Weight Loss Based on Garcinia cambogia

et al. 2022

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“…The absolute configuration found thus agrees with that originally proposed by Boll et al (1969) for hibiscus acid. The structure of garcinia lactone, an epimer of hibiscus acid, has been reported (Mahapatra et al, 2007). The comparable molecular geometries of (I) and its epimer are similar.…”

Section: Structural Commentarymentioning

confidence: 95%

“…A search of the Cambridge Structural Database (Version 5.37, searched June 2017; Groom et al, 2016) yielded few relevant structures. For hibiscus acid, only the structures of a Ca salt form (Glusker et al, 1972) and of the diastereomer mentioned previously (Mahapatra et al, 2007) have been reported. The closest relative of (II) to have been structurally described is a derivative with additional OH and Me substituents on the fivemembered ring (Evans et al, 1997).…”

Section: Database Surveymentioning

confidence: 99%

Crystal structures of hibiscus acid and hibiscus acid dimethyl ester isolated fromHibiscus sabdariffa(Malvaceae)

et al. 2017

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The biologically active title compounds have been isolated from Hibiscus sabdariffa plants, hibiscus acid as a dimethyl sulfoxide monosolvate [systematic name: (2S,3R)-3-hydroxy-5-oxo-2,3,4,5-tetrahydrofuran-2,3-dicarboxylic acid dimethyl sulfoxide monosolvate], C6H6O7C2H6OS, (I), and hibiscus acid dimethyl ester [systematic name: dimethyl (2S,3R)-3-hydroxy-5-oxo-2,3,4,5- tetrahydrofuran-2,3-dicarboxylate], C8H10O7, (II). Compound (I) forms a layered structure with alternating layers of lactone and solvent molecules, that include a two-dimensional hydrogen-bonding construct. Compound (II) has two crystallographically independent and conformationally similar molecules per asymmetric unit and forms a one-dimensional hydrogen-bonding construct. The known absolute configuration for both compounds has been confirmed

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“…We questioned if the observed increase in LSR protein levels was due to the HCA, which is present in GCE as a potassium salt or as a lactone [29]. To test this, mouse Hepa1-6 cells [21] were incubated for 18 h at 37 • C with HCA in either form.…”

Section: Treatment Of Hepa1-6 Cells With Hcamentioning

confidence: 99%

Garcinia cambogia Extract Increased Hepatic Levels of Lipolysis-Stimulated Lipoprotein Receptor and Lipids in Mice on Normal Diet

Hanse,

Akbar,

Layeghkhavidaki

et al. 2023

IJMS

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Garcinia cambogia extract (GCE) is a popular weight-loss supplement that also lowers plasma triglyceride (TG) levels. We hypothesized that GCE-mediated inhibition of ATP citrate lyase and thereby hepatic TG production could lead to compensatory mechanisms, including increased hepatic TG uptake via lipoprotein receptors. GCE (20 mg/day) administered 40 days orally to female C57BL/6Rj mice on a standard chow diet led to a decrease in both plasma fasting and post-prandial TG-rich lipoprotein levels, but with no significant change in body weight gain. Lipolysis stimulated lipoprotein receptor (LSR) protein levels, but not those of LDL-receptor, were increased as compared to controls. Mouse Hepa1-6 cells treated with the GCE active ingredient, hydroxycitrate, also led to increased LSR protein levels. Hepatic total cholesterol, TG, and muscle TG contents were higher in GCE-treated animals as compared to controls, whereas adipose TG levels were unchanged. LSR and LDL-receptor protein levels were correlated with liver total cholesterol, but only LDL-receptor was associated with liver TG. These results show that GCE treatment in mice on a standard chow diet led to significantly increased liver and muscle lipids, with no significant change in adipose tissue TG levels, which should be considered in the long-term use of GCE.

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Garcinia lactone

Cited by 5 publications

References 1 publication

Quality Evaluation of Dietary Supplements for Weight Loss Based on Garcinia cambogia

Quality Evaluation of Dietary Supplements for Weight Loss Based on Garcinia cambogia

Crystal structures of hibiscus acid and hibiscus acid dimethyl ester isolated fromHibiscus sabdariffa(Malvaceae)

Garcinia cambogia Extract Increased Hepatic Levels of Lipolysis-Stimulated Lipoprotein Receptor and Lipids in Mice on Normal Diet

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