Garcinia morella fruit, a promising source of antioxidant and anti-inflammatory agents induces breast cancer cell death via triggering apoptotic pathway

Choudhury, Bhaswati; Kandimalla, Raghuram; Elancheran, R.; Bharali, Rupjyoti; Kotoky, Jibon

doi:10.1016/j.biopha.2018.04.068

Cited by 40 publications

(31 citation statements)

References 51 publications

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“…The authors obtained 500 mg garcinol and 101 mg isogarcinol from 5.2 kg dried G. multiflora fruits (powdered dried G. multiflora fruits were extracted with 95 % ethanol and the ethanol extract was extracted with petroleum ether followed by column chromatography on silica gel and recrystallization to obtain garcinol) . Garcinol was also detected in and isolated from plants of the Garcinia species G. morella , G. yunnanensis , G. xanthochymus and G. travancorica . In addition, garcinol and isogarcinol were recently found in the stem bark of the Garcinia species G. buchananii .…”

Section: An Update On the Isolation Analysis And Synthesis Of Garcimentioning

confidence: 99%

“…Suppression of caspase‐3/iPLA 2 and NF‐ κ B/Twist1 signaling (garcinol), p53 dependent induction of Bax (garcinol), suppression of Bcl‐X L (garcinol), proteasome‐based degradation of ADA3 (garcinol)…”

Section: An Update On the Activities Of Garcinol And Isogarcinol Agaimentioning

confidence: 99%

“…The chloroform extract of G. morella rich in bioactive garcinol exhibited distinct growth inhibitory effects against three breast cancer cell lines (MCF‐7, MDA‐MB‐231, SKBR3). MCF‐7 cells treated with the G. morella chloroform extract revealed increased apoptosis levels by p53 dependent induction of Bax and suppression of Bcl‐X L …”

Section: An Update On the Activities Of Garcinol And Isogarcinol Agaimentioning

confidence: 99%

“…[12] Garcinol was also detected in and isolated from plants of the Garcinia species G. morella, G. yunnanensis, G. xanthochymus and G. travancorica. [13][14][15][16] In addition, garcinol and isogarcinol were recently found in the stem bark of the Garcinia species G. buchananii. [17] Isogarcinol was also isolated from G. punctata and G. ovalifolia.…”

Section: An Update On the Isolation Analysis And Synthesis Of Garcimentioning

confidence: 99%

“…Increased apoptosis and cell growth inhibition (garcinol), [33] inhibition of angiogenesis and invasion (garcinol), [33] inhibition of DNA repair (garcinol) [34] Suppression of mPGES1, HIF-1α, VEGF, MMP (garcinol), [33] inhibition of base excision repair via HAT inhibition (garcinol) [34] -Breast cancer Sensitization to taxol (garcinol), [36] increased apoptosis (garcinol) [13] Suppression of caspase-3/iPLA 2 and NF-κB/Twist1 signaling (garcinol), [36] p53 dependent induction of Bax (garcinol), [13] suppression of Bcl-X L (garcinol), [13] proteasome-based degradation of ADA3 (garcinol) [55] Sensitization to taxol in orthotopic 4T1 mammary carcinoma (garcinol) [36] Prostate cancer…”

Section: Cancer Type Effects Mechanismsmentioning

confidence: 99%

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Chemical and Biological Aspects of Garcinol and Isogarcinol: Recent Developments

Schobert

Biersack

2019

Chemistry & Biodiversity

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The natural polyisoprenylated benzophenone derivatives garcinol and isogarcinol are secondary plant metabolites isolated from various Garcinia species including Garcinia indica. This review takes stock of the recent chemical and biological research into these interesting natural compounds over the last five years. New biological sources and chemical syntheses are discussed followed by new insights into the activity of garcinol and isogarcinol against cancer, pathogenic bacteria, parasite infections and various inflammatory diseases.

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Section: An Update On the Isolation Analysis And Synthesis Of Garcimentioning

confidence: 99%

Section: An Update On the Activities Of Garcinol And Isogarcinol Agaimentioning

confidence: 99%

Section: An Update On the Activities Of Garcinol And Isogarcinol Agaimentioning

confidence: 99%

Section: An Update On the Isolation Analysis And Synthesis Of Garcimentioning

confidence: 99%

Section: Cancer Type Effects Mechanismsmentioning

confidence: 99%

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Chemical and Biological Aspects of Garcinol and Isogarcinol: Recent Developments

Schobert

Biersack

2019

Chemistry & Biodiversity

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Synergetic Combination of Bio‐Electrolytes and Bio‐Fluidic Channels as a Novel Resource of Sustainable Energy

Nath,

Bora,

Gogoi

et al. 2024

Adv Funct Materials

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Exploration for sustainable energy resources is essential to minimize the dependence on fossil fuels and to improve environmental parameters. Here, the possibility of utilizing bio‐waste‐derived electrolytes as an electrical energy resource by placing them across semipermeable membranes prepared through parallel stacking of coir fibers is examined. The nanofluidic membrane (d‐CF‐V) prepared by modifying the inner walls of the bio‐fluidic channels with atomically thin layers of vanadium pentoxide (VO) shows excellent perm‐selectivity (t+ = 0.87, with 1000‐fold concentration difference) and electricity conversion efficiency (≈ 28.2%). With simulated sea and river water, the d‐CF‐V yields output energy up to 2.4 W m−2, similarly with mineral acid bases (0.5 m HCl and 0.01 m NaOH), the d‐CF‐V shows an energy output of 11.8 W m−2. The sun‐dried Garcinia morella (Kuji thekera), and charred peels of Musa balbisiana (banana) are used as sustainable sources of bio‐electrolytes, which in combination with permselective d‐CF‐V yielded a power density of ≈1.4 W m−2. By replacing standard Ag/AgCl electrodes with nanomaterials exhibiting contrasting charge transfer activities, oxidized carbon nanotube membrane (o‐CNT) and polyaniline (PANI) membrane the output voltage is enhanced from –127 to –568 mV and current output is increased from 10.2 to 51.5 µA.

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Garcinol in gastrointestinal cancer prevention: recent advances and future prospects

Patwa,

Chauhan,

Chauhan

et al. 2024

J Cancer Res Clin Oncol

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Gastrointestinal cancers continue to pose a significant global health challenge, with millions of new cases diagnosed each year. Despite advancements in treatment, the prognosis for many patients remains poor. This article explores the potential of garcinol, a polyisoprenylated benzophenone found in various Garcinia species, as a therapeutic agent against gastrointestinal malignancies. The objective is to review recent research on garcinol’s anticancer properties, its mechanisms of action, and safety aspects. Garcinol exhibits anticancer effects in esophageal, gastric, colorectal, pancreatic, and liver cancers by inhibiting metastasis, inducing apoptosis, and targeting key molecular pathways in cancer progression. Nanotechnology is explored as a means to enhance garcinol delivery and efficacy. Safety assessments suggest a promising toxicity profile. Garcinol shows significant potential as a natural therapeutic agent for gastrointestinal cancers, and future research is needed on optimizing its delivery, exploring synergistic combinations, and conducting clinical trials to validate its efficacy and safety for clinical applications.

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Garcinia morella fruit, a promising source of antioxidant and anti-inflammatory agents induces breast cancer cell death via triggering apoptotic pathway

Cited by 40 publications

References 51 publications

Chemical and Biological Aspects of Garcinol and Isogarcinol: Recent Developments

Chemical and Biological Aspects of Garcinol and Isogarcinol: Recent Developments

Synergetic Combination of Bio‐Electrolytes and Bio‐Fluidic Channels as a Novel Resource of Sustainable Energy

Garcinol in gastrointestinal cancer prevention: recent advances and future prospects

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