Garcinielliptone FC: Selective anti-amastigote and immunomodulatory effects on macrophages infected by Leishmania amazonensis

Bezerra, Érika Alves; Alves, Michel Muálem de Moraes; Amorim, Layane Valéria; Carvalho, Rita de Cássia Viana de; Cruz, Lucas Pereira Lima da; Costa-Júnior, Joaquim Soares da; Oliveira, Maria das Dores Alves de; Neto, José de Sousa Lima; Carvalho, Fernando Aécio de Amorim; Citó, Antônia Maria das Graças Lopes; Arcanjo, Daniel Dias Rufino

doi:10.1016/j.tiv.2019.104750

Cited by 9 publications

(7 citation statements)

References 34 publications

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“…Destaca-se que a investigação de novos fármacos oriundos de plantas vem favorecendo a descoberta de metabólitos com potencialidade terapêutica importante para o desenvolvimento de novos fitoterápicos, por intermédio do isolamento, do esclareci-mento da estrutura, da composição e análise da bioatividade (21) . Evidencia-se a busca constante por ensaios pré-clínicos robustos com plantas medicinais, no entanto, são limitadas pesquisas que abordem as atividades farmacológicas da manteiga de bacuri (Platonia insignis Mart.…”

Section: Discussionunclassified

Pharmacological actions of bacuri butter (Platonia insignis Mart.): an integrative review

Ribeiro¹,

Figueiredo²,

Carvalho³

et al. 2021

Rev Rene

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Objective: to identify the pharmacological activities of bacuri butter (Platonia insignis Mart.). Methods: an integrative review, carried out in the databases of Latin American and Caribbean Literature in Health Sciences, Cumulative Index to Nursing and Allied Health Literature, EMBASE, MEDLINE/PubMed, Web of Science, Cochrane Library and SCOPUS, without the time and language restriction. The selection consisted of 13 pre-clinical trials. The information assessment descriptively took place, comparing with the pertinent findings. Results: it was observed that 50.0% of the publications were indexed in MEDLINE/PubMed, most publications were from England (61.5%), followed by Brazil and the United States, both with 13.3%. It is noteworthy that 100.0% of the articles were pre-clinical trials; pharmacological activities for antioxidants (38.4%) and antileishmanicides (30.7%). It was found that 38.4% of the trials presented toxicity tests. Conclusion: bacuri butter (Platonia insignis Mart.) Showed pharmacological activities in pre-clinical trials, such as antioxidants, antileshimaniasis, anticonvulsant and wound healing.

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Section: Discussionunclassified

Pharmacological actions of bacuri butter (Platonia insignis Mart.): an integrative review

Ribeiro¹,

Figueiredo²,

Carvalho³

et al. 2021

Rev Rene

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“…Garcinielliptone FC ( 5 ), a prenylated benzophenone occurring naturally in Platonia insignis seeds, exhibited potent in vitro inhibition of the growth of L. amazonensis intracellular amastigotes, with IC 50 values of 1.91 μM. Compound 5 demonstrated a high selectivity for this parasite (Table 1) (Bezerra et al., 2020). Part of the activity of compound 5 is due to the presence of a prenyl group on the benzophenone ring, which facilitates attachment to cell membranes (Li et al., 2012).…”

Section: Anti‐leishmanicidal Activity Of Terpenesmentioning

confidence: 99%

Section: Terpenes Active Against Cutaneous Leishmaniasismentioning

confidence: 99%

Could natural terpenes be an alternative for the treatment of neglected tropical diseases?

Soto‐Sánchez

2024

Chem Biol Drug Des

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Existing chemotherapy for neglected tropical diseases (NTDs) can often be toxic and ineffective, highlighting the necessity for new treatments. Terpenes are secondary metabolites with pharmacological potential. This aim of this mini‐review is to explore the most promising natural terpenes with anti‐leishmanicidal, anti‐schistosomicidal, and anti‐echinococcal activity, their mechanisms of action, and their efficacy as combination therapy. The study identified a tetracyclic diterpenoid, a sesquiterpene lactone, and a triterpene with the highest biological activity against leishmaniasis. Additionally, a triterpenoid and a tetraterpene showed potent activity against schistosomiasis and echinococcosis, respectively. Compounds have antiparasitic effects by inducing cell death, inhibiting cell stress‐related proteins, degrading extracellular matrix, and modulating immune and inflammatory responses. The employment of combination therapy and terpene nanotransporters appears to enhance the antiparasitic activity of these compounds. Although identifying specific molecular targets is necessary, the use of terpenes in combination therapy presents a safe and highly promising approach for the rational development of more potent and selective antiparasitic drugs.

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“…They predominantly include free fatty acids (palmitic, oleic, linoleic, α-linolenic, stearic, caprylic and myristic acids), alcohols (e.g., linalool, α-terpineol and 3,7-dimethyl-oct-l-en-3,7-diol), oxides (e.g., cis-linalool oxide and trans-linalool oxide), trimethyl citrate and the phenolether eugenol (Monteiro et al, 1997). In contrast, the composition of P. insignis seed remains rather unknown; to date, a few acids (Bentes et al, 1986) and a compound garcinielliptone (Costa Júnior et al, 2011a;Bezerra et al, 2020) were described. The latter compound with important antiparasitic activity (Silva et al, 2015), antioxidant and anticarcinogenic activities (Costa Júnior et al, 2012), besides vasorelaxant effect (Arcanjo et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Genotoxic and cytotoxic activities of hexane extract in seeds from Platonia insignis Mart.

Oliveira

Alves

Sousa

et al. 2022

RSD

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Platonia insignis Mart. is a vegetable of the Clusiaceae Lindl., family that is popularly known as “bacuri” in Brazil. It is widely used in folk medicine to treat human diarrheas and inflammatory diseases. It has antiparasitic activity, antioxidant, anticarcinogenic action, in addition to vasorelaxant potential. The present study investigates the leishmanicidal, cytotoxic and genotoxic activities in different biological systems, as well as the chemical constituents of hexane extract from P. insignis seeds. The analysis of the non-volatile constituents was analyzed by GC/MS. A total of sixteen main constituents were detected in the saponifiable material (fatty acid methyl esters, ethyl ester, alcohols and hydrocarbons). In unsaponifiable fraction, nineteen constituents were detected, including a series of n-alkanes and prenylated xanthones gamma-mangostin as main component (70.23% of the total components). The results indicated that the seed hexane extract significantly inhibits the growth of promastigote forms of Leishmania amazonensis (IC50), displayed a significant toxicity against Artemia salina Leach and cytotoxicity and genotoxicity in V79 cell lines.

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Garcinielliptone FC: Selective anti-amastigote and immunomodulatory effects on macrophages infected by Leishmania amazonensis

Cited by 9 publications

References 34 publications

Pharmacological actions of bacuri butter (Platonia insignis Mart.): an integrative review

Pharmacological actions of bacuri butter (Platonia insignis Mart.): an integrative review

Could natural terpenes be an alternative for the treatment of neglected tropical diseases?

Genotoxic and cytotoxic activities of hexane extract in seeds from Platonia insignis Mart.

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