Gardasil Vaccination for Recurrent Laryngeal Papillomatosis in Adult Men

Makiyama, Kiyoshi; Hirai, Ryoji; Matsuzaki, Hiromi

doi:10.1016/j.jvoice.2016.01.008

Cited by 40 publications

(23 citation statements)

References 13 publications

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“…Another prime target population for vaccination would be pregnant women with clinically obvious HPV genital disease at some time during pregnancy, as their risk of having a child with RRP is 1/400. We suggest that our data, together with other published data17, 18, 19, 20, 21 support the need for a large multi‐center, adequately powered, randomized, and placebo‐controlled trial of vaccination in RRP patients which would definitively answer the question.…”

Section: Discussionsupporting

confidence: 72%

Recurrent respiratory papillomatosis (RRP)–time for a reckoning?

Goon

Scholtz²,

Sudhoff³

2017

Laryngoscope Investig Oto

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ObjectivesRecurrent respiratory papillomatosis (RRP) is a rare disease, but one with severe morbidity and occasional mortality. The aetiological agent is human papillomavirus (HPV), and HPV types 6 and 11 account for over 90% of all cases. In the active phase of the disease, patients require multiple hospital admissions for surgical removal or ablation of these benign tumors, which are likely to obstruct the airways if left unchecked. Long‐term sequelae include scarring of the vocal cords, change in voice timbre, or even muteness if a tracheostomy is required. The aim of this study was to determine if adjuvant vaccination with the quadrivalent HPV L1 vaccine (Gardasil™) would decrease numbers of surgical treatments post‐vaccination.MethodsA prospective pilot study following a cohort of 12 RRP patients, all of whom gave fully informed consent to participate. All patients had their papillomas typed and if they were found to have types 6 or 11, were vaccinated at the time of first surgical treatment in the hospital, according to the manufacturer's protocols. Patients were followed up closely with 3 or 6 month follow‐up visits. Standard surgical treatments were given and were not affected by whether they participated in the study.ResultsWe found a >7‐fold decrease in the incidence rates of papillomatosis requiring surgical intervention from the pre‐vaccination period (47.44/1000 patient‐months) compared to the post‐vaccination period (6.71/1000 patient‐months).DiscussionSurgical treatments for RRP are robust markers for papillomata which require treatment because of the dangers of obstruction of the airway. Despite the small size of this cohort (due to the rarity of this disease), the data suggests that adjuvant use of quadrivalent HPV L1 vaccine imparts significant benefit to this group of patients. A large multi‐center randomized placebo controlled trial is required to definitively establish whether this hypothesis is true and can become the new standard of therapy.Level of Evidence3b

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Section: Discussionsupporting

confidence: 72%

Recurrent respiratory papillomatosis (RRP)–time for a reckoning?

Goon

Scholtz²,

Sudhoff³

2017

Laryngoscope Investig Oto

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“…Furthermore, MSW are less knowledgeable about HPV than MSM [32]. Emerging research examining the benefits of HPV vaccine in adult males further emphasizes the significance of prioritizing related dissemination and awareness strategies for this population [33]. Other investigations, however, indicate that Black and Hispanic adolescent males and their parents place more importance on HPV vaccinations compared to White adolescent males and their parents [34,35].…”

Section: Discussionmentioning

confidence: 99%

HPV vaccine awareness and the association of trust in cancer information from physicians among males

Cooper

Hernandez

Rollins

et al. 2017

Vaccine

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Introduction Black and Hispanic men are diagnosed with more HPV-related cancers and at later stages compared to other racial/ethnic groups. Physician communication with men about HPV vaccination may be beneficial to increasing HPV vaccinations and decreasing HPV transmission. The purpose of this study was to examine HPV and HPV vaccine awareness among men by race, and the association between trust in cancer information from physicians and ever hearing about HPV and the HPV vaccine. Methods U.S. adult males (age 18+) were identified from the 2014 Health Information National Trends Survey (HINTS) (n = 1203). Binomial logistic regression models assessed the influences of race/ethnicity and trust of cancer information from physicians on men having heard of HPV and the HPV vaccination. Results Approximately 50% of the sample had never heard of HPV and 53% had never heard of the vaccine. Black men were less likely to know that HPV is sexually transmitted compared to White and Hispanic men (p < 0.001). Hispanic and Black men were less likely to have heard about the HPV vaccine when compared to White men (p < 0.001). Additionally, Hispanic men were less likely to trust a doctor about cancer information compared to White and Black men (p < 0.001). Conclusion Findings highlight the lack of awareness about HPV among men. Furthermore, statistically significant racial/ethnic differences were found in HPV vaccine knowledge and trust in receiving cancer information from physicians. Future interventions should include community-based approaches and improved physicians' HPV-related communication to increase knowledge and uptake of the HPV vaccine.

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“…Some surgeons have conducted such interventions under a research protocol and have published their observations. Several showed a serologic response [36,37] to the vaccine and an increase in the time between surgeries [5,6,38,39]. Hermann et al [7] and Milner et al [8]found no such difference.…”

Section: Plos Onementioning

confidence: 99%

In RRP, serologic response to HPV is frequently absent and slow to develop

et al. 2020

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BackgroundRecurrent respiratory papillomatosis (RRP) is characterized by repeated formation of papillomas in the respiratory tract and is caused by human papillomavirus (HPV) types 6 and 11. Women with genital HPV infection are slow to develop weak humoral immunity, but respond robustly to the HPV vaccine. We wondered if people with RRP had a similar immune response. MethodsA convenience cross-sectional sample of patients with RRP were recruited into one of four groups: 1) adults and adolescents with active RRP, 2) children with active RRP, 3) RRP patients who had undergone HPV vaccination prior to enrollment and, 4) people with RRP who were in remission. Anti-HPV6 and HPV11 serology was determined by cLIA on a single blood draw. OPEN ACCESS Citation: Buchinsky FJ, Ruszkay N, Valentino W, Derkay CS, McClay JE, Bastian RW, et al. (2020) In RRP, serologic response to HPV is frequently absent and slow to develop. PLoS ONE 15(3): e0230106. https://doi. ConclusionPeople with RRP are capable of developing a humoral response to HPV6 and HPV11. That response appears to be robust when initiated by the HPV vaccine, but either nonexistent or slow to develop in response to infection. Most in remission do not have demonstrable antibody levels against HPV6 or HPV11.

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Gardasil Vaccination for Recurrent Laryngeal Papillomatosis in Adult Men

Cited by 40 publications

References 13 publications

Recurrent respiratory papillomatosis (RRP)–time for a reckoning?

Recurrent respiratory papillomatosis (RRP)–time for a reckoning?

HPV vaccine awareness and the association of trust in cancer information from physicians among males

In RRP, serologic response to HPV is frequently absent and slow to develop

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