Gardner syndrome with odontogenic sinusitis: A case report

Saito, Kosuke; Sekine, Motoki; Goto, Fumiyuki; Yamamoto, Hikaru; Kaneda, Shoji; Sakai, Akihiro; Iijima, Hiroaki; Yamauchi, Mayu; Yamazaki, Aritomo; Okami, Kenji

doi:10.1002/ccr3.4256

Cited by 5 publications

(8 citation statements)

References 4 publications

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“…However, some of them are associated with GS [16]. Osteomas appear 4-20 times more often in GS patients than in healthy population, and are most often localized in the mandible [8,11]. Therefore, they can also occur in the paranasal sinuses, the jaw?, the skull, or even the long bones [11].…”

Section: Discussionmentioning

confidence: 99%

“…As polyposis remains asymptomatic, it is very difficult to set the proper diagnosis when no extraintestinal manifestation or family history are present [7]. In patients with APC mutation there is a high risk of CRC, gastric cancer, duodenal cancer, thyroid cancer, and malignant dental tumours [8]. Therefore, these patients require long-term follow-up [8].…”

Section: Introductionmentioning

confidence: 99%

“…In patients with APC mutation there is a high risk of CRC, gastric cancer, duodenal cancer, thyroid cancer, and malignant dental tumours [8]. Therefore, these patients require long-term follow-up [8].…”

Section: Introductionmentioning

confidence: 99%

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Gardner syndrome with desmoid tumors – case report

Rycyk,

Knop-Chodyła,

Kasztelan-Szczerbińska

et al. 2024

J Pre Clin Clin Res.

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Introduction. Gardner syndrome (GS) is characterized as a type of familial adenomatous polyposis (FAP), an autosomal dominant inherited disease which, if left untreated, with 100% risk leads to the development of colorectal cancer. Case Report. The case is presented a of a 40-year-old man who was diagnosed with Gardner syndrome at the age of 12. During his hospitalization, the patient underwent gastroscopy, colonoscopy, and computed tomography (CT) scans of head, neck and abdomen. The examination revealed the presence of extra-intestinal manifestations of GS: desmoid tumours, osteomas, and dental cavities. At present, the patient is scheduled for enteroscopy. Conclusions. GS is a diagnosis of genetic testing, although clinicians should be aware of the fact that up to 30% of GS cases are detected as de novo mutations. The physical examination should always be performed with accuracy to avoid a too late diagnosis of FAP, including GS, which may result in death.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gardner syndrome with desmoid tumors – case report

Rycyk,

Knop-Chodyła,

Kasztelan-Szczerbińska

et al. 2024

J Pre Clin Clin Res.

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“…When tumors involve the skull base, complications include the presence of an accompanying subdural empyema, 72 intradural mucoceles, 134 and odontogenic sinusitis. 135 Multiple copresenting nonsyndromic 136,137 and syndromic osteomas 135,138,139 also add to the complexity of treatment. In addition, giant cranial osteomas can be especially difficult due to their size and tendency to compress critical craniofacial structures and outflow tracts.…”

Section: Prognosismentioning

confidence: 99%

“…When tumors involve the skull base, complications include the presence of an accompanying subdural empyema, 72 intradural mucoceles, 134 and odontogenic sinusitis 135 . Multiple copresenting nonsyndromic 136,137 and syndromic osteomas 135,138,139 also add to the complexity of treatment.…”

Section: Prognosismentioning

confidence: 99%

Diagnosis and Management of Craniofacial Osteomas

Langlie

Hullfish

Jabori

et al. 2023

Journal of Craniofacial Surgery

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Importance: Osteoid osteomas are benign bony overgrowths that can occur in any region of the body. However, they have a predilection to occur in the craniofacial region. Because of the rarity of this entity, there is a lack of literature detailing the management and prognosis of craniofacial osteoid osteomas. Observations: Craniofacial osteomas have a predilection to involve the paranasal sinuses, but can also be found within the jaw, skull base, and facial bones. Because of their slow-growing nature, craniofacial osteomas are often incidentally discovered on routine imaging or after they compress nearby structures or distort nearby anatomy. Osteoid osteomas of the face can be treated with resection via various approaches. Recent advancements describe minimally invasive endoscopic techniques and adjuvant therapy with radiofrequency ablation guided by cone biopsy computed tomography. Osteoid osteomas have an excellent prognosis with complete resection. They demonstrate a low incidence of recurrence when compared with other osteoblastic lesions of the craniofacial structures. Conclusions and Relevance: Craniofacial osteoid osteomas remain a developing topic within the field of craniofacial surgery. Their removal may be trending toward minimally invasive techniques. However, all treatment modalities appear to result in improved cosmetic outcomes and low recurrence rates.

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