Garlic: A review of its relationship to malignant disease

Dausch, Judith G.; Nixon, Daniel W.

doi:10.1016/0091-7435(90)90034-h

Cited by 137 publications

(52 citation statements)

References 51 publications

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“…Moreover, DADS is the major component of cooked garlic, which is reduced to allyl mercaptan in blood (21). DADS is reported to make up about 60% of garlic oil (22), thus, indicating that it is the most appropriate compound to use in the study of the possible effects of raw and cooked garlic in humans. Studies have shown that DADS suppresses the proliferation of cancer cells such as MGC803, SW480, and HL-60-cultured cells (9,23,24).…”

Section: Discussionmentioning

confidence: 99%

Growth inhibitory effect and Chk1-dependent signaling involved in G2/M arrest on human gastric cancer cells induced by diallyl disulfide

Ling

Wen

et al. 2010

Braz J Med Biol Res

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Section: Discussionmentioning

confidence: 99%

Growth inhibitory effect and Chk1-dependent signaling involved in G2/M arrest on human gastric cancer cells induced by diallyl disulfide

Ling

Wen

et al. 2010

Braz J Med Biol Res

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“…Increasing evidences has suggested that the mechanism of anti-cancer action of garlic compounds may involve modulation of signal transduction pathways (23). Diallyl sulfide (DAS), one of the component of garlic, has been reported to act as a potential chemopreventive function for many human cancer such as colon, lung, and skin (24). In our earlier studies, DAS inhibited the N-acetyltransferase activity in bacteria (25,26), human colon cancer cells (27) and bladder cancer cells (28), and inhibits murine WEHI-3 leukemia cells in BALB/c mice in vitro and in vivo (29).…”

Section: Introductionmentioning

confidence: 99%

Diallyl sulfide induces cell cycle arrest and apoptosis in HeLa human cervical cancer cells through the p53, caspase- and mitochondria-dependent pathways

Chung

Liu

et al. 2011

Int J Oncol

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Abstract. Diallyl sulfide (DAS), one of the main active constituents of garlic, causes growth inhibition of cancer cells in vitro and promotes immune responses in vivo in experimental settings. However, its effects on the induction of cell cycle and apoptosis in human cervical cancer cells are still unclear. The aims of this study were to explore the anti-cancer effects of DAS in HeLa human cervical cancer cells and to investigate the underlying mechanisms in vitro. Cytotoxicity and apoptosis in HeLa human cervical cancer cells were examined by the morphological changes, viability assay, 4',6-Diamidino-2-phenylindole dihydrochloride (DAPI) staining, comet assay, Western blotting and confocal microscopy examination. The results showed that DAS treatment for 24-72 h resulted in a marked decrease in cell viability time-and dose-dependently. Flow cytometric analysis showed that a 48-h treatment of 75 µM DAS induced G0/G1 cell cycle arrest and sub-G1 phase (apoptosis) in HeLa cells. Typical apoptotic nucleus alterations were observed by fluorescence microscopy in HeLa cells after exposure to DAS using DAPI staining. Cells treated with different concentrations of DAS also showed changes typical of apoptosis such as morphological changes, DNA damage and fragmentation, dysfunction of mitochondria, cytochrome c release and increased expression of pro-caspase-3 and -9. DAS also promoted the release of AIF and Endo G from mitochondria in HeLa cells. In conclusion, DAS induced G0/G1 cell cycle arrest and apoptosis in HeLa cells through caspase-and mitochondria and p53 pathways providing further understanding of the molecular mechanisms of DAS action in cervical cancer. This study, therefore, revealed that DAS significantly inhibits the growth and induces apoptosis of human cervical cancer HeLa cells in vitro.

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“…실제로 여러 가지 질병을 예방 하고 치료하는데 효과가 있어 많은 연구의 대상이 되고 있는 데, 이는 마늘이 함유하고 있는 다량의 유기 황화합물 (organosulfur compounds) 때문인 것으로 알려지고 있다 [5,10]. 특히, diallyl disulfide (DADS)는 마늘의 주요한 유기 황화합물 성분으로서 화학적 간독성에 대한 보호와 [17,28] 항 박테리아 [3] 및 항동맥경화 [19] 등에 효과를 보이는 것으로 보 고되고 있다.…”

Section: 서 론unclassified

Effect of Diallyl Disulfide on Heme Oxygenase-1 Expression in Human Hepatoma Cell Line HepG2

Kim¹,

Lee²,

Park³

2011

Journal of Life Science

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Diallyl disulfide (DADS), the most prevalent oil-soluble organosulfur compound in garlic, is known to have diverse biological activities, including anticarcinogenic, antiatherosclerotic, antiinflammatory, and antioxidant actions. In this study, we investigated the effect of DADS on the expression of heme oxygenase-1 (HO-1) in human liver hepatoma cell line HepG2. Treatment of HepG2 cells by DADS evoked a dose-dependent growth inhibition without significant toxicity to the cells, and also induced the expression of transcription factor Nrf2.

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Garlic: A review of its relationship to malignant disease

Cited by 137 publications

References 51 publications

Growth inhibitory effect and Chk1-dependent signaling involved in G2/M arrest on human gastric cancer cells induced by diallyl disulfide

Growth inhibitory effect and Chk1-dependent signaling involved in G2/M arrest on human gastric cancer cells induced by diallyl disulfide

Diallyl sulfide induces cell cycle arrest and apoptosis in HeLa human cervical cancer cells through the p53, caspase- and mitochondria-dependent pathways

Effect of Diallyl Disulfide on Heme Oxygenase-1 Expression in Human Hepatoma Cell Line HepG2

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