Garlic (Allium sativum L.): a potential unique therapeutic food rich in organosulfur and flavonoid compounds to fight with COVID-19

Khubber, Sucheta; Hashemifesharaki, Reza; Mohammadi, Mehrdad; Gharibzahedi, Seyed Mohammad Taghi

doi:10.1186/s12937-020-00643-8

Cited by 103 publications

(64 citation statements)

References 8 publications

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“…Organosulfurs and flavonoids are found to be the predominant bioactives behind the immunomodulatory nature of Allium sativum. By forming the hydrogen bonds with the active sites of serine protease these bioactives may inhibit the COVID-19 outbreak [113]. Furthermore, a study demonstrated that alliin, SAC and other bioactive compounds of Allium sativum, can be employed as a potential inhibitor candidate for COVID-19 and could be beneficial in combating this pandemic [114].…”

Section: Anti-viral Potential Of Allium Sativummentioning

confidence: 99%

Phytotherapy for treatment of cytokine storm in COVID-19

Sapra,

Bhardwaj,

Azam

et al. 2021

Front. Biosci. (Landmark Ed)

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In 2020, a novel strain of coronavirus has led to a significant morbidity and mortality worldwide. As of the date of this writing, a total of 116 M cases has been diagnosed worldwide leading to 2.5 M deaths. The number of mortalities is directly correlated with the rise of innate immune cells (especially macrophages) in the lungs that secrete inflammatory cytokines (IL-1β and IL-6) leading to the development of "Cytokine Storm Syndrome" (CSS), multi-organ-failure and death. Given that currently the treatment of this condition is rare and release of effective vaccine might be months away, here, we review the plants and their pharmacologically active-compounds as potential phytopharmaceuticals for the virus induced inflammatory response. Experimental validation of the effectiveness of these natural compounds to prevent or reduce the cytokine storm might be beneficial as an adjunct treatment of SARS-CoV-2.

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Section: Anti-viral Potential Of Allium Sativummentioning

confidence: 99%

Phytotherapy for treatment of cytokine storm in COVID-19

Sapra,

Bhardwaj,

Azam

et al. 2021

Front. Biosci. (Landmark Ed)

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“…Laranja Excesso de frutose, que é convertido em gordura pelo fígado, a qual pode se acumular nas artérias e ocasionar problemas cardíacos, além de problemas estomacais, como úlceras. Não obstante, o problema maior das fake news estudadas se refere à substituição dos fármacos que realmente tratam os sintomas da doença pelos chamados remédios caseiros, que apenas têm efeitos auxiliares (KHUBBER et al, 2020;SILVA et al, 2020).…”

Section: Efeitos Adversos Fonteunclassified

“…Conforme descrito por Galhardi e colaboradores (2020), tal disseminação de fake news contribui para o descrédito da ciência e das instituições globais de saúde em favor do achismo. De fato, entre as principais fake news citadas pelos autores, temos em comum o uso do alho em água fervida, que até hoje não possui comprovação de eficácia no tratamento direto do coronavírus, servindo apenas como adjuvante ao estimular o sistema imunológico (KHUBBER et al, 2020;ROUF et al, 2020;SINGH;SAHU, 2020).…”

Section: Efeitos Adversos Fonteunclassified

O impacto das fake news em tempos de pandemia da COVID-19 - uma investigação das informações disseminadas através das mídias sociais sobre o uso de plantas medicinais

Silva¹,

Silva²,

Vampre³

et al. 2021

Rev Agr Acad

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The present article deals with the dissemination of fake news about the use of medicinal plants "capable" of curing and treating the symptoms of COVID-19. Through research on websites, six fake news related to supposed cures, published between 2020 and 2021, were selected, with subsequent textual analysis of each one, whose objective was to distinguish the true facts from the false ones. The results of the research indicate that according to the scientific literature, six of the nine plants used for treatment have active ingredients that are toxic if consumed exaggeratedly. It is concluded that medicinal plants should be used only as a vitamin supplement, capable of helping to strengthen the immune system.

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“…It may attenuate immune system-related dysfunctions seen in patients with COVID-19 infection [ 64 ]. Aqueous extracts and essential oils of AS showed interaction with M pro protease of SARS-CoV-2 and reduced the rate of viral infection caused by SARS-CoV-2 [ 65 , 66 ]. The encapsulation of these active constituents by using different methods can improve their oxidative stability and bio-functionality and may offer targeted drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Allium sativum derived carbon dots as a potential theranostic agent to combat the COVID-19 crisis

Kalkal

Allawadhi

Pradhan

et al. 2021

Sensors International

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Coronavirus disease 2019 (COVID-19) is one of the worst pandemics to have hit humanity. The manifestations are quite varied, ranging from severe lung infections to being asymptomatic. Hence, there is an urgent need to champion new tools to accelerate the end of this pandemic. Compromised immunity is a primary feature of COVID-19. Allium sativum (AS) is an effective dietary supplement known for its immune-modulatory, antibacterial, anti-inflammatory, anticancer, antifungal, and anti-viral properties. In this paper, it is hypothesized that carbon dots derived from AS (AS-CDs) may possess the potential to downgrade the expression of pro-inflammatory cytokines and revert the immunological aberrations to normal in the case of COVID-19. Carbon dots (CDs) have already been explored in the world of nanobiomedicine as promising theranostic candidates for bioimaging and drug/gene delivery. The antifibrotic and antioxidant effects of AS are elaborated, as demonstrated in several studies. It is found that the most active constituent of AS, allicin has a highly potent antioxidant and reactive oxygen species (ROS) scavenging effect. The antibacterial, antifungal, and anti-viral effects along with their capability of negating inflammatory effects and cytokine storm, are discussed. The synthesis of theranostic CDs from AS may provide a novel weapon in the therapeutic armamentarium for the management of COVID-19 infection and, at the same time, could act as a diagnostic agent for COVID-19.

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Garlic (Allium sativum L.): a potential unique therapeutic food rich in organosulfur and flavonoid compounds to fight with COVID-19

Cited by 103 publications

References 8 publications

Phytotherapy for treatment of cytokine storm in COVID-19

Phytotherapy for treatment of cytokine storm in COVID-19

O impacto das fake news em tempos de pandemia da COVID-19 - uma investigação das informações disseminadas através das mídias sociais sobre o uso de plantas medicinais

Allium sativum derived carbon dots as a potential theranostic agent to combat the COVID-19 crisis

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