Garlic-derived exosomes carrying miR-396e shapes macrophage metabolic reprograming to mitigate the inflammatory response in obese adipose tissue

Bian, Yangping; Li, Weizhao; Jiang, Xiaoqing; Yin, Fei; Li, Yin; Zhang, Yonglan; Guo, Hong; Liu, Jianhui

doi:10.1016/j.jnutbio.2022.109249

Cited by 8 publications

(1 citation statement)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ginger is a plant of Zingiberaceae, which contains volatile oil, gingerol, flavonoids, and other components, and has anti‐inflammatory, anti‐tumor, and digestive effects [135]. Garlic ELNs can regulate the expression of inflammatory factors released by macrophages by their anti‐inflammatory properties, and improve fatty degeneration and inflammatory reaction of the liver caused by obesity through crosstalk between macrophages and hepatocytes [136]. The exosome nanoparticles separated from grapes can treat intestinal inflammation [48].…”

Section: Functions and Application Of Pensmentioning

confidence: 99%

A review on separation and application of plant‐derived exosome‐like nanoparticles

Liu,

Xiao,

Wang

et al. 2024

J of Separation Science

View full text Add to dashboard Cite

Exosomes‐like nanoparticles (ELNs) (exosomes or extracellular vesicles) are vesicle‐like bodies secreted by cells. Plant ELNs (PENs) are membrane vesicles secreted by plant cells, with a lipid bilayer as the basic skeleton, enclosing various active substances such as proteins and nucleic acids, which have many physiological and pathological functions. Recent studies have found that the PENs are widespread within different plant species and their biological functions are increasingly recognized. The effective separation method is also necessary for its function and application. Ultracentrifugation, sucrose density gradient ultracentrifugation, ultrafiltration, polymer‐based precipitation methods, etc., are commonly used methods for plant exosome‐like nanoparticle extraction. In recent years, emerging methods such as size exclusion chromatography, immunoaffinity capture‐based technique, and microfluidic technology have shown advancements compared to traditional methods. The standardized separation process for PENs continues to evolve. In this review, we summarized the recent progress in the biogenesis, components, separation methods, and some functions of PENs. When the research on the separation method of PENs and their unique biological structure is further studied. A brand‐new idea for the efficient separation and utilization of PENs can be provided in the future, which has a very broad prospect.

show abstract

Section: Functions and Application Of Pensmentioning

confidence: 99%