2021
DOI: 10.2147/jir.s339092
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Garlic Extract Alleviates Trastuzumab-Induced Hepatotoxicity in Rats Through Its Antioxidant, Anti-Inflammatory, and Antihyperlipidemic Effects

Abstract: Background: Trastuzumab is a new biological drug that has been used to treat breast and gastric cancer; however, its cardiotoxicity and hepatotoxicity limit its use. Garlic has antioxidant, anti-inflammatory, antihyperlipidemic, and anticancer effects. The present study aimed to evaluate the effects of garlic on trastuzumab-induced hepatotoxicity in a rat model. Methods: Twenty rats were divided into four equal groups as vehicle control (G1), garlic (G2), trastuzumab (G3), and trastuzumab+garlic (G4). All rats… Show more

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Cited by 6 publications
(2 citation statements)
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“…Allium sativum has traditionally been associated with beneficial effects in infectious processes due to its antimicrobial, anti-inflammatory, and antioxidant properties [ 6 , 17 , 31 , 32 ]. However, it has not yet been introduced in clinical settings.…”
Section: Discussionmentioning
confidence: 99%
“…Allium sativum has traditionally been associated with beneficial effects in infectious processes due to its antimicrobial, anti-inflammatory, and antioxidant properties [ 6 , 17 , 31 , 32 ]. However, it has not yet been introduced in clinical settings.…”
Section: Discussionmentioning
confidence: 99%
“…Unusual aspects, such as sinusoidal obstruction syndrome (SOS), have been reported in rare cases, emphasizing the need for careful hepatic monitoring during trastuzumab treatment (106). Additionally, garlic has demonstrated hepatoprotective effects against trastuzumab-induced toxicity, mitigating structural changes, inflammation, and oxidative stress in rat liver tissues (107).…”
Section: Antitumor Antibodiesmentioning
confidence: 99%