Garlic Lowers Blood Pressure and Reduces Oxidative Stress by Increasing Plasma H2s Content in Patients With Arterial Hypertension

Abstract

Arterial hypertension (AH) is a multifactorial disease that is accompanied by the development of oxidative-nitrosative stress and insufficient production of hydrogen sulfide (H2S). We hypothesized that garlic bio supplement Full Spectrum Garlic (Swanson Health Product, USA) may be used as a potential H2S donor in treatment of AH in patients. The aim was to study the effect of garlic on blood pressure, ROS generation and cNOS/iNOS activity, biochemical in male 28-39 years old patients with grade II AH. It was found that 10 days of standard antihypertensive therapy (adrenoblockers, ACE inhibitors) with 30 days of garlic supplementation reduced mean systolic and diastolic pressures by 9 and 8 mm Hg respectively. Positive effects of garlic consumption on hemodynamic parameters were observed: enddiastolic volume increased by 8% and peripheral vascular resistance decreased by 11,3% . In the blood plasma of patients, H2S levels increased by 43,6% , the production of ROS and the content of lipid peroxidation products decreased significantly. It is important that the cNOS activity was increased by 130% and iNOS activity decreased by 38,3%. No significant changes in cholesterol, urea, creatinine, glucose, as well as erythrocyte parameters were observed, which indicates the tolerance of the garlic supplements. Thus, the hypotonic effect of garlic is realized by increasing endogenous H2S in plasma, improving endothelium-dependent relaxation of blood vessels and reducing the manifestations of oxidative stress, which makes it promising to use it in the complex therapy of hypertension.

Garlic supplement lowers blood pressure in 40-60 years old hypertensive individuals, regulates oxidative stress, plasma cholesterol and protrombin index

“…Previously we showed that garlic supplement consumption for 30 days provided antioxidant and hypotensive effects in patients aged 20-39 years with grade II hypertension [20]. We have found the normalization of plasma H 2 S levels and restoration of constitutive NO synthesis.…”

“…In the present study, we tested the ability of garlic supplement to improve the functional parameters of the that was even greater than in younger patients (by 9 and 8 mm Hg) [20]. It is important to note that the hypotensive effect of the garlic was realized due to the reduction of oxidative stress and decrease of the peripheral vascular resistance.…”

“…Citation: Kravchuk level, prothrombin index, as well as the number of leukocytes in the blood serum after garlic consumption [20].…”

“…It has been shown that some active components of garlic have the ability to scavenge radicals oxygen species, thus realizing their antioxidant action [18,19]. Previously we showed the positive effect of long-term use of garlic on the functional parameters of the cardiovascular system in young hypertensive patients [20]. The aim of the present work was study the effect of garlic supplementation on biochemical parameters of blood, markers of oxidativenitrosative stress, arterial blood pressure and vessels resistance in elderly hypertensive patients.…”

The Hypotensive Activity of Diferent Fractions of the Extracts From Tissue Culture Biomass of Rauwolfia Serpentina Benth

“…артеріальна гіпертензія залишається провідною медико-соціальною проблемою внаслідок значної розповсюдженості. Сучасний арсенал лікарських засобів для лікування серцево-судинних захворювань надзвичайно великий, однак важливим завданням є пошук перспективних біологічно активних сполук рослинного походження, які б мали гіпотензивну дію та мінімальні побічні ефекти [1,2].…”