Garlic oil–loaded PLGA nanoparticles with controllable size and shape and enhanced antibacterial activities

Abstract

The present work focuses on producing polymer composite nanoparticles (NPs) composed of garlic oil (GO) and poly (lactic-co-glycolic) acid (PLGA) by the single emulsion/solvent evaporation (SE/SE) method and high-speed homogenizing. Different preparation parameters were found to greatly affect the stability and size uniformity of the prepared PLGA/GO NP formulations, which were carefully controlled. Scanning electron microscopy, Fourier transform infrared spectroscopy, and UV-vis spectroscopy and dynamic light scattering and zeta potential were used to characterize the NPs. Antibacterial assessment of the prepared PLGA/GO NPs against E. coli and S. aureus was carried out. Interestingly, the NP size ranged between 201 and 319 nm, which is 10 times less than the size of the regular GO particles in bulk solution. The antibacterial activities show enhancement by 70-78% of bacterial inhibition compared with a GO bulk solution. This work sheds light on the potential use of GO NP formulations as nanobiotics and the critical NP preparation parameters that need to be considered.

Palladium Nanoparticles Fabricated by Green Chemistry: Promising Chemotherapeutic, Antioxidant and Antimicrobial Agents

“…Some plants also possess therapeutic actions such as antimicrobial, anticancer, or antioxidant activities. Hence, they impart a synergistic therapeutic effect upon their combination with Pd NPs [ 24 , 25 ].…”

“…Furthermore, the phytosynthesis process can easily be optimized for large-scale production of more stable Pd NPs. On the other hand, plant extracts harbor various bioactive metabolites that could act as natural reducing and capping agents during the phytosynthesis of Pd NPs [ 22 , 23 , 24 , 25 ]. To achieve phytosynthesis, sonication, microwave, magnetic, and hydrothermal methods are employed along with non-hazardous solvents and lower temperatures [ 7 ].…”

PLGA nanoparticle preparations by emulsification and nanoprecipitation techniques: effects of formulation parameters

“…24 Several works analyze the experimental parameters of different techniques for the encapsulation of specic drugs. [25][26][27][28][29][30][31][32][33][34] The effect of some formulation parameters on the size of PLGA nanoparticles encapsulating bovine serum albumin, prepared by double emulsion solvent evaporation method, indicate that PLGA and PVA concentrations have a direct effect on the particle size. 35 Halayqa and Domańska analyzed the effect of some parameters in the emulsion-evaporation technique to improve the efficiency of encapsulation and size in the preparation of PNP loaded with perphenazine and chlorpromazine hydrochloride.…”

Peganum harmala Alkaloids Self-Assembled Supramolecular Nanocapsules with Enhanced Antioxidant and Cytotoxic Activities

“…Many studies have been reported on this path on employing natural products to treat several diseases. 14 , 15 …”