Abstract-Experimental study was conducted to investigate the influence of the injection timing on the performance and exhaust emissions of an electronic control high-pressure common rail turbocharged direct injection diesel engine fueled with isopropanol. Diesel fuels with different amounts (0%, 5%, 10%, 15% and 20% by volume) of isopropanol were used. The results show that the isopropanol addition can significantly improve soot and CO emissions. Under the same injection timing, with the increase of isopropanol blending ratio, combustion duration shortened, brake specific fuel consumption increased, the peak of in-cylinder pressure and heat release rate of pilot-injection combustion decreased, the peak of in-cylinder pressure and heat release rate of main-injection combustion increased, THC and NOx emissions increased. With the injection timing retarded, the center of heat release rate of pilot and main injection combustion delayed, the peak of in-cylinder pressure and heat release rate of former ascended, the latter descended. Brake specific fuel consumption, CO emission, THC emission and soot emission reduced, NOx emissions increased.