Gas chromatographic behavior of long chain alcohols and their derivatives

Extracts of marine species from Baja California and theCaribbean have been examined on shipboard for a variety of bioactlvities and their constituents studied there by gas chromatography! mass spectrometry. A very high proportion of the extracts has been shown to be cytotoxic, a high proportion to be antibacterial or antifungal and a surprisingly large number to be antiviral. Many of these activities have been confirmed in more extensive assays against tumor cells, pathogenic microorganisms and a battery of viruses. A number of the compounds responsible for the activities have been identified, including several new compounds. Of special current interest are the didemnins, depsipeptides isolated from a didemnid tunicate, which inhibit a number of RNA and DNA viruses and exhibit potent cytotoxicity vs. tumor cell lines.

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“…31), comparing retention times to those of a series of alkanes, as an aid to characterizing marine metabolites in the field (Ref. 32).…”

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confidence: 99%

Marine natural products as sources of antiviral, antimicrobial, and antineoplastic agents

Rinehart¹,

Shaw²,

Shield³

et al. 1981

Pure and Applied Chemistry

153

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“…In the above chromatogram, each oligomer is split into two peaks due to the formation of anomers. We have used the a-components of this mixture as markers for a "glucose unit" (GU), in a way similar to the "methylene units" used in gas chromatography [18,19].…”

Section: Resultsmentioning

confidence: 99%

Nitrogen‐selective detection in capillary supercritical fluid chromatography of derivatized oligosaccharides

Shirota¹,

Liu²,

Novotný³

1991

J Microcolumn Separations

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Abstract. Methoximation of reducing oligosaccharides, combined with the additional derivatization of hydroxy groups, yields derivatives suitable for capillary supercritical fluid chromatography with thermionic detection. Detection limits on the order of picogram-per-second can easily be achieved. The utility of this analytical procedure has been verified by the analysis of the carbohydrate content of chicken trypsin inhibitor.

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“…Methyl esters of palmitic, stearic, oleic, linoleic, linolenic and arachidonic fatty acids (The Hormel Institute, Austin, Minn.) were used for the identification of gas liquid chromatography (GLC) peaks of methyl esters prepared from sample fractions. A portion of the methyl ester standards was reduced with LiAIH 4 (8) and the resulting alcohols were acetylated (9). These alcohol acetates served as standards for the identification of GLC peaks of the alcohol acetates prepared from sample fractions.…”

Section: Methodsmentioning

confidence: 99%

“…The alcohol bands (derived from the reduction of the esterified acids) and the alk-l'-enyl glycerol ether band from the phosphatidylethanolamine were recovered. The alcohols were eluted from the silica gel using 20% methanol in dietlylether and acetylated (9). The acetylatedalcohols were purified by TLC using hexane-diethylether 90:10 v/v as the developing solvent.…”

Section: Quantitation and Analysis Of Glyceryl Ethersmentioning

confidence: 99%

Structural comparison between triglycerides and phospholipids from pig kidney

Hagen

1971

Lipids

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The compositional specificity of the major diacyl phosphatides, plasmalogens and triglycerides of pig kidney has been determined. The triglycerides have been shown to be esterified predominantly with saturated fatty acids in the 2 position while the phosphatides have predominantly unsaturated fatty acids in this position. Such complete "inversion" of the structure of triglycerides and phospholipids is not normally seen in mammalian tissue and suggests that the synthesis of structural polar lipids involves other steps than the reaction of a diglyceride with CDP-ethanolamine or CDP-choline. This marked difference in the fatty acid distribution of the polar lipids and triglycerides of the pig kidney may render this tissue especially suitable for studies on the turnover and synthesis of structural lipids.

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Gas chromatographic behavior of long chain alcohols and their derivatives

Cited by 60 publications

References 14 publications

Marine natural products as sources of antiviral, antimicrobial, and antineoplastic agents

Marine natural products as sources of antiviral, antimicrobial, and antineoplastic agents

Nitrogen‐selective detection in capillary supercritical fluid chromatography of derivatized oligosaccharides

Structural comparison between triglycerides and phospholipids from pig kidney

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