Gas chromatographic determination of mefloquine in human and dog plasma using electron-capture detection

Dadgar, Darioush; Climax, J.; Lambe, R.; Darragh, A.

doi:10.1016/0378-4347(85)80006-2

Cited by 21 publications

(2 citation statements)

References 8 publications

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“…As well, analytical applications of CMEs can require diffusion of analyte into the film, and this may be hindered by low diffusion coefficients for mass transport, Dmt (6)(7)(8)(9)(10). Increasing the extent of solvent swelling of the polymer matrix (11,12) and inducing heterogeneity in the polymer film through the use of polymer mixtures (13) are two methods that have been found to increase both Dct and Dmt. Miller and Majda (14,15) have reported that lateral charge transport in bilayer assemblies can be increased in the presence of octanol in solution and suggest this is due in part to increased fluidity of the bilayer when octanol is intercalated.…”

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confidence: 99%

Salicylate-selective membrane electrode based on tin(IV)-tetraphenylporphyrin

Chaniotakis¹,

Park²,

Meyerhoff³

1989

Anal. Chem.

211

146

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The response properties of a new solvent/polymeric membrane electrode with unique selectivity toward anionic salicylate are reported. The electrode is prepared by incorporating 5, 10, 15, 20-tetraphenyl(porphyrinato)tin(IV) dichloride (Sn[TPP]Cl2) into a plasticized poly(vinyl chloride) membrane. The resulting sensor exhibits an anti-Hofmeister selectivity pattern, with high specificity for salicylate over lipophilic inorganic anions (perchlorate, periodate, thiocyanate, iodide, etc.) and biological organic anions (citrate, lactate, acetate). Moderate selectivity over structural analogues of salicylate (3- and 4-hydroxybenzoate, benzoate) is also observed. Radiotracer uptake experiments using [14C]salicylate clearly show that the metal center of the metalloporphyrin is critical for selective salicylate transport in the membrane phase. Minimal response to chloride ions makes the new electrode potentially useful for estimating salicylate levels in biological samples.

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confidence: 99%

Salicylate-selective membrane electrode based on tin(IV)-tetraphenylporphyrin

Chaniotakis¹,

Park²,

Meyerhoff³

1989

Anal. Chem.

211

146

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“…Different methods of analysis had been reported such as spectrophotometry [7], fluorimetry [8], HPLC [9 -21] and gas chromatography [22,23]. Most of them are complicated, time consuming and need sophisticated equipments such as HPLC or gas chromatography.…”

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confidence: 99%

Voltammetric Investigation and Determination of Mefloquine

2005

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The electrochemical reduction behavior of mefloquine HCl (MEF), the antimalarial drug, was studied in aqueous alcoholic media at a hanging mercury drop electrode. Cyclic voltammetric studies showed one well-defined reduction peak and one ill-defined reduction wave between pH 1.5 and 12.03. The reduction was found as irreversible or quasireversible depending on pH and exhibited diffusion controlled process. The mechanism of reduction process was discussed. A systematic study of the experimental parameters that affect the differential pulse and square wave response was carried out and the optimized experimental conditions were obtained. The calibration plots were derived for the determination of MEF in pharmaceutical dosage forms and biological samples. DPV and SWV techniques for the determination of MEF in Britton -Robinson buffer at pH 11.10, which allows quantitation over the 6 Â 10 À6 to 8 Â 10 À5 M range in the supporting electrolyte, were proposed. The linear response was obtained in samples in the ranges of 6 Â 10 À6 to 6 Â 10 À5 M for both techniques. These methods are fully validated. The standard addition method was used in the biological media. No electroactive interferences from the excipients and endogenous substances were found in tablets and biological fluids.

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Validationof chromatographic methods of analysis of drugs in biological samples

Dadgar¹,

Smyth²

1986

TrAC Trends in Analytical Chemistry

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Gas chromatographic determination of mefloquine in human and dog plasma using electron-capture detection

Cited by 21 publications

References 8 publications

Salicylate-selective membrane electrode based on tin(IV)-tetraphenylporphyrin

Salicylate-selective membrane electrode based on tin(IV)-tetraphenylporphyrin

Voltammetric Investigation and Determination of Mefloquine

Validationof chromatographic methods of analysis of drugs in biological samples

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