Gas-chromatographic determination of monoethanolamine and its salts of inorganic and organophosphorus acids present in combination

Stan'kov, I. N.; Yarova, V. A.; Sergeeva, A. A.; Potashova, I. V.; Tarasov, S. N.; Samofalova, N. N.

doi:10.1007/bf02757742

Cited by 2 publications

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“…The dilute solutions of TEA, MEA and pyridine were prepared from their stock solutions. The concentration of amine (TEA, pKa = 7.8, MEA , pKa = 9.5 and pyridine pKa = 5.21) in the solution was analyzed by acid base titrations or spectrophotometer determinations or HPLC or gas chromatography (FID) [25][26][27][28][29][30][31][32][33] depending on the concentrations. The FSSM experimental apparatus used to measure the permeability coefficient (P) (Figure 1).…”

Section: Reagents and Apparatusmentioning

confidence: 99%

Cation exchange chromatographic separation of amines through fiber supported solid membrane

Gaikwad¹

2011

Chem. Eng. Res. Bull.

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Abstract:The cation exchange chromatographic separation of pyridine, monoethanol amine (MEA) and triethanol amine (TEA) have been explored from source to receiving phase through a fiber supported solid membrane (FSSM). The FSSM were prepared by chemical modification of cellulose fibers with introducing the carboxylic acid ion exchanging groups. The experimental values explored were concentration of pyridine, MEA and TEA (10 −2 to 10 −6 M) in the source solution, HCl (0.01 to 0.20 M) in the receiving phase and stirring speed (50-130 rpm) of the bulk source and receiving phase. The efficiency of FSSM has been evaluated for the transport of pyridine, MEA and TEA from the source to receiving through membrane phase. The enrichment factors (EF) for pyridine, MEA and TEA from the dilute solutions such as 10 −6 M observed were 1.62, 2.26 and 1.7, respectively.

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Section: Reagents and Apparatusmentioning

confidence: 99%

Cation exchange chromatographic separation of amines through fiber supported solid membrane

Gaikwad¹

2011

Chem. Eng. Res. Bull.

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Analysis of Monoethanolamine by Derivatization with Marfey's Reagent and HPLC

Ngim

Zynger

Downey³

2007

Journal of Chromatographic Science

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A sensitive and selective method for determining the residual monoethanolamine in a developmental drug substance is developed and validated. Marfey's reagent, which is commonly used for the chiral analysis of amino acids, is reacted with the primary amine group of monoethanolamine and then analyzed by high-performance liquid chromatography-UV at 340 nm. Quantitation is performed by a standard addition method by preparing drug substance samples with added monoethanolamine ranging from 0.25-1.0 microg/mL (equivalent to 12.5-50 ppm with respect to the drug substance). The method performance is evaluated for linearity, specificity, detection and quantitation limits, accuracy, precision, and sample stability. The method is linear from 0.25-1.0 microg/mL with a coefficient of determination (r(2)) > 0.95. The accuracy and precision obtained is 105.5 +/- 4.8% (n = 3). The limits of detection and quantitation are 0.03 and 0.10 microg/mL, respectively. Instrument precision (% relative standard deviation of six injections of a derivatized 0.5 microg/mL monoethanolamine solution on two separate days) is >/= 2.0%. This method is suitable for the determination of monoethanolamine at the 25 ppm level in drug substance.

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Gas-chromatographic determination of monoethanolamine and its salts of inorganic and organophosphorus acids present in combination

Cited by 2 publications

References 1 publication

Cation exchange chromatographic separation of amines through fiber supported solid membrane

Cation exchange chromatographic separation of amines through fiber supported solid membrane

Analysis of Monoethanolamine by Derivatization with Marfey's Reagent and HPLC

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