Gas chromatographic determination of residual ethylene oxide by head space analysis

Romano, S.; Renner, J. A.; Leitner, P. M.

doi:10.1021/ac60336a035

Cited by 39 publications

(9 citation statements)

References 10 publications

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“…Polymers known to carry over high amounts of ethylene oxide residues, the polyurethene and poly (vinyl chloride) , were analyzed by using the head-space gaschromatography method. 6 No residues were detected in these samples.…”

Section: Methodsmentioning

confidence: 84%

Tissue response to implanted polymers: The significance of sample shape

Matlaga¹,

Yasenchak²,

Salthouse³

1976

J. Biomed. Mater. Res.

258

104

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Studies were designed to demonstrate the need for standardization of shape of samples used as implants to evaluate histotoxicity of polymer materials. Six medical-grade polymers (polypropylene, polyethylene, polyurethane, silicone rubber, poly(vinyl chloride), and Teflon) were extruded as rods with circular-, triangular-, and pentagonal-shaped cross sections, and were implanted in rat gluteal muscles for 14 days. Evaluation of the tissue response was assessed by quantitating cellular lysosomal acid phosphatase enzyme activity by using microspectrophotometry. All triangular-shaped implants showed the highest enzyme activity and cellular response; pentagon shapes showed less, and circular rods showed the lowest activity. The results demonstrate the need for standard sample shape for valid comparative studies of tissue response to implanted polymers.

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Section: Methodsmentioning

confidence: 84%

Tissue response to implanted polymers: The significance of sample shape

Matlaga¹,

Yasenchak²,

Salthouse³

1976

J. Biomed. Mater. Res.

258

104

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“…A specific and sensitive method for the determination of ethylene oxide at the ppm level in sterilized material has been described (21). The method is simpler than others, morerapid (5o analyses per 8 hours), and moresensitive (limit 5o ppb).…”

Section: Ethylene Oxidementioning

confidence: 99%

Methyl Bromide and Ethylene Oxide as Fumigants

1978

Pure and Applied Chemistry

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“…Since many sterilized items are used in such a way that they contact sensitive human tissue, the residual ethylene oxide should be at a safe level since ethylene oxide is in itself toxic. EXPERIMENTAL Methods-Four methods of analysis were studied a gravimetric method (3) and three GC approaches (9)(10)(11)(12). Late in 1972, an ad hoc committee was formed within 279 made up of industrial, regulatory, and academic representatives.…”

Section: S J Romano' and J A Rennermentioning

confidence: 99%