Gas chromatographic determination of volatile sulfur compounds in the expired alveolar air in hepatopathic subjects

Kaji, Hiroshi; Hisamura, Masaya; Saito, Nariyoshi; Murao, Makoto

doi:10.1016/s0378-4347(00)81377-8

Cited by 35 publications

(12 citation statements)

References 5 publications

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“…Increased levels of these compounds have been reported, already many years ago, during liver function impairment [9][10][11]. DMS has been implicated as the primary cause of fetor hepaticus, the typical smell of the breath present in some liver patients [21,22].…”

Section: Discussionmentioning

confidence: 99%

“…Early studies identified methyl mercaptan (MM) and dimethyl sulphide (DMS) as present in the breath of cirrhotic patients in hepatic coma [9]. Subsequently, the research groups of Kaji [10,11] and Tangerman [12,13] used improved gas chromatographic methods to demonstrate that the levels of all of these sulphur containing molecules were elevated in the breath of patients with cirrhosis even outside liver coma. More recently, in a preliminary study of breath biomarkers in liver diseases, Sehnert and coworkers reported that isoprene, carbonyl sulphide and carbonyl disulphide concentrations were significant different from the values in normal subjects [14].…”

Section: Introductionmentioning

confidence: 99%

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Breath biomarkers of liver cirrhosis

Dadamio

Velde

Laleman

et al. 2012

Journal of Chromatography B

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The diagnosis of asymptomatic cirrhosis in patients with liver disease is of importance to start screening for complications in due time. Liver biopsy is neither sensitive nor practical enough to be used as a frequent follow-up test in patients with chronic liver disease. The volatile organic compounds present in exhaled breath offer the possibility of exploring internal physiologic and pathologic process in a non invasive way. This study examined whether a specific pattern of biomarkers can be found in breath samples of patients with cirrhosis. To this aim samples of alveolar breath from patients with cirrhosis and healthy volunteers were analyzed using gas chromatography-mass spectrometry. When linear discriminant analysis was used to search for a model(s)/pattern of compounds characteristic for liver cirrhosis, 24 models of 8 independent compounds could distinguish between the groups. The sensitivity and specificity (between 82% and 88%, and 96% and 100%, respectively) of the models suggest that a specific pattern of breath biomarkers can be found in patients with cirrhosis, which may allow detecting this complication of chronic liver disease in an early stage.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Breath biomarkers of liver cirrhosis

Dadamio

Velde

Laleman

et al. 2012

Journal of Chromatography B

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“…Traditionally, this foetor has been attributed to ketones and ammonia, however, more recent evidence suggests that DMS is the main odourant volatile, although ketones contribute to a lesser extent. [138][139][140][141] In vitro experimentation with DMS solutions was reported to produce an odour very similar to that produced in fetor hepaticus. 142 Mercaptans do not seem to directly cause hepatic encephalopathy, rather they just accumulate systemically.…”

Section: Foetor Hepaticusmentioning

confidence: 99%

Dimethylsulphidemia: the significance of dimethyl sulphide in extra-oral, blood borne halitosis

Harvey-Woodworth¹

2013

Br Dent J

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Halitosis is a symptom and not a diagnosis. Rather, the topic represents a spectrum of disorders, including intra-oral, otorhinolaryngological, metabolic, systemic, pulmonary, psychological and neurological conditions. Halitosis may be the third most common trigger for patients to seek dental care and can cause significant impact on patient quality of life. About 10% of all genuine halitosis cases are attributed to extra-oral processes. Some authorities have reported that the nasal cavity and the oropharynx are the most common sites of origin of extra-oral halitosis. However, recent evidence appears to suggest that blood borne halitosis may be the most common subtype of extra-oral halitosis. Tangerman and Winkel report that dimethyl sulphide was the main volatile implicated in extra-oral blood borne halitosis. They proposed a hitherto unknown metabolic condition by way of explanation for this finding, resulting in systemic presence of dimethyl sulphide in blood and alveolar breath. This paper reviews the knowledge base regarding the behaviour of dimethyl sulphide in physiological systems and those disorders in which blood borne halitosis secondary to dimethylsulphidemia is thought to have an aetiopathological role.

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“…Breath of healthy individuals contains trace amounts of VSCs. Their increased concentrations (low ppbs) are attributed to impaired liver functions [7][8][9][10][11][12], halitosis [13][14][15][16], organ rejection after lung transplantation [17], lung cancer [18], cystic fibrosis [19], or schizophrenia [20].…”

Section: Introductionmentioning

confidence: 99%