Gas chromatography-flame ionization detector for sweat based COVID-19 screening

Tungkijanansin, Nuttanee; Phusrisom, Sorachar; Chatdarong, Kaywalee; Torvorapanit, Pattama; Sirinara, Patthrarawalai; Nhujak, Thumnoon; Kulsing, Chadin

doi:10.1016/j.aca.2023.341878

Cited by 4 publications

(1 citation statement)

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“…It is worth noting that the accuracy in the vaccination screening is lower than that in COVID-19 screening (> 95 % accuracy). [46] This might involve the less significant changes in the contents of the characteristic highly volatile metabolites after the vaccination compared with the SARS-CoV-2 infection. This may also indicate the lower of impact of vaccination on the metabolism/catabolism.…”

Section: Gc-ims Analysis Of the Sweat Profile During The Vaccinationmentioning

confidence: 99%

Using Gas Chromatography‐Ion Mobility Spectrometry to Investigate Volatile Compound Profiles in Human Sweat during COVID‐19 Vaccination

Phusrisom,

Tungkijanansin,

Sirinara

et al. 2024

ChemistrySelect

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In this study, gas chromatography‐ion mobility spectrometry (GC‐IMS) was applied to analyze sweat volatile compounds for differentiation of population with COVID‐19 vaccination. This involves tentative identification of the compounds in 50 axillary swab samples obtained from 10 healthy female volunteers before or after nucleic acid‐based COVID‐19 vaccination at different periods up to two days. The samples were collected by using sterilized cotton rods with the sampling time of 15 min. The data were analyzed using partial least squares discriminant analysis (PLS‐DA) showing separation of the groups before and after the vaccination. Receiver operating characteristic (ROC) curves were then constructed for the detected peaks which revealed four possible marker peaks with the significantly downregulated or upregulated contents in the vaccinated samples. One of these markers was tentatively identified as methanol. With the optimum peak volume thresholds, the sensitivity, specificity and accuracy were up to 100 %, 85 % and 94 %, respectively. The marker peak volumes along the vaccination progresses were also monitored showing the significant decrease or increase of their contents within 6 h after the vaccination. The analysis approaches are expected to be useful to confirm stages of other vaccination.

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Section: Gc-ims Analysis Of the Sweat Profile During The Vaccinationmentioning

confidence: 99%