Gas chromatography/Fourier transform infrared/mass spectrometry using a mass selective detector

Cooper, John R.; Bowater, Ian C.; Wilkins, Charles L.

doi:10.1021/ac00126a046

Cited by 21 publications

(15 citation statements)

References 29 publications

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“…8 A number of publications successfully improved chromatographic, IR, and MS performance for a wide variety of samples using GC/FT-IR/MS instruments based on the LP configuration. [9][10][11][12][13][14][15][16][17][18][19][20] However, with typical detection limits ranging between 10 ng (polar compounds) and 50 ng (nonpolar compounds), even the most optimally configured GC/ FT-IR instruments based on the LP design were easily outperformed by GC/MS, which is why researchers explored condensing the GC effluent so it could be examined in a more concentrated solid deposit.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Orthogonal Drug Detection Using Fully Integrated Gas Chromatography with Fourier Transform Infrared Detection and Mass Spectrometric Detection

Lanzarotta¹,

Falconer²,

McCauley³

et al. 2016

Appl Spectrosc

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Analytes that co-elute and yield nearly identical electron ionization (EI) mass spectra, as well as analytes that yield non-specific EI fragmentation patterns, have been identified using fully integrated gas chromatography with direct deposit Fourier transform infrared detection and mass spectrometric detection (GC/FT-IR/MS). While the IR detector proved to be more selective for identifying analytes such as synthetic cannabinoids and weight loss drugs, it was limited by a relatively high detection limit of 8.4 parts per million (ppm) for non-targeted identification of sibutramine based on a single injection but was reduced to 840 parts per billion (ppb) for targeted identification of sibutramine by redepositing ten injections along the same track. The MS detector was less selective for identifying these analytes but yielded non-targeted and targeted detection limits of approximately 84 ppb and 8.4 ppb, respectively, which corresponded to a 100-fold advantage compared to the IR detector. Overall, the results of this study demonstrate that the advantages of each detector compensate for the limitations of the other, which allows a wider range of analytes and concentrations to be examined using a fully integrated GC/FT-IR/MS instrument compared to what can be examined using GC/IR or GC/MS independently. Not only does this approach reduce consumption of laboratory resources and time, it provides IR and MS information on the same sample, which is important for forensic analyses that require data from two or more orthogonal techniques to make an identification.

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Section: Introductionmentioning

confidence: 99%

Simultaneous Orthogonal Drug Detection Using Fully Integrated Gas Chromatography with Fourier Transform Infrared Detection and Mass Spectrometric Detection

Lanzarotta¹,

Falconer²,

McCauley³

et al. 2016

Appl Spectrosc

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“…Postsearch methods for combining discrete infrared Emd mass spectral library search results have been described (14)(15)(16).…”

Section: Literature Citedmentioning

confidence: 99%

Utilization of spectrometric information in linked gas chromatography-Fourier transform infrared spectroscopy-mass spectrometry

Cooper¹,

Wilkins²

1989

Anal. Chem.

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Fourier transform infrared (FTIR) and mass spectral (MS) data collected with linked GC-IR-MS systems are combined in a complementary fashion to Identify organic mixture components. Methodology to combine and compare Infrared and mass spectral Information generated by the linked system Is discussed. A 30-component mixture Is analyzed to demonstrate application of the system to mixture analysis. Analysis of a complex environmental soil sample further Illustrates the value of the methodology. Concurrent utilization of both types of spectral Information Increases the reliability of librarysearch-based Identifications. Thus, use of a 3304-member

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“…These meeting reports described the use of both a Finnigan ion trap (29) and a Hewlett-Packard MSD (30) for GC/ IR/MS. Publications describing re search using MSD mass spectrometers linked with FT-IR spectrometers from two different manufacturers (28,31) also appeared. In the first published report (31), Gurka analyzed six com plex environmental samples containing a total of 106 analytes.…”

Section: Lower Cost Gc/ir/msmentioning

confidence: 99%

“…Interest in the use of lower cost quadrupole instru ments has also recently involved some what more elaborate quadrupole mass spectrometers (32). Figure 3 shows typical reconstructed chromatograms that are obtainable with such a low-cost system, and Table II summarizes the analytical results obtained from the combined IR/MS li brary search and comparison software discussed above (28). These data, and the recent introduction of an integrat ed GC/IR/MS system based on a new dedicated infrared GC detector (IRD) (33) coupled with an MSD, suggest widespread acceptance of this analyti cal methodology may develop in the near future.…”

Section: Lower Cost Gc/ir/msmentioning

confidence: 99%

Linked Gas Chromatography Infrared Mass Spectrometry

Wilkins¹

1987

Anal. Chem.

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Gas chromatography/Fourier transform infrared/mass spectrometry using a mass selective detector

Cited by 21 publications

References 29 publications

Simultaneous Orthogonal Drug Detection Using Fully Integrated Gas Chromatography with Fourier Transform Infrared Detection and Mass Spectrometric Detection

Simultaneous Orthogonal Drug Detection Using Fully Integrated Gas Chromatography with Fourier Transform Infrared Detection and Mass Spectrometric Detection

Utilization of spectrometric information in linked gas chromatography-Fourier transform infrared spectroscopy-mass spectrometry

Linked Gas Chromatography Infrared Mass Spectrometry

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