Gas chromatography/mass spectrometric analysis of methyl esters of <i>N,N</i>‐dialkylaminoethane‐2‐sulfonic acids for verification of the Chemical Weapons Convention

Pardasani, Deepak; Gupta, Atul; Palit, Meehir; Shakya, Purushottam; Kanaujia, Pankaj K.; Sekhar, K.; Dubey, D. K.

doi:10.1002/rcm.2165

Cited by 14 publications

(15 citation statements)

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“…All compounds studied, 1 – 10 , were prepared by treating the corresponding N,N ‐dialkylaminoethyl‐2‐chloride with sodium bisulfite, following a known procedure 26. Formation of the compounds 1 – 10 in the reaction was confirmed by their GC/MS analyses after direct evaporation and methylation of the reaction mixture and matching their EI spectra with the reported spectra 26. The reaction products were not purified because the experiments were only performed at low concentrations (400 µM maximum) of N,N ‐dialkylaminoethyl‐2‐chloride.…”

Section: Methodsmentioning

confidence: 99%

“…N,N ‐Dialkylaminoethane‐2‐thiols are degradation products of VX‐type compounds, but they are also precursors in the synthesis of those compounds. Oxidation of N,N ‐dialkylaminoethane‐2‐thiols, for example, by detoxification of VX with bleach, produces N,N ‐dialkylaminoethane‐2‐sulphonic acids 25, 26. Therefore, N,N ‐dialkylaminoethane‐2‐sulphonic acids can be considered as markers for VX‐type compounds as well as for N,N ‐dialkylaminoethane‐2‐thiols in environmental samples.…”

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confidence: 99%

“…Recently, Pardasani et al . reported GC/EI‐MS data for the methyl esters of N,N ‐dialkylaminoethyl‐2‐sulphonic acids 26. Although it is easy to identify the methyl esters of N,N ‐dialkylaminoethyl‐2‐sulphonic acids from published EI data, the methylation step is crucial in this process.…”

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Electrospray ionization mass spectral studies of N,N‐dialkylaminoethane‐2‐sulphonic acids

Lakshmi

Prabhakar

Murty

et al. 2007

Rapid Comm Mass Spectrometry

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Oxidative reactions of VX type compounds and N,N-dialkylaminoethane-2-thiols that are precursors for VX compounds produce N,N-dialkylaminoethane-2-sulphonic acids, N(R(1))(R(2))-CH(2)-CH(2)SO(3)H (where R(1) and R(2) = methyl, ethyl, n-propyl and isopropyl, 1-10), as the degradation products, and these degradation products are considered as markers for the detection of chemicals listed in the schedules of Chemical Weapons Convention (CWC) chemicals. Off-site detection of such degradation products in aqueous samples is an important task in the verification of CWC-related chemicals. Here we report a simple method involving the direct analysis of aqueous samples using positive and/or negative ion electrospray ionization (ESI) for the screening, detection and identification of N,N-dialkylaminoethane-2-sulphonic acids, avoiding sample preparation and chromatographic steps. The positive ion ESI mass spectra of all the compounds result in abundant [M+Na](+) ions, and the negative ion spectra show abundant [M-H](-) ions to confirm their molecular weight. The collision-induced dissociation spectra of [M+Na](+) and [M-H](-) give characteristic product ions by which it is easy to detect and identify all the studied N,N-dialkylaminoethane-2-sulphonic acids including those of isomeric compounds. The method is successfully applied to detect the spiked chemical, N,N-diisopropylaminoethane-2-sulphonic acid, present in a water sample received in a proficiency test.

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Section: Methodsmentioning

confidence: 99%

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Electrospray ionization mass spectral studies of N,N‐dialkylaminoethane‐2‐sulphonic acids

Lakshmi

Prabhakar

Murty

et al. 2007

Rapid Comm Mass Spectrometry

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“…48 Additionally the methyl esters of N,N-dialkylaminoethane-2-sulfonic acids, R 2 NCH 2 CH 2 S(O) 2 OCH 3 , were analyzed by GC-EI mass spectroscopy. 49 Rapid determination of pesticide residues in Chinese materia medica using QuEChERS sample preparation followed by gas chromatographymass spectrometry. 50 In a minipig model, plasma was used in studying (iPrO(P=O)Me-(OH)) and cyclohexyl-O(P=O)Me(OH).…”

Section: Mass Spectrometricmentioning

confidence: 99%

Spectroscopic Methods for the Detection of Organophosphate Pesticides – A Preview

Kumar¹,

Upadhay²,

Wasit³

et al. 2013

Curr World Environ

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Organophosphate pesticides are the ester forms of phosphoric acid usually considered as secure for agriculture uses due to their relatively fast degradation rates. Organophosphorus pesticides have been extensively used in the area of agriculture to manage insect or pests of a number of economically important crops. Organophosphate pesticides are well-known as the inhibitor of acetylcholinesterase activity, not in insects only, but can also affect the nervous system of other organisms as well as humans. Organophosphorus pesticides are not restricted to anticholinesterase action, but comprise genotoxicity and teratogenicity including other environmental and ecological adverse impact. Such severe health and ecological consequences signify a requirement for a better understanding of the fate of organophosphates in the environment. By kept all these things in mind we have written a review on organophosphorus pesticides. In this review we have previewed the different methods of spectroscopic methods of detection including UV-visible, X-ray, Mass analysis, NMR, electrochemical analysis (sensor based) and FTIR. Among all these mass and electrochemical studies were flourished till date and considered as advanced techniques for the analysis of other pesticides also.

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“…[123][124][125][126][127][128][129][130][131][132][133] The Vertox Laboratory, Defense Research and Development Establishment, Gwalior, is another laboratory in India formally designated for the off-site analysis of chemicals prohibited under the CWC. [134][135][136][137][138][139][140][141][142][143] Work by Dubey and colleagues within this laboratory is devoted to developing novel extraction, derivatization and analytical methods for the analysis of scheduled chemicals, related degradation products and their derivatives in various matrices. Mass spectrometry is used extensively in this work and data on scheduled chemicals and their derivatives, not available in the literature or in the commercial libraries, are continuously generated for inclusion in the OPCW library.…”

Section: Introductionmentioning

confidence: 99%

Mass Spectrometry in India

Vairamani

Prabhakar

2012

Eur J Mass Spectrom (Chichester)

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All rights reserved EUROPEAN JOURNAL OF MASS SPECTROMETRY This review highlights the research in mass spectrometry carried out all over India, with a focus on the last two decades. There has been a phenomenal increase in the use of mass spectrometers in India during the last decade following the introduction, at the beginning of the 21st century, of rugged electrospray ionization sources for the commercially available instruments, with applications such as pharmacokinetics and bio-equivalence drug studies, pesticide residue analysis and proteomics. There have been more papers published in these areas than could be fully covered in this article. This review covers mostly research in mass spectrometry carried out continuously in institutions where advanced facilities for mass spectrometry are functional. Researchers in India, with some notable exceptions, have always used and still use commercial mass spectrometers in their various areas of research, rather than develop their unique instruments. The review is divided into three parts: organic, elemental (or atomic) and biological mass spectrometry. Organic mass spectrometry Organic and bio-organic chemistry Research in organic mass spectrometry in the early years was mainly focused on the study of mass spectral fragmentation of different classes of new compounds,and was initiated in the 1960s by the late Das and his colleagues from the National Chemical Laboratory (NCL), Pune. The first double-focusing mass spectrometer (CEC-110 B) was installed at NCL for high-resolution mass measurements. The compounds studied by Das and his colleagues included aromatic amides, Benzophenanthridine derivatives, norses

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Gas chromatography/mass spectrometric analysis of methyl esters of N,N‐dialkylaminoethane‐2‐sulfonic acids for verification of the Chemical Weapons Convention

Cited by 14 publications

References 20 publications

Electrospray ionization mass spectral studies of N,N‐dialkylaminoethane‐2‐sulphonic acids

Electrospray ionization mass spectral studies of N,N‐dialkylaminoethane‐2‐sulphonic acids

Spectroscopic Methods for the Detection of Organophosphate Pesticides – A Preview

Mass Spectrometry in India

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