Gas chromatography–mass spectrometric assay for propofol in cerebrospinal fluid of traumatic brain patients

Peeters, Mariska Y. M.; Kuiper, Hiltjo; Greijdanus, Ben; Naalt, Joukje van der; Knibbe, Catherijne; Uges, Donald

doi:10.1016/j.jchromb.2007.01.001

Cited by 10 publications

(2 citation statements)

References 19 publications

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“…To date, many studies have been conducted for the determination of PRO in biological fluids such as blood and urine. These studies include analytical methodologies such as spectrophotometric 5 , high-performance liquid chromatography (HPLC), [6][7][8][9] gas chromatography-mass spectrometry (GC-MS), 10,11 liquid chromatography-mass spectrometry (LC-MS), [12][13][14][15][16][17][18][19] and capillary electrophoresis. 20 However, there are a limited number of studies on the electrochemical analysis of PRO in the scientific literature.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric quantification of the anesthetic drug propofol (2,6-diisopropylphenol) in the pharmaceutical formulations on a boron-doped diamond electrode

et al. 2021

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In this paper, the detailed electrochemistry of propofol (PRO) which is one of the intravenous agents commonly used for sedative-hypnotic purposes was examined. In cyclic voltammetry, the agent showed one irreversible and diffusion?controlled oxidation peak, resulting in the formation of a couple with a reduction and re-oxidation wave at less positive potentials. The effect of electrode pretreatment procedures on the electrochemical response of PRO was investigated by using square wave voltammetry (SWV) and the optimum procedure was used to improve the signal response in subsequent studies. Quantification of PRO was done based on the first oxidation peak using SWV. After optimization of all variables, the linear working range of PRO was found to be between 2.5 ?g mL-1 (1.4?10-5 mol L-1) and 160.0 ?g mL-1 (1.1?10-3 mol L-1, n=15) with a detection limit 0.71 ?g mL-1 (3.9?10-6 mol L-1). No noteworthy interference effect was detected. Also, the developed method was used for quantification of PRO in pharmaceutical sample.

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Section: Introductionmentioning

confidence: 99%

Voltammetric quantification of the anesthetic drug propofol (2,6-diisopropylphenol) in the pharmaceutical formulations on a boron-doped diamond electrode

et al. 2021

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“…The United States Pharmacopeia (USP) suggested gas chromatography coupled with flame‐ionization detector while a high performance liquid chromatography (HPLC) method was recommended in the British Pharmacopoeia (BP) for its analysis . Several methods have been reported in the literature for PPF determination: sequential injection analysis, electrochemical methods, HPLC and gas chromatography . Cisatracurium besylate (CAC; Figure b ) is a competitive acetylcholine antagonist that binds to nicotinic receptors at the neuromuscular junction .…”

Section: Introductionmentioning

confidence: 99%

First derivative synchronous spectrofluorimetric method for the simultaneous determination of propofol and cisatracurium besylate in biological fluids

et al. 2019

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Propofol and cisatracurium besylate have been simultaneously determined using a highly sensitive first derivative synchronous spectrofluorometric method. The method is based on measuring first derivative synchronous spectrofluorimetric amplitude at Δλ = 40 nm with a scanning rate of 600 nm/min. The different experimental parameters affecting the fluorescence intensity of the two drugs were carefully studied and optimized. The amplitude–concentration plots were rectilinear over the range 40.0–400.0 ng/mL and 20.0–280.0 ng/mL for propofol and cisatracurium, respectively with lower detection limits of 4.0 and 2.35 ng/mL and quantification limits of 12.1 and 7.1 ng/mL for propofol and cisatracurium, respectively. The proposed method was successfully applied for the determination of the two compounds in synthetic mixtures and in commercial ampoules. The high sensitivity attained using the proposed method allowed the simultaneous determination of both drugs in spiked plasma samples. The mean % recoveries in spiked human plasma (n = 3) were 96.53 ± 0.90 and 96.20 ± 1.64 for each of propofol and cisatracurium, respectively. The method was validated in compliance with International Council of Harmonization (ICH) Guidelines.

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P, Sanz L. Snake venomics. Strategy and applications. J Mass Spectrom 2007; 42: 1405. He MY, Chen H. Current mass spectrometry of synthetic polymer. Curr Org Chem 2007; 11: 909. Helmke SM, Duncan MW. Measurement of the NO metabolites, nitrite and nitrate, in human biological fluids by GC-MS. J Chromatogr B 2007; 851: 83. Herrmann AM, Ritz K, Nunan N, Clode PL, Pett-Ridge J, Kilburn MR, Murphy DV, O'Donnell AG, Stockdale EA. Nano-scale secondary ion mass spectrometry -A new analytical tool in biogeochemistry and soil ecology: A review article. Soil Biol Biochem 2007; 39: 1835. Luque-Garcia JL, Neubert TA. Sample preparation for serum/plasma profiling and biomarker identification by mass spectrometry. J Chromatogr A 2007; 1153: 259. Nelson BC. The expanding role of mass spectrometry in folate research. Curr Anal Chem 2007; 3: 219. Portier S, Bremier S, Walker CT. Secondary ion mass spectrometry of irradiated nuclear fuel and cladding: An overview. Int J Mass Spectrom 2007; 263: 113. Vogl J. Characterization of reference materials by isotope dilution mass spectrometry. J Anal Atom Spectrom 2007; 22: 475. Wiechert W, Schweissgut O, Takanaga H, Frommer WB. Fluxomics: Mass spectrometry versus quantitative imaging. Curr Opin Plant Biol 2007; 10: 323. Williamson LN, Bartlett MG. Quantitative liquid chromatography/time-offlight mass spectrometry. Biomed Chromatogr 2007; 21: 567. Wyttenbach T, Bowers MT. Intermolecular interactions in biomolecular systems examined by mass spectrometry. Annu Rev Phys Chem 2007; 58: 511. 2 INSTRUMENTAL TECHNIQUES & METHODS Alvarez PA, Ramaswamy HS, Ismail AA. Effect of high-pressure treatment on the electrospray ionization mass spectrometry (ESI-MS) profiles of whey proteins. Int Dairy J 2007; 17: 881. Andreev VP, Li LY, Cao L, Gu Y, Rejtar T, Wu SL, Karger BL. A new algorithm using cross-assignment for label-free quantitation with LC-LTQ-FT MS. J Proteome Res 2007; 6: 2186. Bereman MS, Muddiman DC. Detection of attomole amounts of analyte by desorption electrospray ionization mass spectrometry (DESI-MS) determined using fluorescence spectroscopy. J Am Soc Mass Spectrom 2007; 18: 1093. Borges CR. Concept for facilitating analyst-mediated interpretation of qualitative chromatographic-mass spectral data: An alternative to manual examination of extracted ion chromatograms. Anal Chem 2007; 79: 4805. Carreira RJ, Cordeiro FM, Moro AJ, Rivas MG, Rial-Otero R, Gaspar EM, Moura I, Capelo JL. New findings for in-gel digestion accelerated by high-intensity focused ultrasound for protein identification by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. J Chromatogr A 2007; 1153: 291. Chambers E, Wagrowski-Diehl DM, Lu ZL, Mazzeo JR. Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analyses. J Chromatogr B 2007; 852: 22. Charvat A, Abel B. How to make big molecules fly out of liquid water: Applications, features and physics of laser assisted liquid phase dispersion mass spectrometry. Phys Chem Chem Phys 2007; 9: 3335. Codrea MC, Jimenez CR, Heri...

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Gas chromatography–mass spectrometric assay for propofol in cerebrospinal fluid of traumatic brain patients

Cited by 10 publications

References 19 publications

Voltammetric quantification of the anesthetic drug propofol (2,6-diisopropylphenol) in the pharmaceutical formulations on a boron-doped diamond electrode

Voltammetric quantification of the anesthetic drug propofol (2,6-diisopropylphenol) in the pharmaceutical formulations on a boron-doped diamond electrode

First derivative synchronous spectrofluorimetric method for the simultaneous determination of propofol and cisatracurium besylate in biological fluids

Current literature in mass spectrometry

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