Gas chromatography/mass spectrometry analysis of the six‐ring regioisomeric dimethoxybenzyl‐N‐methylpiperazines (DMBMPs)

Abstract

The six regioisomeric dimethoxybenzyl-N-methylpiperazines yield equivalent fragment ions and deuterium labeling confirmed the elemental composition of the characteristic fragments in their mass spectra. Mixtures of the dimethoxybenzyl-N-methylpiperazines were successfully resolved via capillary gas chromatography using a relatively polar stationary phase and temperature-programming conditions. Copyright © 2013 John Wiley & Sons, Ltd.

Design, Synthesis and Biological Evaluation of Potent Antioxidant 1‐(2,5‐Dimethoxybenzyl)‐4‐arylpiperazines and N‐Azolyl Substituted 2‐(4‐Arylpiperazin‐1‐yl)

“…In a final step, the reaction of intermediate 32 with a series of commercial piperazines afforded products 1–10 , in a moderate to good yield (Scheme ). With the exception of products 1 and 10 , all molecules 1–29 from this work are described for the first time (Figure ) and they were all isolated as pure samples having analytical and spectroscopic data in good agreement with their structures (see Supporting Information ).…”

An overview of recent developments in the analytical detection of new psychoactive substances (NPSs)

“…117 Dickson et al 118 reported that BZP, 3′-TFMPP and MCPP are present in ecstasy tablets since the former, in some nations, is a legal alternative to MDMA. 118 A wide array of analytical approaches have been reported by many different authors such as LC-MS, 24,119 capillary electrophoresis, 120 HPLC-fluorescence, 121 LC with diode array, 122,123 GC-MS [124][125][126] and chemiluminescence. 118 In 36% of the sample, drugs other than MDMA were found to be present; BZP, 3-TFMPP and MCPP were detected in 15%, 7% and 1% of the samples respectively.…”

“…118 In 36% of the sample, drugs other than MDMA were found to be present; BZP, 3-TFMPP and MCPP were detected in 15%, 7% and 1% of the samples respectively. 118 A wide array of analytical approaches have been reported by many different authors such as LC-MS, 24,119 capillary electrophoresis, 120 HPLC-fluorescence, 121 LC with diode array, 122,123 GC-MS [124][125][126] and chemiluminescence. 127 Arbo and coworkers 128 provided a thorough overview of piperazine compounds as drugs of abuse with the full range of analytical techniques and matrices applied, readers are directed to this paper.…”