Gas Chromatography/Matrix Isolation/Infrared Spectroscopy: An Evaluation of the Performance Potential

Simultaneous Orthogonal Drug Detection Using Fully Integrated Gas Chromatography with Fourier Transform Infrared Detection and Mass Spectrometric Detection

“…Matrix isolation (MI) [21][22][23] consists of mixing effluent from a GC column with argon and cryogenically freezing it to a spot as small as 250 mm  250 mm on an IR reflecting rotating disk cooled with liquid helium. After the chromatographic run is completed, an IR spectrum is collected in reflection/absorption mode on each spot along the spiral track.…”

Applications of multidimensional-gas chromatography-mass spectrometry and gas chromatography-Fourier transform infrared-mass spectrometry

“…The use of MI-FTIR as a GC detector was first described in 1979 (69,70), with the first commercially available instrument introduced in the mid-1980s. In this technique, argon gas (typically) is mixed with the carrier gas, and the analyte is deposited in an argon matrix onto a rotating gold-coated cryogenic disk that is maintained at about 12K.…”

“…Direct deposition FT-IR detection is very similar to matrix isolation in that the GC effluent is trapped onto a cold surface (70)(71)(72)(73)(74). The two main differences, however, are the absence of a matrix gas and, in the commercial version, the surface is a ZnSe window, which allows transmission spectra to be collected.…”

Pesticide Determination by GC/FT–IR

“…In another method of GC/FT-IR analysis, matrix isolation GC/FT-IR (MI GC/FT-IR), the gaseous eluent from the gas Chromatograph is cryogenically frozen out in an inert matrix on a metal drum and subsequently analyzed by micro FT-IR reflection techniques (Bourne et al, 1979). Most pesticide residue chemists will insist that picogram or parts per trillion (ppt) dectection is necessary for residue analysis.…”