2024
DOI: 10.1002/chem.202400516
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Gas Evolution as a Tool to Study Reaction Kinetics Under Biomimetic Conditions

Eva J. Meeus,
Petrus C. M. Laan,
Rens Ham
et al.

Abstract: The field of bioorthogonal chemistry is rapidly growing, presenting successful applications of organic and transition metal catalysed reactions in cells and living systems (in vivo). The development of such reactions typically proceeds through many iterative steps focused on biocompatibility and fast reaction kinetics to ensure product formation. However, obtaining kinetic data, even under simulated biological (biomimetic) conditions, remains a challenge due to substantial concentrations of salts and biomolecu… Show more

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