Gas injection approach for synthesis of hydroxyapatite nanorods via hydrothermal method

Nosrati, Hassan; Sarraf-Mamoory, Rasoul; Le, Dang Quang Svend; Bünger, Cody; Emameh, Reza Zolfaghari; Dabir, Fatemeh

doi:10.1016/j.matchar.2019.110071

Cited by 39 publications

(63 citation statements)

References 58 publications

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“…It can be concluded that the leached obtained showed no significant toxicity to the osteoblasts culture (over a 7-day period). The only difference with the previously published work [52] is the morphology of the cells that are globular. The presence of GNR, which has become hydrophobic by the loss of its surface agents, may have caused this change.…”

Section: Resultscontrasting

confidence: 56%

“…Figure 2 shows the XRD pattern of GNR-HA powders, HA crystal planes, and FESEM images of GNR-HA powders. According to the XRD pattern of the synthesized powders (Figure 2a), full conformity is achieved between the reference standard of pure HA (JCPDS 09-0432) and the peaks obtained [52]. Accordingly, the HA has a high purity hexagonal structure.…”

Section: High-resolution Transmission Electron Microscopymentioning

confidence: 58%

“…As previously reported [52], sintering of the powders was performed at 950 • C. The biocompatibility assays were performed exactly similar to the previous report [52]. The Archimedes method was used to calculate the relative density of sintered samples (ASTM C373-88).…”

Section: Evaluation Of the Sinteredsamplesmentioning

confidence: 99%

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Synthesis of Graphene Nanoribbons–Hydroxyapatite Nanocomposite Applicable in Biomedicine and Theranostics

Nosrati

Sarraf-Mamoory

Ahmadi

et al. 2020

JNT

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In order to investigate the effect of graphene nanoribbons on the final properties of hydroxyapatite-based nanocomposites, a solvothermal method was used at 180 °C and 5 h for the synthesis of graphene nanoribbons–hydroxyapatite nanopowders by employing hydrogen gas injection. Calcium nitrate tetrahydrate and diammonium hydrogenphosphate were used as calcium and phosphate precursors, respectively. To synthesize the powders, a solvent containing diethylene glycol, anhydrous ethanol, dimethylformamide, and water was used. Graphene oxide nanoribbons were synthesized by chemical unzipping of carbon nanotubes under oxidative conditions. The synthesized powders were consolidated by spark plasma sintering methodat 950 °C and a pressure of 50 MPa. The powders and sintered samples were then evaluated using X-ray diffraction, Raman spectroscopy, high-resolution transmission electron microscopy, Vickers microindentation techniques, and biocompatibility assay. The findings of this study showed that the final powders synthesized by the solvothermal method had calcium to phosphate ratio of about 1.67. By adding a small amount of graphene nanoribbon (0.5%W), elastic modulus and hardness of hydroxyapatite increased dramatically. In biological experiments, the difference of hydroxyapatite effect in comparison with the nanocomposite was not significant. The findings of this study showed that graphene nanoribbons have a positive effect on the properties of hydroxyapatite, and these findings would be useful for the medical and theranostic application of this type of nanocomposites.

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Section: Resultscontrasting

confidence: 56%

Section: High-resolution Transmission Electron Microscopymentioning

confidence: 58%

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Synthesis of Graphene Nanoribbons–Hydroxyapatite Nanocomposite Applicable in Biomedicine and Theranostics

Nosrati

Sarraf-Mamoory

Ahmadi

et al. 2020

JNT

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“…But at high loading rates, the energy was spent on elastic deformation, plastic deformation, nucleation and growth of created cracks. The hardness and elastic modulus of this composite (hydrothermal process in 5 h) at 1 N loading was equal to the properties of pure HA under similar conditions and the hydrothermal process in 10 h [37]. This indicated that the presence of rGO sheets had a great influence on the mechanical properties because of the lower crystallinity of the powders at low synthesis times.…”

Section: Preparation Of Ha-rgo Nanocompositementioning

confidence: 66%

“…Elastic modulus and hardness were calculated from the load-displacement curves (figure 2(c)) using Oliver-Pharr method [36]. Table 1 shows the specifications for the analytical methods and devices [34,37]. A diamond nail was used to evaluate the nanocomposite's resistance to scratch.…”

Section: Preparation Of Ha-rgo Nanocompositementioning

confidence: 99%

Investigating the mechanical behavior of hydroxyapatite-reduced graphene oxide nanocomposite under different loading rates

Nosrati

Sarraf-Mamoory

et al. 2020

Nano Ex.

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In this study, the hydroxyapatite (HA)-reduced graphene oxide (rGO) nanocomposite was investigated for its mechanical properties. The nanocomposite used in this study was made in two stages. The HA-rGO powders were first synthesized by hydrogen gas injected hydrothermal method, and then consolidated by spark plasma sintering. HA-rGO nanocomposite was subjected to Vickers indentation experiments with different loading rates. Various analyzes have been used in this study, including x-rays diffraction, field emission scanning electron microscopy, high-resolution transmission electron microscopy, fast fourier transform, and inverse fast fourier transform. The findings of this study showed that the HA in this nanocomposite was reinforced with rGO sheets coated with HA. As the loading rate increased, the slope of the curves in the elastic region was increased, indicating that the elastic modulus was increased. Also, the contact depth at higher loading rates was increased. Plastic deformation was higher at higher loading rates and the hardness had increased. As the loading rate increased from 300 mN to 1 N, the hardness and elastic modulus increased with more slope than when the loading rate changed from 1 N to 2 N. The presence of rGO sheets had partially controlled the HA brittleness.

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In Vitro Osteogenic Response to Copper‐Doped Eggshell‐Derived Hyroxyapatite With Macrophage Supplements

Patil,

Patel,

Lim

2024

J Biomedical Materials Res

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The high bioactivity and biocompatibility of hydroxyapatite (HAP) make it a useful bone graft material for bone tissue engineering. However, the development superior osteoconductive and osteoinductive materials for bone regeneration remains a challenge. To overcome these constraints, Cu‐doped hydroxyapatite (HAP(Cu)) from waste eggshells has been produced for bone tissue engineering. The materials produced were characterized using Fourier transform infrared spectroscopy, x‐ray diffraction, and photoelectron spectroscopy. The scanning microscopy images revealed that the developed HAP was a rod‐like crystalline structure with a typical 80–150 nm diameter. Energy‐dispersive x‐ray spectroscopy showed that the generated HAP was mostly composed of calcium, oxygen, and phosphorus. The Ca/P molar ratios in eggshell‐derived and copper‐doped HAP were 1.61 and 1.67, respectively, similar to the commercially available HAP ratio (1.67). The WST‐8 assay was used to assess the biocompatibility of HAPs with hBMSCs. HAP(Cu) in the media significantly altered the cytotoxicity of biocompatible HAP(Cu). The osteogenic potential of HAP(Cu) was demonstrated by greater mineralization than that of pure HAP or the control. HAP(Cu) showed higher osteogenic gene expression than pure HAP and the control, indicating its stronger osteogenic potential. Furthermore, we assessed the effects of sample‐treated macrophage‐derived conditioned medium (CM) on hBMSCs' osteogenesis. CM‐treated HAP(Cu) demonstrated a significantly higher osteogenic potential vis‐à‐vis pure HAP(Cu). These findings revealed that HAP(Cu) with CM significantly improved osteogenesis in hBMSCs and can be explored as a bone graft in bone tissue engineering.

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Gas injection approach for synthesis of hydroxyapatite nanorods via hydrothermal method

Cited by 39 publications

References 58 publications

Synthesis of Graphene Nanoribbons–Hydroxyapatite Nanocomposite Applicable in Biomedicine and Theranostics

Synthesis of Graphene Nanoribbons–Hydroxyapatite Nanocomposite Applicable in Biomedicine and Theranostics

Investigating the mechanical behavior of hydroxyapatite-reduced graphene oxide nanocomposite under different loading rates

In Vitro Osteogenic Response to Copper‐Doped Eggshell‐Derived Hyroxyapatite With Macrophage Supplements

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