Abstract-The analysis of the influence by the impeller type in a stirred hybrid airlift bioreactor was performed in relation to the gas holdup, and mass transfer. The comparative study was performed using three-bladed marine and Lightnin A310 (axial flow impellers), and six-bladed Rusthon turbine and six-bladed Smith turbine (radial flow impellers). The experiments were conducted using distilled water at 25 0 C and a constant rotation velocity of 800 rpm, as well as in the absence of agitation (airlift mode); the superficial gas velocity varied from 0.0157 to 0.0262 ms -1 . The gas holdup and oxygen transfer coefficient was higher with the use of radial impellers; however, the mechanical power input required while using radial impellers is 730-1400% higher than with axial impellers.Index Terms-Axial Impeller, hydrodynamics, mass transfer, radial impeller, stirred airlift bioreactor.