Gas-phase study of adduct and exchange complexation reactions between two and tridimensional macrocyclic ligands using ion mobility spectrometry and mass spectrometry

Alizadeh, Naader; Parchami, Razieh; Pauw, Edwin De; Tabrizchi, Mahmoud

doi:10.1016/j.ijms.2020.116512

Cited by 2 publications

(3 citation statements)

References 39 publications

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“…However, IMS-MS is still highly underexploited in the field of synthetic cages or macrocycles and their host : guest chemistry. [34][35][36][37][38][39][40][41][42][43] Herein, a combination of MS methods (single-stage, collision induced dissociation (CID) and IMS-MS experiments), fluorescence spectroscopy, NMR as well as molecular modelling of the supramolecular complexes of the Cy cages and the peptide EYE is reported to decipher the intimate details of the binding event, both in aqueous solution and in the gas-phase.…”

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confidence: 99%

Pseudopeptidic host adaptation in peptide recognition unveiled by ion mobility mass spectrometry

Tapia

Pérez

Solà

et al. 2022

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mentioning

confidence: 99%

Pseudopeptidic host adaptation in peptide recognition unveiled by ion mobility mass spectrometry

Tapia

Pérez

Solà

et al. 2022

Analyst

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“…To avoid complex reactions between the reactant ions and the samples, only compounds that generated one type of product ions were first selected. Examples of these are crown ethers and amines that generate a stable complex ion of M·NH 4 + or MH + , with no dimer formation or fragmentation . The time evolution of the complex ion mobility spectra containing more than one product ion is the subject of our next study.…”

Section: Methodsmentioning

confidence: 99%

“…Examples of these are crown ethers and amines that generate a stable complex ion of M•NH 4 + or MH + , with no dimer formation or fragmentation. 28 The time evolution of the complex ion mobility spectra containing more than one product ion is the subject of our next study.…”

Section: Introducing the Samples Generating The Inputmentioning

confidence: 99%

Dynamic Response of Ion Mobility Spectrometry

Tabrizchi

Abadi

Parchami

et al. 2022

J. Am. Soc. Mass Spectrom.

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Ion mobility spectrometers (IMS) are widely used in the security industry as well as in analytical measurements. Nevertheless, the IMS input is dynamic in nature because the sampling input can vary over time. Similar to most instruments, IMS is unable to respond immediately to variations in the input sample. Therefore, the measurements are made under transient conditions, which may affect the results. This work investigates the dynamic response of an IMS to different inputs, including steps, pulsed, exponential, and Gaussian functions. A theoretical model was developed based on two phenomena: the accumulation or dilution of a sample in the ionization region and the adsorption or desorption inside the injection port. Both processes have a charging/discharging nature. Thus, a mathematical expression was derived that takes into account two RC circuits in series. Fitting the output signal of the experimental data to the expression obtained from the model gave reasonable time constants of 2–4 s and 15–20 s for the dilution and the desorption processes, respectively. The model performance was evaluated by comparing the output with the experimental results, which were in excellent correlation. IMS was also found to behave in a manner similar to a second-order instrument, in which the output is related to the input via a second-order differential equation. These results are applicable to GC-IMS and IMS-based detectors.

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Gas-phase study of adduct and exchange complexation reactions between two and tridimensional macrocyclic ligands using ion mobility spectrometry and mass spectrometry

Cited by 2 publications

References 39 publications

Pseudopeptidic host adaptation in peptide recognition unveiled by ion mobility mass spectrometry

Pseudopeptidic host adaptation in peptide recognition unveiled by ion mobility mass spectrometry

Dynamic Response of Ion Mobility Spectrometry

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