Understanding gas flow in depleted unconventional reservoirs is crucial but limited, particularly in organic-rich shale with ultrafine nanopores and high matrix compressibility. Here, we assess the apparent permeability (k app ) along perpendicular and parallel to bedding, as well as through fractures�using shale samples from three petroliferous basins in India. Our experiments simulate depleted reservoir conditions with varying mean pore pressures (P m ), using both sorbing (N 2 , CO 2 ) and nonsorbing (He, Ar) gases, and the results are compared to nanopore structures determined through low-pressure gas sorption and He-pycnometer. We further explored the gas fluid dynamic behavior, intrinsic permeability (k ∞ ), stress sensitivity, and effective stress coefficients and correlated between experimental variables and shale properties. We found that gas type and shale anisotropy significantly influence k app . He, exhibits the highest k app , followed by Ar, N 2 , and the lowest for CO 2 due to varying adsorption affinities. At lower effective stress (σ eff < 15 MPa), bedding parallel gas flow results in higher k app , while at higher stress, perpendicular flow increases permeability. Bedding perpendicular flow is matrix-dominated, while bedding parallel flow contains stress-sensitive microfractures serving as flow conduits. CO 2 in parallel bedding and fractured samples show a nonlinear relationship between slippage factor (b) and σ eff , indicating higher sensitivity compared to bedding perpendicular samples. Gas type exerts a stronger impact on b than σ eff . Notably, CO 2 with higher adsorption affinity, low k app , and enhanced penetration capacity in complex nanopores, emerges as a practical candidate for carbon storage and enhanced oil/gas recovery.