Gaseous air pollution and atopy

Charpin, D.; Pascal, Laurence; Birnbaum, J.; Armengaud, A.; Sambuc, Roland; Lanteaume, A.; Vervloët, D.

doi:10.1046/j.1365-2222.1999.00685.x

Cited by 36 publications

(25 citation statements)

References 17 publications

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“…We have recently reported an increase in the proportion of positive cutaneous IgE-mediated responses in 234 traffic wardens with a well defined occupational history of road traffic fume exposure in the city of Catania which has one of the highest levels of traffic intensity in Italy (60). In contrast, such differences were not observed in other studies (61,62). However these studies refer exclusively to gaseous air pollution and not to particulate pollutants; there is no experimental evidence that gaseous air pollutants are able to enhance IgE production or atopic sensitization.…”

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confidence: 72%

Adverse respiratory effects and allergic susceptibility in relation to particulate air pollution: flirting with disaster

Cacciola

Sarvà

Polosa

2002

Allergy

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The prevalence of allergic conditions such as asthma, rhinoconjunctivitis and atopic eczema/dermatitis has steadily increased in recent decades. Elicitation of an IgE-mediated allergic trait appears to be determined by the complex interplay of multiple genetic and environmental factors. However, although genetic factors in addition to allergen exposure are important, the observed rise in the prevalence of allergic conditions is likely to be ensuing from modifications occurring in the environment (1-3). The remarkable expansion in motor vehicle traffic and its associated emissions has paralleled the world-wide increase in the prevalence of respiratory tract conditions (4). Over the last 40 years the global vehicular fleet has expanded ten-fold and the number of vehicles are predicted to increase even further over the next 20-30 years (5). Estimates by the United Nations indicate that over 600 million people living in cities and towns world-wide are exposed to unhealthy and dangerous levels of motor vehicle generated air pollutants (6).Although the health effects of urban air pollution on the respiratory tract has been the focus of much research in recent times, it appears that less attention has been given to the potential role of pollutants emitted from motor vehicle exhausts in the elicitation of allergic conditions. Several laboratory based studies have demonstrated that particulate air pollutants emitted from motor vehicles can induce mucosal inflammation, enhance IgE responses, and heighten airway hyperresponsivenss which could provide an explanation for the increasing prevalence of respiratory symptoms and allergic diseases (7). The present article reviews our current understanding of the mechanisms by which pollutants such as diesel exhaust particles (DEP) enhance the underlying allergic inflammatory response, and the evidence that supports the causative link between particulate air pollution from motor vehicles and increasing allergic diseases. This article will comply with the recently revised nomenclature of allergic disorders proposed by an EAACI task force (8).Particulate air pollutants and respiratory symptoms: epidemiological evidence A number of epidemiological studies in several countries support the view that exposure to traffic-related pollutants is associated with a broad spectrum of adverse short-term respiratory effects in vulnerable individuals. Studies in Japan (9-11) have shown that people living close to main roads with heavy traffic suffered more respiratory symptoms and allergies than those living further away. Similar studies carried out in the UK (12) and in the Netherlands (13, 14) reported increased respiratory symptoms and reduced lung function in those children living in close proximity of roads with high traffic intensity, which positively correlated with the levels of particulate matter in the

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confidence: 72%

Adverse respiratory effects and allergic susceptibility in relation to particulate air pollution: flirting with disaster

Cacciola

Sarvà

Polosa

2002

Allergy

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“…Although mean levels of each pollutant (sulfur dioxide, nitrogen dioxide, and ozone) differed between towns, there was no correlation between the level of air pollution, the presence of atopy in children, and the level of dust mite allergen in the mattresses of sensitized children. Therefore, this study did not demonstrate an association between higher air pollution levels and atopic status, although a major limitation was that it only measured outdoor ambient air pollutant levels rather than personal exposure [18].…”

Section: Atopymentioning

confidence: 90%

“…For example, a study conducted in France that measured the air pollutants sulfur dioxide, nitrogen dioxide, and ozone over a 2-month period at various monitoring stations in a region known to have the highest level of air pollution in France found no association with sensitization [18]. In this study, parents of 2604 students were asked to answer a health questionnaire about their children, and all children who had not been previously skin tested or who were not undergoing desensitization (n = 2073) were skin prick tested to fi ve standardized allergen extracts.…”

Section: Atopymentioning

confidence: 99%

Air pollution and allergic disease

Kim

Bernstein

2009

Curr Allergy Asthma Rep

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Over the past several decades, there has been increased awareness of the health effects of air pollution and much debate regarding the role of global warming. The prevalence of asthma and allergic disease has risen in industrialized countries, and most epidemiologic studies focus on possible causalities between air pollution and these conditions. This review examines salient articles and summarizes findings important to the interaction between allergies and air pollution, specifically volatile organic compounds, global warming, particulate pollutants, atopic risk, indoor air pollution, and prenatal exposure. Further work is necessary to determine whether patients predisposed to developing allergic disease may be more susceptible to the health effects of air pollutants due to the direct interaction between IgE-mediated disease and air pollutants. Until we have more definitive answers, patient education about the importance of good indoor air quality in the home and workplace is essential. Health care providers and the general community should also support public policy designed to improve outdoor air quality by developing programs that provide incentives for industry to comply with controlling pollution emissions.

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“…Exposure to ambient air pollutants has been suggested to increase the risk of AR in children, but the evidence was still weak and inconclusive [6][7][8][9][10][11][12][13]. Some studies have suggested that exposure to outdoor air pollutants, especially for traffic-related pollutant, may increase the risk of allergic rhinitis in children [6][7][8].…”

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confidence: 99%

Effects of ambient air pollution on allergic rhinitis among preschool children in Changsha, China

Deng

et al. 2013

Chin. Sci. Bull.

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Gaseous air pollution and atopy

Abstract: The increase in photochemical air pollutants is unlikely to be a major determinant for the recent increase in the prevalence of atopy.

Cited by 36 publications

References 17 publications

Adverse respiratory effects and allergic susceptibility in relation to particulate air pollution: flirting with disaster

Adverse respiratory effects and allergic susceptibility in relation to particulate air pollution: flirting with disaster

Air pollution and allergic disease

Effects of ambient air pollution on allergic rhinitis among preschool children in Changsha, China

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