Gaseous Mediators in Temperature Regulation

Branco, Luiz G.S.; Soriano, Renato Nery; Steiner, Alexandre A.

doi:10.1002/cphy.c130053

Cited by 33 publications

(30 citation statements)

References 404 publications

(555 reference statements)

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“…Functional studies are needed to determine how NO acts in both adult female rhesus monkeys and ewes to influence GnRH neuronal activity and GnRH secretion. Additionally, nNOS neurons are involved in the control of other physiological processes besides reproduction, including temperature, thirst, fluid balance, stress, glucose homeostasis, food intake, and energy expenditure [45][46][47][48][49][50][51][52]. Thus, NO signaling could serve as an integrator to communicate these effects to GnRH neurons to influence reproduction.…”

Section: Discussionmentioning

confidence: 99%

Neuroanatomical Relationship of Neuronal Nitric Oxide Synthase to Gonadotropin-Releasing Hormone and Kisspeptin Neurons in Adult Female Sheep and Primates

Bedenbaugh¹,

McCosh²,

Lopez³

et al. 2018

Neuroendocrinology

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Background: Neuronal intermediates that communicate estrogen and progesterone feedback to gonadotropin-releasing hormone (GnRH) neurons are essential for modulating reproductive cyclicity. Individually, kisspeptin and nitric oxide (NO) influence GnRH secretion. However, it is possible these 2 neuronal intermediates interact with one another to affect reproductive cyclicity. Methods: We investigated the neuroanatomical relationship of one isoform of the enzyme that synthesizes NO, neuronal NO synthase (nNOS), to kisspeptin and GnRH in adult female rhesus monkeys and sheep using dual-label immunofluorescence. Additionally, we evaluated if the phase of the reproductive cycle would affect these relationships. Results: Overall, no effect of the stage of cycle was observed for any variable in this study. In the arcuate nucleus (ARC) of sheep, 98.8 ± 3.5% of kisspeptin neurons colocalized with nNOS, and kisspeptin close-contacts were observed onto nNOS neurons. In contrast to ewes, no colocalization was observed between kisspeptin and nNOS in the infundibular ARC of primates, but kisspeptin fibers were apposed to nNOS neurons. In the preoptic area of ewes, 15.0 ± 4.2% of GnRH neurons colocalized with nNOS. In primates, 38.8 ± 10.1% of GnRH neurons in the mediobasal hypothalamus colocalized with nNOS, and GnRH close-contacts were observed onto nNOS neurons in both sheep and primates. Conclusion: Although species differences were observed, this work establishes a neuroanatomical framework between nNOS and kisspeptin and nNOS and GnRH in adult female nonhuman primates and sheep.

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Section: Discussionmentioning

confidence: 99%

Neuroanatomical Relationship of Neuronal Nitric Oxide Synthase to Gonadotropin-Releasing Hormone and Kisspeptin Neurons in Adult Female Sheep and Primates

Bedenbaugh¹,

McCosh²,

Lopez³

et al. 2018

Neuroendocrinology

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“…There is, however, no evidence for a role of nitric oxide as a pyrogenic signal to the brain (Steiner et al 2004). Within the brain nitric oxide exerts antipyretic rather than pyrogenic effects (Branco et al 2014;Roth 2006). In parallel with this, but most likely independently regulated, prostaglandins and possibly nitric oxide initiate the synthesis of pro-inflammatory molecules in microglia and astrocytes that underlie many of the sickness behaviors described above, as well as other neurological effects (D'Mello et al 2013).…”

Section: Introductionmentioning

confidence: 93%

Fever and sickness behavior: Friend or foe?

Harden

Kent

Pittman

et al. 2015

Brain, Behavior, and Immunity

129

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“…Fever is a brain-driven regulated increase in deep body temperature (Tb) and a hallmark of the acute phase response of systemic inflammation [5,6]. This thermoregulatory response can be experimentally induced by administration of exogenous or endogenous pyrogens, and is the product of coordination of inflammatory mediators [5].…”

Section: Introductionmentioning

confidence: 99%

Effect of Physical Exercise on the Febrigenic Signaling is Modulated by Preoptic Hydrogen Sulfide Production

et al. 2017

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We tested the hypothesis that the neuromodulator hydrogen sulfide (H2S) in the preoptic area (POA) of the hypothalamus modulates the febrigenic signaling differently in sedentary and trained rats. Besides H2S production rate and protein expressions of H2S-related synthases cystathionine β-synthase (CBS), 3-mercaptopyruvate sulfurtransferase (3-MPST) and cystathionine γ-lyase (CSE) in the POA, we also measured deep body temperature (Tb), circulating plasma levels of cytokines and corticosterone in an animal model of systemic inflammation. Rats run on a treadmill before receiving an intraperitoneal injection of lipopolysaccharide (LPS, 100 μg/kg) or saline. The magnitude of changes of Tb during the LPS-induced fever was found to be similar between sedentary and trained rats. In sedentary rats, H2S production was not affected by LPS. Conversely, in trained rats LPS caused a sharp increase in H2S production rate that was accompanied by an increased CBS expression profile, whereas 3-MPST and CSE expressions were kept relatively constant. Sedentary rats showed a significant LPS-induced release of cytokines (IL-1β, IL-6, and TNF-α) which was virtually abolished in the trained animals. Correlation between POA H2S and IL-6 as well as TNF-α was observed. Corticosterone levels were augmented after LPS injection in both groups. We found correlations between H2S and corticosterone, and corticosterone and IL-1β. These data are consistent with the notion that the responses to systemic inflammation are tightly regulated through adjustments in POA H2S production which may play an anti-inflammatory role downmodulating plasma cytokines levels and upregulating corticosterone release.

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Gaseous Mediators in Temperature Regulation

Cited by 33 publications

References 404 publications

Neuroanatomical Relationship of Neuronal Nitric Oxide Synthase to Gonadotropin-Releasing Hormone and Kisspeptin Neurons in Adult Female Sheep and Primates

Neuroanatomical Relationship of Neuronal Nitric Oxide Synthase to Gonadotropin-Releasing Hormone and Kisspeptin Neurons in Adult Female Sheep and Primates

Fever and sickness behavior: Friend or foe?

Effect of Physical Exercise on the Febrigenic Signaling is Modulated by Preoptic Hydrogen Sulfide Production

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