Gasotransmitters

Holwerda, Kim M.; Faas, Marijke M.; Goor, Harry van; Lely, A. Titia

doi:10.1161/hypertensionaha.113.01625

Cited by 19 publications

(11 citation statements)

References 78 publications

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“…Numerous evidences suggest that alterations in the function of the vascular endothelium and a decrease in the availability of endothelial relaxing factors contribute to the pathogenesis and clinical expression of hypertension, among other cardiovascular diseases [9,10,11]. Thus, there is an ongoing search for new pharmacological strategies, whose targets of action activate the signaling pathways of the main vasodilator endothelial factors [12,13], including gasotransmitters, such as nitric oxide (NO) and hydrogen sulfide (H 2 S) [14,15,16,17,18,19,20,21,22,23].…”

Section: Introductionmentioning

confidence: 99%

Role of Nitric Oxide and Hydrogen Sulfide in the Vasodilator Effect of Ursolic Acid and Uvaol from Black Cherry Prunus serotina Fruits

et al. 2016

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Abstract:The present research aimed to isolate the non-polar secondary metabolites that produce the vasodilator effects induced by the dichloromethane extract of Prunus serotina (P. serotina) fruits and to determine whether the NO/cGMP and the H 2 S/K ATP channel pathways are involved in their mechanism of action. A bioactivity-directed fractionation of the dichloromethane extract of P. serotina fruits led to the isolation of ursolic acid and uvaol as the main non-polar vasodilator compounds. These compounds showed significant relaxant effect on rat aortic rings in an endothelium-and concentration-dependent manner, which was inhibited by NG-nitro-L-arginine methyl ester (L-NAME), DL-propargylglycine (PAG) and glibenclamide (Gli). Additionally, both triterpenes increased NO and H 2 S production in aortic tissue. Molecular docking studies showed that ursolic acid and uvaol are able to bind to endothelial NOS and CSE with high affinity for residues that form the oligomeric interface of both enzymes. These results suggest that the vasodilator effect produced by ursolic acid and uvaol contained in P. serotina fruits, involves activation of the NO/cGMP and H 2 S/K ATP channel pathways, possibly through direct activation of NOS and CSE.

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Section: Introductionmentioning

confidence: 99%

Role of Nitric Oxide and Hydrogen Sulfide in the Vasodilator Effect of Ursolic Acid and Uvaol from Black Cherry Prunus serotina Fruits

et al. 2016

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“…Our previous study has shown that H 2 S suppresses contractions in human myometrial strips in vitro [ 22 ], suggesting that H 2 S might be involved in labor process. More recently, it has been implicated that gasotransmitters might be a solution for the therapeutic dilemma for pregnancy diseases such as preeclampsia [ 23 ]. Thus, it would be of interest to explore the effect of H 2 S on PTB.…”

Section: Introductionmentioning

confidence: 99%

Hydrogen Sulfide Delays LPS-Induced Preterm Birth in Mice via Anti-Inflammatory Pathways

Liu

You

et al. 2016

PLoS ONE

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A major cause of preterm labor in pregnant women is intra-amniotic infection, which is mediated by an inflammatory process. Hydrogen sulfide (H2S), a gaseous transmitter, has been implicated to be involved in inflammatory responses. We sought to investigate whether H2S affects infectious preterm birth using the mouse model of lipopolysaccharides (LPS)-induced preterm birth. Administration of LPS at 0.4 mg/kg with two injections intraperitoneally (i.p.) on gestational day 14.5 induced preterm labor. LPS significantly increased leukocyte infiltration in uterus, stimulated the expression of pro-inflammatory cytokines interleukin 1β (IL-1β), IL-6, tumor necrosis factor α (TNF-α), CCL2 and CXCL15 in myometrium. Administration of NaHS (i.p.) delayed the onset of labor induced by LPS in a dose-dependent manner. NaHS prevented leukocyte infiltration into intrauterine tissues and inhibited the production of pro-inflammatory cytokines in myometrium and decreased the levels of these cytokines in maternal circulation. H2S also decreased LPS-activated extracellular signal-regulated kinase (ERK) 1/2/ nuclear factor (NF)-κB signaling pathways in myometrium. This study provides new in vivo evidence for the roles of H2S in attenuating inflammation, and a potential novel therapeutic strategy for infection-related preterm labor.

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“…Preeclampsia is the pregnancy condition in which NO homeostasis has been more intensively studied. Although preeclampsia is characterized by maternal and feto-placental endothelial dysfunction, data on circulating NO in this condition are inconsistent [ 43 ]. The severity of the disease or gestational age at sampling might explain these variations.…”

Section: Resultsmentioning

confidence: 99%

“…The severity of the disease or gestational age at sampling might explain these variations. Nevertheless, concentrations of cyclic GMP are consistently lower in preeclampsia indicating decreased NO bioactivity [ 43 ]. This is in line with increasing maternal plasma ADMA during and before the onset of preeclampsia as compared with healthy pregnancy [ 2 , 43 , 44 ].…”

Section: Resultsmentioning

confidence: 99%

Plasma Levels of Dimethylarginines in Preterm Very Low Birth Weight Neonates: Its Relation with Perinatal Factors and Short-Term Outcome

Moonen

Huizing

Cavallaro

et al. 2014

IJMS

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Endogenously produced inhibitors of nitric oxide (NO) synthase, in particular asymmetric dimethylarginine (ADMA), are currently considered of importance in various disease states characterized by reduced NO availability. We investigated the association between plasma levels of ADMA, symmetric dimethylarginine (SDMA), l-arginine, and citrulline and perinatal factors and outcome in 130 preterm (gestational age ≤30 weeks) very low birth weight (VLBW, <1500 g) infants. Plasma samples were collected 6–12 h after birth. We did not find significant correlations between ADMA, SDMA, l-arginine, and citrulline levels and gestational age or birth weight. However, the arginine:ADMA ratio (AAR, a better indicator of NO availability than either arginine or ADMA separately) was positively correlated with gestational age. ADMA and arginine levels were not significantly different between males and females but males showed a negative correlation between ADMA levels and gestational age. Perinatal factors such as preeclampsia, chrorioamnionitis, prolonged rupture of membranes, or form of delivery did not significantly alter dimethylarginine levels or AAR. In contrast, the AAR was significantly reduced in the infants with respiratory distress, mechanical ventilation, and systemic hypotension Therefore, our data suggest that altered NO availability may play a role in the respiratory and cardiovascular adaptation in preterm VLBW infants.

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Gasotransmitters

Cited by 19 publications

References 78 publications

Role of Nitric Oxide and Hydrogen Sulfide in the Vasodilator Effect of Ursolic Acid and Uvaol from Black Cherry Prunus serotina Fruits

Role of Nitric Oxide and Hydrogen Sulfide in the Vasodilator Effect of Ursolic Acid and Uvaol from Black Cherry Prunus serotina Fruits

Hydrogen Sulfide Delays LPS-Induced Preterm Birth in Mice via Anti-Inflammatory Pathways

Plasma Levels of Dimethylarginines in Preterm Very Low Birth Weight Neonates: Its Relation with Perinatal Factors and Short-Term Outcome

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