Gasotransmitters: novel regulators of ion channels and transporters

Althaus, Mike; Clauss, Wolfgang

doi:10.3389/fphys.2013.00027

Cited by 11 publications

(10 citation statements)

References 20 publications

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“…In nervous systems, three diffusible gases, nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H 2 S), are now generally recognized as serving roles as neurotransmitters/modulators ( e.g. Althaus and Clauss, 2013; Barañano et al, 2001; Barañano and Snyder, 2001; Boehning and Snyder, 2003; Gadalla and Snyder, 2010; Garthwaite, 2008; Mustafa et al, 2009; Snyder and Ferris, 2000; Vandiver and Snyder, 2012). …”

Section: Introductionmentioning

confidence: 99%

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Diffusible gas transmitter signaling in the copepod crustacean Calanus finmarchicus: Identification of the biosynthetic enzymes of nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) using a de novo assembled transcriptome

Christie¹,

Fontanilla²,

Roncalli³

et al. 2014

General and Comparative Endocrinology

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Neurochemical signaling is a major component of physiological/behavioral control throughout the animal kingdom. Gas transmitters are perhaps the most ancient class of molecules used by nervous systems for chemical communication. Three gases are generally recognized as being produced by neurons: nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S). As part of an ongoing effort to identify and characterize the neurochemical signaling systems of the copepod Calanus finmarchicus, the biomass dominant zooplankton in much of the North Atlantic Ocean, we have mined a de novo assembled transcriptome for sequences encoding the neuronal biosynthetic enzymes of these gases, i.e. nitric oxide synthase (NOS), heme oxygenase (HO) and cystathionine β-synthase (CBS), respectively. Using Drosophila proteins as queries, two NOS-, one HO-, and one CBS-encoding transcripts were identified. Reverse BLAST and structural analyses of the deduced proteins suggest that each is a true member of its respective enzyme family. RNA-Seq data collected from embryos, early nauplii, late nauplii, early copepodites, late copepodites and adults revealed the expression of each transcript to be stage specific: one NOS restricted primarily to the embryo and the other was absent in the embryo but expressed in all other stages, no CBS expression in the embryo, but present in all other stages, and HO expressed across all developmental stages. Given the importance of gas transmitters in the regulatory control of a number of physiological processes, these data open opportunities for investigating the roles these proteins play under different life-stage and environmental conditions in this ecologically important species.

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Section: Introductionmentioning

confidence: 99%

“…nitric oxide synthase (NOS) for NO, heme oxygenase (HO) for CO, and cystathionine β-synthase (CBS) for H 2 S ( e.g. Althaus and Clauss, 2013). …”

Section: Introductionmentioning

confidence: 99%

Diffusible gas transmitter signaling in the copepod crustacean Calanus finmarchicus: Identification of the biosynthetic enzymes of nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) using a de novo assembled transcriptome

Christie¹,

Fontanilla²,

Roncalli³

et al. 2014

General and Comparative Endocrinology

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“…Анализ данных литературы указывает на важную роль газотрансмиттеров (CH 4 , CO 2 , C 2 H 6 , CO и NH 3 ) во внутри-и межвидовой микробной коммуникации, а также в диалоге микробиота-хозяин. Известна роль этого взаимодействия на здоровье человека, его влияние на психику человека и социальное поведение, а также возможность создания пробиотических препаратов с нейрохимическим эффектом [8,13,15]…”

Section: о б с у ж д е н и еunclassified

Metabolic Activity of High-Antagonistic Strains of Lactobacilli Isolated From Healthy People

Chervinets

Belyaeva

et al. 2018

Journal of microbiology, epidemiology and immunobiology

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Тверской государственный медицинский университетЦель. Оценить метаболическую активность высокоантагонистических штаммов лактобацилл, выделенных из полости рта и кишечника здоровых людей. Материалы и методы. В исследование включены 9 высокоантагонистически активных штамма лактобацилл, выделенных из зубного налета и кишечника здоровых людей разных возрастных групп от 8 до 35 лет. У лактобацилл были изучены ферменты патогенности, кислотообразование, газовые сигнальные молекулы (CH 4, CO 2, C 2 H 6, CO и NH 3 ), а также степень чувствительности к соляной кислоте, желчи. Результаты. Все исследуемые штаммы лактобацилл были генетически идентифицированы по гену 16S РНК и отнесены к 4 видам: L.fermentum, L.rhamnosus, L.plantarum и L.casei. Они оказались апатогенными, вырабатывали широкий спектр метаболитов разной степени выраженности: молочную кислоту и простые газовые сигнальные молекулы, CH 4, CO 2, C 2 H 6, CO и NH 3 . Кишечные

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“…They are present in various bacterial species (streptomycetes, bacilli, and so on) ( 45 , 47 ), including human/animal pathogenic and symbiotic microorganisms that inhabit the intestines ( 44 ), the oral cavity ( 40 , 48 ), and the vagina ( 49 ). The classical L-arginine-NO pathway coexists with the alternative nitrate-nitrite-NO pathway ( 46 , 50 – 53 ). The alternative pathway is characteristic of intestinal bacteria that obtain nitrate and nitrite from digested food ( 44 ).…”

Section: Gasotransmittersmentioning

confidence: 99%

Neuromodulatory effects and targets of the SCFAs and gasotransmitters produced by the human symbiotic microbiota

Oleskin¹,

Shenderov²

2016

Microbial Ecology in Health & Disease

101

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The symbiotic gut microbiota plays an important role in the development and homeostasis of the host organism. Its physiological, biochemical, behavioral, and communicative effects are mediated by multiple low molecular weight compounds. Recent data on small molecules produced by gut microbiota in mammalian organisms demonstrate the paramount importance of these biologically active molecules in terms of biology and medicine. Many of these molecules are pleiotropic mediators exerting effects on various tissues and organs. This review is focused on the functional roles of gaseous molecules that perform neuromediator and/or endocrine functions. The molecular mechanisms that underlie the effects of microbial fermentation-derived gaseous metabolites are not well understood. It is possible that these metabolites produce their effects via immunological, biochemical, and neuroendocrine mechanisms that involve endogenous and microbial modulators and transmitters; of considerable importance are also changes in epigenetic transcriptional factors, protein post-translational modification, lipid and mitochondrial metabolism, redox signaling, and ion channel/gap junction/transporter regulation. Recent findings have revealed that interactivity among such modulators/transmitters is a prerequisite for the ongoing dialog between microbial cells and host cells, including neurons. Using simple reliable methods for the detection and measurement of short-chain fatty acids (SCFAs) and small gaseous molecules in eukaryotic tissues and prokaryotic cells, selective inhibitors of enzymes that participate in their synthesis, as well as safe chemical and microbial donors of pleiotropic mediators and modulators of host intestinal microbial ecology, should enable us to apply these chemicals as novel therapeutics and medical research tools.

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Gasotransmitters: novel regulators of ion channels and transporters

Cited by 11 publications

References 20 publications

Diffusible gas transmitter signaling in the copepod crustacean Calanus finmarchicus: Identification of the biosynthetic enzymes of nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) using a de novo assembled transcriptome

Diffusible gas transmitter signaling in the copepod crustacean Calanus finmarchicus: Identification of the biosynthetic enzymes of nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) using a de novo assembled transcriptome

Metabolic Activity of High-Antagonistic Strains of Lactobacilli Isolated From Healthy People

Neuromodulatory effects and targets of the SCFAs and gasotransmitters produced by the human symbiotic microbiota

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