Gastric acid secretion and parietal cell mass: Effect of sex hormones

Adeniyi, K.O.

doi:10.1016/0016-5085(91)90460-3

Cited by 52 publications

(29 citation statements)

References 7 publications

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“…In an experiment on gastric acid secretion with regard to sex hormones, ovariectomy significantly increased parietal cell mass as well as basal acid secretion. Conversely, castration of male rats decreased both the number of parietal cells in the gastric mucosa and basal acid secretion [26]. These findings suggest that estrogen may play a role in the pathogenesis of GC.…”

Section: Discussionmentioning

confidence: 58%

Clinical characteristics and outcomes for gastric cancer patients aged 18–30 years

et al. 2014

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Background There is little known about the clinicopathological features and the predictors of survival in extremely young adult patients aged 18-30 years. The aim of this study was to identify clinicopathological features and clinical outcomes for the overall population and for a resectable subgroup of gastric cancer patients aged 18-30 years.Methods From January 2004 to December 2010, 207 patients aged between 18 and 30 years old were diagnosed with gastric cancer and treated at the Asan Medical Center. Clinical findings, histopathological parameters and outcomes were reviewed retrospectively. Patients were further divided into 2 groups according to tumor resectability and then clinicopathological factors that affect tumor resectability and clinical outcomes were analyzed. Results Clinicopathological characteristics of study population showed a predominance of females, undifferentiated tumors, diffuse-type cancers, and advanced gastric cancer. The overall resectability rate was 70.0 % and the median follow-up period was significantly longer in the resectable tumor group (P \ 0.001). Significant prognostic predictors for overall survival in overall patients were higher CEA levels (P = 0.016), larger tumor size (P \ 0.001), unresectability (P = 0.006), and presence of lymphovascular invasion (P = 0.012) in a multivariate analysis. Significant prognostic factors for overall survival in patients with resectable disease included larger tumor size ([4 cm), lymphovascular invasion and higher CEA level in the multivariate analysis. Conclusions Gastric adenocarcinomas in young adult patients aged 18-30 years have unique clinicopathological features. Early detection in a resectable state and subsequent complete resection could increase survival period in young patients with gastric cancer.

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Section: Discussionmentioning

confidence: 58%

Clinical characteristics and outcomes for gastric cancer patients aged 18–30 years

et al. 2014

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“…The fact that the protective effect of HRT is stronger for noncardia tumours, that is, those closer to the bile duct, might support this possibility. Women have a lower gastric acid secretion than men, and oestrogen reduces acid gastric secretion and the mass of parietal cells in rats (Adeniyi, 1991), so oestrogen may affect gastric acid production.…”

Section: Discussionmentioning

confidence: 99%

Hormone replacement therapy and risks of oesophageal and gastric adenocarcinomas

et al. 2005

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Oesophageal and gastric adenocarcinoma share an unexplained male predominance, which would be explained by the hypothesis that oestrogens are protective in this respect. We carried out a nested case -control study of hormone replacement therapy (HRT) among 299 women with oesophageal cancer, 313 with gastric cancer, and 3191 randomly selected control women, frequency matched by age and calendar year in the General Practitioners Research Database in the United Kingdom. Data were adjusted for age, calendar year, tobacco smoking, alcohol consumption, body mass index, hysterectomy, and upper gastrointestinal disorders. Among 1 619 563 person-years of follow-up, more than 50% reduced risk of gastric adenocarcinoma was found among users of HRT compared to nonusers (odds ratio (OR), 0.48, 95% confidence interval (CI) 0.29 -0.79). This inverse association appeared to be stronger for gastric noncardia (OR 0.34, 95% CI 0.14 -0.78) and weaker for gastric cardia tumours (OR 0.68, 95% CI 0.23 -2.01). There was no association between HRT and oesophageal adenocarcinoma (OR 1.17, 95% CI 0.41 -3.32).

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“…Reciprocal changes in gastric acid secretion versus serum estradiol concentrations were reported during the menstrual cycle (Sakaguchi et al 1991). In rats, basal gastric acid output is similar in females and males, whereas histamine-and pentagastrin-stimulated gastric acid output can be decreased by 17 -estradiol administration (Omole 1972, Limlomwongse & Piyachaturawat 1982, Aguwa 1984, Adeniyi 1991, Girma et al 1997.…”

Section: Introductionmentioning

confidence: 99%

Immunolocalization of estrogen receptor alpha and beta in gastric epithelium and enteric neurons

Campbell-Thompson¹,

Reyher²,

Wilkinson³

2001

Journal of Endocrinology

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A sexual dimorphism in gastric acid secretion has been known for many years, with women secreting less acid (40%) than men. The mechanisms mediating this sex difference are unknown, but a role for estrogens is suggested from animal models. Two estrogen receptor (ER) subtypes, ER and ER , mediate genomic effects of estrogens, and mRNA for both subtypes has been detected in the rat stomach. The objective of this study was to determine the cellular distribution of ER and ER proteins in the rat stomach. ER and ER proteins were detected in nuclei of fundic parietal cells and epithelial cells in the progenitor zone. In the antrum, several cells were immunoreactive for ER in regions containing stem and neuroendocrine cell types but ER protein was not detected in antral glands. Both ER and ER proteins were expressed in enteric neurons within the nucleus and cytoplasm, with specific punctate staining for ER in cell bodies and fibers. These studies are the first to show differences between ER and ER proteins in the epithelial cellular distribution in the fundus and antrum and to detect co-expression in enteric neurons. These results suggest that estrogens may inhibit gastric acid secretion via genomic effects in fundic parietal cells through either ER subtype and in antral neuroendocrine cells via ER . Moreover, co-expression of ER and ER in enteric neurons indicates that estrogenic effects could also be mediated through neurogenic reflexes. Our findings imply that direct regulation of multiple cell types by estrogens may contribute to the modulation of gastric functions that have been recognized during the estrous cycle and between the sexes.

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Gastric acid secretion and parietal cell mass: Effect of sex hormones

Cited by 52 publications

References 7 publications

Clinical characteristics and outcomes for gastric cancer patients aged 18–30 years

Clinical characteristics and outcomes for gastric cancer patients aged 18–30 years

Hormone replacement therapy and risks of oesophageal and gastric adenocarcinomas

Immunolocalization of estrogen receptor alpha and beta in gastric epithelium and enteric neurons

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