Gastric acid secretion and parietal cell mass: effects of thyroidectomy and thyroxine

Adeniyi, K.O.; Olowo-Okorun, M. O.

doi:10.1152/ajpgi.1989.256.6.g975

Cited by 10 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The reports that depletion of thyroid hormones inhibits the secretory functions of the digestive tract are fairly concordant [22, 23]. Hypothyroidism affects the entire gastrointestinal system and causes hypomotility [1, 7, 15].…”

Section: Discussionmentioning

confidence: 99%

Does Hypothyroidism Affect Gastrointestinal Motility?

Yaylalı

Kıraç

Yılmaz

et al. 2009

Gastroenterology Research and Practice

View full text Add to dashboard Cite

Background. Gastrointestinal motility and serum thyroid hormone levels are closely related. Our aim was to analyze whether there is a disorder in esophagogastric motor functions as a result of hypothyroidism. Materials and Methods. The study group included 30 females (mean age ± SE 45.17 ± 2.07 years) with primary hypothyroidism and 10 healthy females (mean age ± SE 39.40 ± 3.95 years). All cases underwent esophagogastric endoscopy and scintigraphy. For esophageal scintigraphy, dynamic imaging of esophagus motility protocol, and for gastric emptying scintigraphy, anterior static gastric images were acquired. Results. The mean esophageal transit time (52.56 ± 4.07 sec for patients; 24.30 ± 5.88 sec for controls; P = .02) and gastric emptying time (49.06 ± 4.29 min for the hypothyroid group; 30.4 ± 4.74 min for the control group; P = .01) were markedly increased in cases of hypothyroidism. Conclusion. Hypothyroidism prominently reduces esophageal and gastric motor activity and can cause gastrointestinal dysfunction.

show abstract

Section: Discussionmentioning

confidence: 99%

Does Hypothyroidism Affect Gastrointestinal Motility?

Yaylalı

Kıraç

Yılmaz

et al. 2009

Gastroenterology Research and Practice

View full text Add to dashboard Cite

show abstract

“…Long-term T4 administration increased the mitotic activity of the fundic 'stem' cells of the stomach and basal and secretagogue-stimulated acid secretion via its effect on parietal cell mass (Adeniyi & Olowookorun, 1989). We recently found that prolonged administration of T4 significantly increased the incidence of rat colon tumours induced by azoxymethane (Iishi et al, 1992).…”

mentioning

confidence: 99%

Enhancement by thyroxine of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats

Tatsuta¹,

Baba²,

Yamamoto³

et al. 1993

Br J Cancer

View full text Add to dashboard Cite

25 weeks, the rats received s.c. injections of T4 (0.2 jug kg-') in depot form every other day until the end of the experiment in Week 52. This long-term treatment with T4 significantly increased the incidence of gastric cancers in Week 52. However, it did not influence the histological type of the gastric cancers. It also caused significant increases in the labelling indices of the fundic and antral epithelial cells. These findings indicate that T4 enhances the development of gastric cancers, and that its effect may be related to its effect in increasing proliferation of gastric epithelial cells.Thyroid hormones have important regulatory roles in the morphology and biochemistry of gastrointestinal mucosal cells (Hernandez et al., 1988). Long-term T4 administration increased the mitotic activity of the fundic 'stem' cells of the stomach and basal and secretagogue-stimulated acid secretion via its effect on parietal cell mass (Adeniyi & Olowookorun, 1989). We recently found that prolonged administration of T4 significantly increased the incidence of rat colon tumours induced by azoxymethane (Iishi et al., 1992). These findings suggest that T4 might influence gastric carcinogenesis. Therefore, in the present work, we examined the effect of treatment of rats with T4 on the development of gastric cancers in rats. Materials and methods AnimalsSixty 6-week-old male Wistar rats (SLC, Shizuoka, Japan) were used in this study. (Siegel, 1956). Other results were all analysed by one-way analysis of variance with Dunn's multiple comparison (Snedecor & Cochran, 1967;Miller, 1966

show abstract

“…Akiyama et al (1982) found out that the administration of thyroxine into rats led to significant increases in serum T 3 level, gastric pH (reduced acid secretion) and serum gastrin level. Adeniyi and Olowookorun observed that chronic administration of thyroxine increased parietal cell mass, as well as basal acid secretion and histamine-stimulated acid secretion (Adeniyi and Olowookorun, 1989), mice also show the same trend (Olaleye and Elegbe, 2005).…”

Section: Introductionmentioning

confidence: 82%