Gastric acid secretion in Chinese with particular reference to the dose of histamine required for maximal stimulation

Abstract

SUMMARY Studies of basal and histamine-stimulated gastric acid secretion were performed in 42 controls, in 133 patients with duodenal ulceration, in 57 patients with gastric ulceration, in 13 patients with both duodenal and gastric ulceration, and in 20 patients with gastric carcinoma. All these subjects were Chinese. Statistical analysis of the results showed that all clinical groups differed from the controls in both basal and stimulated secretion. The mean basal acid output of Chinese controls and of patients with duodenal ulcer in most cases did not differ statistically when compared with western series. The basal secretion of Chinese patients with gastric ulceration, however, was statistically higher than in most of the western series. The histamine-stimulated response of Chinese controls and patients with duodenal ulcer was statistically much lower than in all western series with which they were compared. For Chinese patients with gastric ulcer, the stimulated responses were in some instances lower than and in others similar to results obtained in some western series. In contrast to most western reports, the basal and histamine-stimulated secretion in Chinese patients with gastric ulcer was significantly higher than in controls. In the Chinese controls and Chinese patients with peptic ulcers the response after histamine was generally lower than western reports. This was due to the inadequacy of the standard dose of histamine acid phosphate of 0.04 mg/kg body weight in Chinese subjects. A dose of 0-06 mg/kg body weight produced a significantly higher acid output. In the comparatively leaner Chinese subjects, therefore, a dose of histamine acid phosphate of 0.06 mg/kg is required for maximal stimulation of gastric acid secretion. This agrees well with the results of a similar study in Indian subjects.

Dose-Response Relationship of Graded Doses of Intravenous Histamine Infusion on Gastric Acid Secretion in Man

“…This relative insensitivity of the parietal cells to administered histamine presumably explain the reported lower values of acid output in Indians [9] and other Asians [7] as compared to Western subjects with a histamine dose of 40 ¡xg/kg/h subcutaneously. D esai et al [3] suggested that this difference in acid output in Indian and Western subjects was an artifact due to ad ministration of dose of histamine on the basis of body weight, which is smaller in Indians.…”

Evaluation of the Frequency of Gastroesophageal Reflux Disease in Hemodialysis Patients

“…Bununla birlikte nondiyaliz popülasyonda GÖRH'ün Asya ve Afrika'da sık olmadığını düşündüren bilgiler bulunmaktadır [13,14] . Bu durum genetik yapı, diyetsel alışkanlıklar, Helicobacter pylori enfeksiyonu sıklığı ile ilişkilendirilmeye çalışılmıştır [15][16][17] .…”

“…Ça-lışmamızda GÖRH olan ve olmayan hastalar arasında diyabet sıklığı benzer bulunmuştur. Benzer şekilde hemodiyaliz hastalarında yapılan başka çalışmalarda da GÖRH olan ve olmayan hastalarda diyabet sıklığı benzer bulunmuştur [12][13][14][15][16][17][18] .…”

“…Sigara alt özefagus sfinkter basın-cında geçici azalma yaptığından dolayı GÖRH sıklığının daha yüksek olması beklenebilir. Ancak hem bizim çalışma-mızda hem de hemodiyaliz hastalarında yapılan diğer çalış- [12][13][14][15][16][17][18] .…”

“…Çalışmamızda, hemodiyaliz hastalarında yapılan diğer çalış-malara benzer şekilde [12][13][14][15][16][17][18] cins, diyaliz süresi, beden kitle indeksi değeri, nonsteroid antienflamatuar ilaç kullanımı, gastroprotektif ajan kullanımı, medeni durum ile GÖRH sıklığı arasında ilişki saptanmamıştır. Namikoshi ve ark'nın çalışmasında GÖRH sıklığının fosfat bağlayıcı ajan, cinacalcet, katyon değiştirici reçine kullananlarda, daha genç hastalarda ve daha önce gastrik ülser öyküsü olan hastalarda daha sık görüldüğü bildirilmiştir [12] , Kawaguchi ve ark'nın çalışmasında ise bizim çalışmamıza benzer şekilde GÖRH sıklığı ile yaş arasında ilişki bulunmamıştır [18] .…”