Gastric adenocarcinoma associated with adenomyoma of the stomach

Abstract

Summary:We report a case of gastric adenomyoma contiguous with adenocarcinoma of the stomach. Although a similar association is well recognized in the duodenum, we believe this to be the first documented case in the stomach. We review the literature on adenomyomata and discuss the implications of this finding.It would appear that glandular and cystic intramural lesions of the stomach are a heterogeneous group, and while there is a well established association between gastric carcinoma and gastritis cystica profunda, the same does not apply to gastric adenomyoma.

Gastric Adenomyoma: The Unexpected Mimicker

“…In the same year, Thorel noted the morphological similarity of GA and HP. The literature is rather confusing, with many reported cases using terms such as myoepithelial hamar- toma, adenomyosis, adenomyomatous hamartoma or myoglandular hamartoma, and pancreatic heterotopia, reflecting disagreement on the histogenesis of this disease [1,2,11,12] . Nevertheless, GA is widely accepted as developmental in origin [1-3, 5, 7-12] .…”

“…The epithelial component is believed to originate from primordial epithelial buds which can differentiate into pancreatic or duodenal tissue. Smooth muscle component can accompany the embrionic epithelial buds or can originate from proliferative stimulation of mislocated epithelium [7,11,12] . These concepts can explain the presence of duodenal and/ or pancreatic tissues in GA as reported in the literature.…”

“…In spite of the availability of newer diagnostic techniques, including endoultrasonography (EUS), it is still difficult to diagnose GA before operation [9,10] . GA is considered a benign tumor, although a potential risk for malignant transformation exists [3,11] .…”

Case Report: Gastric Adenomyoma: Definitely Benign or Defiantly Premalignant?

“…Another specimenbased review examined 109 specimens with pancreatic heterotopia in the gastrointestinal tract and identified 62% of lesions within the stomach and 38% in the small bowel (11). That 85% of gastric adenomyomas are seen in the antrum, with the remaining 15% in the pylorus, was first stated by Zarling (12) based on the review by Goldberg and Margulis (7) and subsequently serially quoted (10,13,14). Various clinicopathologic aspects of gastrointestinal adenomyomas based on some larger review articles are listed in Table 1.…”

Gastric adenomyoma determined incidentally during sleeve gastrectomy: A case report

“…Introduction Gastric adenomyoma has a reported incidence of 0.6 to 5.6% with the majority being found in the upper gastrointestinal tract within 5 to 6 cm of the pylorus, many within the stomach itself [1]. The tumor is produced from the glandular structures embedded in the smooth muscle bundles some of which are lined by cystically enlarged columnar epithelium [2].…”