Gastric adenocarcinoma revealed by atypical pulmonary lymphangitic carcinomatosis

Belhassine, M; Papakrivopoulou, Eugenia; Venet, Christian; Mestdagh, C; Schroeven, Marc

doi:10.21037/jgo.2018.07.06

Cited by 7 publications

(5 citation statements)

References 30 publications

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“…According to past literature, PLC denotes an end‐stage condition of malignancy characterized by the infiltration of lymphatic vessels by tumor cells. GC with PLC is a rare condition, with only a few cases reported, and the disease characteristics or management have not been extensively investigated 28,29 . In our cohort, we comprehensively depicted the clinicopathological and molecular patterns of GC with PLC.…”

Section: Discussionmentioning

confidence: 99%

“…GC with PLC is a rare condition, with only a few cases reported, and the disease characteristics or management have not been extensively investigated. 28,29 In our cohort, we comprehensively depicted the clinicopathological and molecular patterns of GC with PLC. Compared to GC without PLC, GC with PLC has earlier ages at onset, higher tumor burden, more tumor spreading or dissemination, and worse ECOG PS.…”

Section: Sexmentioning

confidence: 99%

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Pulmonary lymphangitis carcinomatosis: A peculiar presentation clustering in MET‐amplified gastric cancer

Zhang,

Yu,

Xie

et al. 2023

Cancer Medicine

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BackgroundThe clinicopathological features of MET‐amplified gastric cancer (GC) and real‐world data on the efficacy of MET‐targeted therapies remain unknown. Pulmonary lymphangitis carcinomatosis (PLC) is a peculiar manifestation of GC, whose management has not been thoroughly described.MethodsThis study analyzed patients diagnosed with MET‐amplified GC or GC with PLC at any time point of the disease course from 2011 to 2021 in two centers. Clinicopathological features and survival outcomes of MET‐amplified GC were analyzed. The clinical and molecular implications of GC with PLC were discussed.ResultsFifty‐eight patients with MET‐amplified GC and 20 patients with GC accompanied by PLC were finally enrolled for analysis (including 13 overlapped patients). GC with PLC was more common in female patients (p = 0.010), diagnosed at a younger age (p = 0.002), presented with a higher baseline ECOG PS (p = 0.016), and was more likely to develop lung metastasis (p < 0.001), and serous effusion (p = 0.026) than GC without PLC. Patients with primary MET‐amplified GC had a worse prognosis than those with secondary MET‐amplified GC (p = 0.005). The application of anti‐MET therapy was associated with numerically prolonged survival, but the association was not statistically significant (p = 0.07). MET amplification was concentrated in patients with PLC, in which anti‐MET therapies elicited a high response rate.ConclusionsMET‐targeted therapies are efficacious in real‐world populations with MET‐amplified GC. Patients with PLC have distinct clinical and molecular features and might benefit from MET‐targeted therapies.

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Section: Discussionmentioning

confidence: 99%

Section: Sexmentioning

confidence: 99%

Pulmonary lymphangitis carcinomatosis: A peculiar presentation clustering in MET‐amplified gastric cancer

Zhang,

Yu,

Xie

et al. 2023

Cancer Medicine

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“…The condition of our patient with both hepatocellular carcinoma (HCC) and gastric signet-ring cell carcinoma who developed PTTM deteriorated faster than that of patients with gastric carcinoma only. Furthermore, we have reviewed 19 reported cases (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). We present the following article in accordance with the CARE reporting checklist (available at http://dx.doi.org/10.21037/tcr-20-3107).…”

Section: Introductionmentioning

confidence: 99%

Pulmonary tumor thrombotic microangiopathy of patient with both hepatocellular carcinoma and gastric signet-ring cell carcinoma: a case report and review of literature

Shen¹,

Li²,

Jiang³

et al. 2021

Transl Cancer Res TCR

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Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare cancer-related complication characterized by intimal proliferation in the pulmonary small arteries with or without tumor emboli, which can be fatal due to progressive pulmonary hypertension (PH). And PTTM is hard to be confirmed during lifetime; hence, it is vital to pay more attention to high-risk PTTM, which may progress quickly.PTTM patients have an extremely poor prognosis. Here, we have reported a case of a patient with both hepatocellular carcinoma (HCC) and gastric signet-ring cell carcinoma who presented with dyspnea and died rapidly and was diagnosed with suspected PTTM. In addition, we have reviewed some related literature. This patient showed a poorer prognosis, with a survival time of only 3 days after oxygen supplementation (very poor compared to the average level of PTTM patients caused by gastric carcinoma only, which was 18 days according to our summary). Besides, respiratory discomfort is the main symptom of PTTM. Abnormal pulmonary imaging was reported with the appearance of septal thickening, ground-glass opacities, small nodules, pleural effusion, and a tree-in-bud pattern in PTTM patients. No effective therapeutic options have been established for PTTM. PTTM should be considered in patients with cancer who progress to rapid respiratory failure and PH, especially in patients with multiple tumors whose condition is more likely to deteriorate quickly.

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“…3 Pathologically, widespread tumour cell invasion of small pulmonary arteries and arterioles of the lung can be seen which leads to vascular stenosis and thrombosis. 3 The radiological findings on computed tomography (CT) are typically diffuse centrilobular nodular opacities in a tree-in-bud pattern. 4,5 A rapid diagnosis of PTTM is essential because the time from onset of the disease to death is short.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Clinically, it is characterized by dyspnoea and pulmonary hypertension. 3 Pathologically, widespread tumour cell invasion of small pulmonary arteries and arterioles of the lung can be seen which leads to vascular stenosis and thrombosis. 3 The radiological findings on computed tomography (CT) are typically diffuse centrilobular nodular opacities in a tree-in-bud pattern.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary tumour thrombotic microangiopathy presented as gastric signet ring cell carcinoma: A case report

2020

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Pulmonary tumour thrombotic microangiopathy (PTTM) is a rare complication of cancer characterized by widespread tumour cell emboli in small arteries and arterioles of the lung and often accompanied by microthrombi. We report a case of PTTM in a young Chinese woman that presented as gastric signet ring cell carcinoma. Although rare, PTTM should be considered in cancer patients with a rapidly progressing dyspnoea, chest computed tomography (CT) scan suggestive of pulmonary hypertension and diffuse pulmonary interstitial infiltration.

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Gastric adenocarcinoma revealed by atypical pulmonary lymphangitic carcinomatosis

Cited by 7 publications

References 30 publications

Pulmonary lymphangitis carcinomatosis: A peculiar presentation clustering in MET‐amplified gastric cancer

Pulmonary lymphangitis carcinomatosis: A peculiar presentation clustering in MET‐amplified gastric cancer

Pulmonary tumor thrombotic microangiopathy of patient with both hepatocellular carcinoma and gastric signet-ring cell carcinoma: a case report and review of literature

Pulmonary tumour thrombotic microangiopathy presented as gastric signet ring cell carcinoma: A case report

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