Gastric and duodenal obstruction in patients with cholangiocarcinoma in the porta hepatis: increased prevalence after radiation therapy.

Mogavero, G; B, Jones; Cameron, J L; Coleman, JoAnn

doi:10.2214/ajr.159.5.1329453

Cited by 14 publications

(3 citation statements)

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“…Anderson, Pinson, Berlin et al 51 The role for prophylactic gastrojejunostomy in patients with cholangiocarcinoma is unclear. There are no data to support its routine use in patients with hilar cholangiocarcinoma, although one paper did find a higher incidence of obstruction in this population of patients following radiation therapy [97]. Patients with distal cholangiocarcinoma may progress similarly to those with carcinoma of the pancreatic head.…”

Section: Palliative Biliary Drainagementioning

confidence: 93%

Diagnosis and Treatment of Cholangiocarcinoma

et al. 2004

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Cholangiocarcinoma presents a formidable diagnostic and treatment challenge. The majority of patients present with unresectable disease and have a survival of less than 12 months following diagnosis. Progress has been made by the appropriate selection of patients for treatment options including resection, with the routine use of more aggressive resections in order to achieve margin-negative resections. This has resulted in longer survival times for these patients. Neoadjuvant and adjuvant therapies have, for the most part, not improved survival in patients with this tumor, and new strategies are needed to improve this line of therapy. The prognosis for unresectable patients is poor, and palliative measures should be aimed at increasing quality of life first and increasing survival second.

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Section: Palliative Biliary Drainagementioning

confidence: 93%

Diagnosis and Treatment of Cholangiocarcinoma

et al. 2004

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“…The tumour type, disease stage, patient's age, nutritional status, presence of additional systemic disorders and previous abdominal surgery are other factors that have role in fi stula formation 6 . Radiotherapy is used at a dose of 4000-5000 rads for gastric carcinoma and radiation-related complications can develop in the stomach at those levels 7,8 . De Cosse et al have reported a higher incidence of adverse radiation effects in hypertensive patients compared to other co-morbid patients 5 .…”

Section: Discussionmentioning

confidence: 99%

A rare case of gastroduodenal fistula following gastric resection and radiotherapy: First case in the literature

Sulu¹,

Demir²,

Ozbilen³

et al. 2011

Kafkas J Med Sci

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“…In a series of 20 patients treated at the Mallinckrodt Institute of Radiology, one patient died of biliary sepsis and another from biliary sepsis attributed to benign strictures [22]. Mogavero et al [27] reported 7 of 96 patients who required gastrojejunostomy after curative resection or palliative stenting for cholangiocarcinoma involving the hepatic duct bifurcation. This complication was seen only in patients who received radiotherapy (49.6-72.2 Gy).…”

Section: Complicationsmentioning

confidence: 99%

Biliary tree malignancies: The University of Minnesota experience

1997

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Because of its slow‐growing natural history, most patients with extrahepatic biliary tree malignancies present with inoperable disease. For the minority of patients with operable disease, surgical resection remains the treatment of choice and offers the patient the best chance for long‐term local control. The role of chemotherapy and radiotherapy in the management of these patients in the definitive, adjuvant, and palliative setting is expanding, although unsettled. Response rates with chemotherapy have been low and will most likely find a place in a combined multimodality setting. Radiotherapy (external beam, intraoperative, and intraluminal brachytherapy using 192Ir) has played a major role in the treatment of these cancers. The close proximity of bowel, kidney, and liver limits the external beam radiotherapy doses that can be safely delivered. Since most patients require placement of percutaneous transhepatic biliary catheters to relieve jaundice, this route has been utilized to deliver higher doses of radiation to the tumor area with intraluminal 192Ir ribbons. The University of Minnesota has treated 15 patients with extrahepatic bile duct cancers. Most were located at the bifurcation of the common bile duct and were treated with intraluminal brachytherapy alone or with external beam radiotherapy. Our results are comparable to previously reported retrospective data with a median survival of 8 months and three long‐term survivors. J. Surg. Oncol. 1997;65:298–305. © 1997 Wiley‐Liss, Inc.

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Gastric and duodenal obstruction in patients with cholangiocarcinoma in the porta hepatis: increased prevalence after radiation therapy.

Cited by 14 publications

References 0 publications

Diagnosis and Treatment of Cholangiocarcinoma

Diagnosis and Treatment of Cholangiocarcinoma

A rare case of gastroduodenal fistula following gastric resection and radiotherapy: First case in the literature

Biliary tree malignancies: The University of Minnesota experience

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