Gastric and Duodenal Ulcer the Association Between Aspirin Ingestion, Smoking and Family History of Ulcer

Gillies, Margaret; Skyring, A. P.

doi:10.5694/j.1326-5377.1969.tb105725.x

Cited by 81 publications

(11 citation statements)

References 6 publications

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“…The importance of chronic conflict has previously been noted in the genesis of peptic ulcer (Brady, 1958), especially regarding sex-role conflict (Draper and Touraine, 1932). This may explain the increased incidence of marital disharmony found in patients with gastric ulcer (Gillies and Skyring, 1969;Alp and Grant, 1970).…”

Section: Discussionmentioning

confidence: 91%

Personality pattern and emotional stress in the genesis of gastric ulcer

H¹,

Court²,

Grant³

1970

Gut

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Section: Discussionmentioning

confidence: 91%

Personality pattern and emotional stress in the genesis of gastric ulcer

H¹,

Court²,

Grant³

1970

Gut

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“…That duodenal ulceration has a familial tendency has been well recorded in the literature (Doll and Buch, 1950;Doll and Kellock, 1951;Kuenssberg, 1962;Sklaroff, 1963;Vesel' et al, 1968;Gillies and Skyring, 1969;Kubickov'a and Vesely, 1972). Our study shows that the early onset patients have a significantly higher frequency of and stronger family history of ulcer dyspepsia (Table 5).…”

Section: Discussionmentioning

confidence: 78%

Duodenal ulcers: early and late onset.

Lam¹,

Ong²

1976

Gut

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SUMMARY A hospital series of 1042 duodenal ulcer patients was examined to determine the relationship of the age of onset of ulcer dyspepsia with the blood group and with the family history of ulcer dyspepsia. It was found that those patients whose symptoms begin in the first two decades of life (early onset patients) contain a significantly larger proportion of group A, B, and AB subjects and a significantly stronger family history of dyspepsia than those whose symptoms begin from the fourth decade of life onwards (late onset patients), in whom blood group 0 prevails. The group 0 status is shown to be associated with a significant proneness to duodenal ulceration and a significant proneness to bleed, and in the late onset patients a significant proneness to bleed recurrently and severely. Bleeding is the predominent complication in the early onset patients. There is a significantly increased tendency for the late onset ulcers to perforate, to become stenosed, to have severe pain, and to be virulent-that is, to be multiple, post-bulbar, or giant. While these features do not appear to be related to the effect of ageing, the occurrence of associated gastric ulceration and the mortality rate was shown to be related.

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“…In a further study involving a large-scale investigatiol. into employees of three separate organizations, these inpatient findings were confirmed (Gillies & Skyring, 1969). The association between aspirin ingestion and gastric ulcers was striking and suggested a causal relationship.…”

Section: Treatment Ofpeptic Ulcerationmentioning

confidence: 71%