Gastric antisecretory and antiulcer activities of Cyclea peltata (Lam.) Hook. f. &amp; Thoms. in rats

Shine, V.J.; Latha, P. G.; Shyamal, S.; Suja, S. R.; Sini, S.; Pradeep, Seetur R.; Rajasekharan, S.

doi:10.1016/j.jep.2009.04.039

Cited by 28 publications

(20 citation statements)

References 20 publications

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“…It is well known the fundamental role of prostaglandins (PGs), particularly PGE 2 and PGI 2, in modulating the integrity of gastric mucosal layers and a variety of cytoprotective factors [ 52 , 53 ]. PGs plays a significant part in resisting gastric mucosal injury as they control gastric acid secretion, enhances gastric mucus and bicarbonate production [ 54 ], increases mucosal blood flow and prohibits the diffusion of ulcerative agents into the gastric mucosa [ 55 ]. Earlier studies demonstrated the gastroprotective action of PG against ethanol-induced gastric damage [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

“…These results demonstrated the essential role of mucus as a defensive factor in the observed gastroprotection promoted by zerumbone. Taken into account the stimulatory effect of NP-SH [ 62 ] and PGE 2 [ 54 ] on character and gastric mucus synthesis, we hypothesized that those factors may be implicated and elucidated the positive impact of zerumbone on maintaining gastric mucus production.…”

Section: Discussionmentioning

confidence: 99%

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Antisecretory, Gastroprotective, Antioxidant and Anti-Helicobcter Pylori Activity of Zerumbone from Zingiber Zerumbet (L.) Smith

et al. 2015

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Background Zingiber zerumbet Smith is a perennial herb, broadly distributed in many tropical areas. In Malaysia, it’s locally known among the Malay people as “lempoyang” and its rhizomes, particularly, is widely used in traditional medicine for the treatment of peptic ulcer disease beyond other gastric disorders.Aim of the studyThe aim of the current study is to evaluate the gastroprotective effect of zerumbone, the main bioactive compound of Zingiber zerumbet rhizome, against ethanol-induced gastric ulcer model in rats.Materials and MethodsRats were pre-treated with zerumbone and subsequently exposed to acute gastric ulcer induced by absolute ethanol administration. Following treatment, gastric juice acidity, ulcer index, mucus content, histological analysis (HE and PAS), immunohistochemical localization for HSP-70, prostaglandin E2 synthesis (PGE2), non-protein sulfhydryl gastric content (NP-SH), reduced glutathione level (GSH), and malondialdehyde level (MDA) were evaluated in ethanol-induced ulcer in vivo. Ferric reducing antioxidant power assay (FRAP) and anti-H. pylori activity were investigated in vitro.ResultsThe results showed that the intragastric administration of zerumbone protected the gastric mucosa from the aggressive effect of ethanol-induced gastric ulcer, coincided with reduced submucosal edema and leukocyte infiltration. This observed gastroprotective effect of zerumbone was accompanied with a significant (p <0.05) effect of the compound to restore the lowered NP-SH and GSH levels, and to reduce the elevated MDA level into the gastric homogenate. Moreover, the compound induced HSP-70 up-regulation into the gastric tissue. Furthermore, zerumbone significantly (p <0.05) enhanced mucus production, showed intense PAS stain and maintained PG content near to the normal level. The compound exhibited antisecretory activity and an interesting minimum inhibitory concentration (MIC) against H. pylori strain.ConclusionThe results of the present study revealed that zerumbone promotes ulcer protection, which might be attributed to the maintenance of mucus integrity, antioxidant activity, and HSP-70 induction. Zerumbone also exhibited antibacterial action against H. pylori.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antisecretory, Gastroprotective, Antioxidant and Anti-Helicobcter Pylori Activity of Zerumbone from Zingiber Zerumbet (L.) Smith

et al. 2015

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“…It has been established that 70 % methanolic leaf extract of C. peltata can effectively ameliorate the oxidative stress parameters observed in cisplatin-induced renal toxicity and could be used as a natural antioxidant against cisplatin-induced oxidative stress (Vijayan et al 2007a , b ). Similarly, modulatory effect, antisecretory effect, and antiulcer properties of this plant have been reported (Christina et al 2002 ;Shine et al 2009 ).…”

Section: Cyclea Peltata Lamsupporting

confidence: 62%

In Vitro Strategies for the Conservation of Some Medicinal and Horticultural Climbers

Thomas

Hoshino

2015

Biotechnological Strategies for the Conservation of Medicinal and Ornamental Climbers

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There has been an increase in use of traditional medicine during the last decade due to the reason that medicinal plant-derived drugs are more effective against several diseases as compared to antibiotics and other medicines and the former has less side effects on patients. Moreover, medicinal plants are a rich source of antibacterial compounds. The increased use and harvest of medicinal plants coupled with habitat destruction caused a decrease in natural population of most of the medicinal plants. In vitro conservation strategies can not only offer large number of plants in limited time but also it can decrease tension on natural populations. Similarly, several horticultural plants including vegetable crops need improvements and therefore in vitro conservation strategies could be applied for their further progress. The present review is an attempt to provide information on various in vitro conservation strategies adopted in selected medicinal and horticultural climbers. The important medicinal and horticultural climbers such as Benincasa hispida ,

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“…The pH was measured using pH meter. Pepsin activity in gastric content was assayed using hemoglobin as substrate according to the modified method of Anson [22], involving digestion of 2% hemoglobin in 0.02 N HCl (pH 2.0, 37°C, 15 min) followed by alkaline condensation with Folin Ciocalteu's reagent and spectrophotometric measurement at 578 nm [23]. The glandular portion of the stomach was weighed and immersed for 2 h in Alcian Blue solution (Sigma-Aldrich, USA) for the mucus quantification procedure.…”

Section: Determination Of Gastric Juice Parameters and Mucus Adherencmentioning

confidence: 99%

Gastroprotective effect and mechanism of patchouli alcohol against ethanol, indomethacin and stress-induced ulcer in rats

Zheng

Xie

et al. 2014

Chemico-Biological Interactions

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Gastric antisecretory and antiulcer activities of Cyclea peltata (Lam.) Hook. f. & Thoms. in rats

Cited by 28 publications

References 20 publications

Antisecretory, Gastroprotective, Antioxidant and Anti-Helicobcter Pylori Activity of Zerumbone from Zingiber Zerumbet (L.) Smith

Antisecretory, Gastroprotective, Antioxidant and Anti-Helicobcter Pylori Activity of Zerumbone from Zingiber Zerumbet (L.) Smith

In Vitro Strategies for the Conservation of Some Medicinal and Horticultural Climbers

Gastroprotective effect and mechanism of patchouli alcohol against ethanol, indomethacin and stress-induced ulcer in rats

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