Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs

Asad, Mohammed; Shewade, Deepak Gopal; Koumaravelou, Kailasam; Abraham, Benny K.; Vasu, S.; Ramaswamy, S.

doi:10.1016/s0024-3205(01)01376-5

Cited by 27 publications

(25 citation statements)

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“…The ulcer formation in pylorus-ligated rats is influenced by changes in secretion of gastric acid, pepsin, and mucus secretion (Kulkarni, 1999;Shay et al, 1945). The ethanolinduced gastric ulcer model was used to determine the effect on acid-independent gastric cytoprotection, and aspirininduced gastric ulcers provide information for the effect on prostaglandin synthesis (Asad et al, 2001;Kumar et al, 2013). The stress-induced gastric ulcers depend on gastric acid secretion and gastric motility.…”

Section: Discussionmentioning

confidence: 99%

“…The stress-induced gastric ulcers depend on gastric acid secretion and gastric motility. Drugs interfering with gastric secretion and/or motility or those having direct calming effect on the central nervous system reduce stressinduced gastric ulcers (Asad et al, 2001;Parmar & Desai 1993). Boswellia sacra water extract aggravated the acetic acid-induced gastric ulcers compared with vehicle-treated control.…”

Section: Discussionmentioning

confidence: 99%

“…Under light ether anesthesia, the stomach was exposed; glacial acetic acid (0.05 ml) was applied onto the serosal surface using cylindrical mould (6 mm) for 60 s. The acid solution was then removed by rinsing the mold with normal saline to prevent damage to the surrounding tissues. The stomach was placed back carefully and the abdominal wall was closed (Asad et al, 2001). The animals were treated with B. sacra extract at either 2 or 5 ml/kg orally once a day for 10 d after induction of ulcer while the control group received only vehicle.…”

Section: Acetic Acid-induced Chronic Gastric Ulcermentioning

confidence: 99%

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Proulcerogenic effect of water extract ofBoswellia sacraoleo gum resin in rats

Asad

Alhomoud

2015

Pharmaceutical Biology

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Context: The water extract of Boswellia sacra Flueck. (Burseraceae) is used in the treatment of gastric and hepatic disorders in the Arab countries. Objective: The effect of Boswellia sacra water extract on gastric secretion and experimentally induced gastric ulcers in rats was studied. Materials and methods: Acetic acid-induced chronic gastric ulcers, pylorus ligation, aspirininduced, ethanol-induced, and restraint plus cold stress-induced gastric ulcer models were employed. The effect on normal rats was also studied. The water extract of B. sacra was administered orally at doses of 2 and 5 ml/kg once daily ranging from single dose to 30 d treatment depending on the model. The extract was subjected to GC-MS analysis to determine the presence of various phytoconstituents. Results: Boswellia sacra water extract (5 ml/kg, p.o (per os)) aggravated acetic acid-induced chronic ulcers, wherein an increase in ulcer index (p50.01) and ulcer score (p50.05) was observed. In pylorus-ligated rats, the extract increased gastric content volume (p50.01), free acidity (p50.01), total acidity (p50.01), ulcer index (p50.01), and pepsin activity (p50.05). There was no significant effect on the development of ethanol-induced and aspirin-induced ulcers while an increase in the development of stress-induced ulcers was observed (p50.01). The extract did not produce any ulcers when administered to normal rats. The dose of 2 ml/kg was less proulcerogenic compared with 5 ml/kg. The GC-MS analysis revealed the presence of several phytoconstituents that included menthol, 3-cyclohexen-1-ol, and octanoic acid. Conclusion: Boswellia sacra water extract has proulcerogenic activity due to its gastric hypersecretory effect.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Acetic Acid-induced Chronic Gastric Ulcermentioning

confidence: 99%

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Proulcerogenic effect of water extract ofBoswellia sacraoleo gum resin in rats

Asad

Alhomoud

2015

Pharmaceutical Biology

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“…The method reported by us earlier was followed 10 . Rats were fasted for 24 h prior to the induction of ulcer.…”

Section: Acetic Acid-induced Chronic Gastric Ulcermentioning

confidence: 99%

“…The abdominal wall was closed by interrupted sutures. The animals were then divided into six different groups; the first group served as control and received vehicle while group 2 received ranitdine (50 mg/kg, p.o) 10 . The third and fourth group rats were treated with myrrh suspension at doses of 500 mg/kg or 1000 mg/kg body weight.…”

Section: Acetic Acid-induced Chronic Gastric Ulcermentioning

confidence: 99%

Antiulcer Effect of Commiphora molmol Engl. (Burceraceae) Oleo-gum-resin and its Interaction with Ranitidine, as Demonstrated by Histological Studies

AL-Yahya¹

2015

Biosci., Biotech. Res. Asia

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Effect of Quercetin With Oral Hypoglycemics in Streptozotocin‐Induced Diabetes, and Its Effect on Ulcerogenic Activity

Mayasa,

S.,

Nelson

et al. 2024

Macromolecular Symposia

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A diabetic‐induced ulcer is a complication of diabetes in which the formation of an ulcer increases and also causes a delay in ulcer healing. Diabetes adds a bonus to various factors like starvation and stress, imbalanced acid‐pepsin secretions, impaired mucosal resistance, acid‐back diffusion, and neuronal dysfunction. Feeding a high‐fat diet for 15 days after induction of STZ in rats develops diabetes mellitus simultaneously with growth, resulting in an acceleration of ulcers for any of the above reasons. The OGTT investigation included both normal and diabetic rats, and the researchers establish a consistently low dosage of conventional oral hypoglycemic agents for the treatment. Clinical studies in the literature highlight that effectively treating patients with diabetes complications has been demonstrated through glycemic control. Hence, effective palliative hypoglycemic agents are employed. Long‐term usage has revealed that they exert a drastic negative effect. Hence, herbal drug combinations with these standard drugs have proved to be effective in minimizing the side effects. QE, which has hypoglycemic, dyslipidemia, and antioxidant properties, has been effective when administered with Glipizide (5 mg kg−1). The monotherapy of this Glipizide and QE has not shown a beneficial effect in protecting the stomach from ulcers. The combination (G + QE) showed effective control of glucose without any hypoglycemia. QE as a single adjunct with Glipizide has proven promising in preventing and treating diabetic ulcers.

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Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs

Cited by 27 publications

References 0 publications

Proulcerogenic effect of water extract ofBoswellia sacraoleo gum resin in rats

Proulcerogenic effect of water extract ofBoswellia sacraoleo gum resin in rats

Antiulcer Effect of Commiphora molmol Engl. (Burceraceae) Oleo-gum-resin and its Interaction with Ranitidine, as Demonstrated by Histological Studies

Effect of Quercetin With Oral Hypoglycemics in Streptozotocin‐Induced Diabetes, and Its Effect on Ulcerogenic Activity

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